Papillary renal cell carcinoma: Clinicopathological characteristics in 40 patients

Takeo Kosaka, Shuji Mikami, Akira Miyajima, Eiji Kikuchi, Ken Nakagawa, Takashi Ohigashi, Jun Nakashima, Mototsugu Oya

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Two different subtypes of papillary renal cell carcinoma (PRCC) have so far been identified, type-1 with small cells and pale cytoplasm and type-2 with large cells and eosinophilic cytoplasm. It has generally been accepted that type-1 tumors have favorable features in comparison with type-2 tumors, suggesting that these subtypes could be different clinicopathological entities, and, as a result, that the subtypes need to be characterized. Forty cases of PRCCs were reviewed, with special attention to the distinct clinicopathological difference and the response to cytokine therapy. Methods: Thirty-five cases of PRCC diagnosed between January 1997 and August 2007 were reviewed. PRCCs were classified according to the criteria of Delahunt and Eble. Results: Of these 40 patients, 20 and 20 were diagnosed to be type-1 and type-2 PRCCs, respectively. No lymphatic or vascular invasion or distant metastasis were observed in patients with type-1 PRCC. The nuclear grade in all type-1 PRCCs was low grade. The nuclear grade (P ≤ 0.01) and the positive rate of vascular invasion (P ≤ 0.05) was significantly higher in type-2 than in type-1 PRCCs. Distant metastasis was detected preoperatively in three patients with type-2 PRCC. One patient with metastatic type-2 PRCCs demonstrated a response to IL-2 therapy. Conclusion: PRCCs include two distinct morphological types of tumor and type-2 PRCCs tends to have unfavorable features in comparison with type-1 PRCCs. These results support the clinical basis for the need to perform morphological subtyping of PRCCs when clinically evaluating such patients.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalClinical and Experimental Nephrology
Volume12
Issue number3
DOIs
Publication statusPublished - 2008 Jun

Fingerprint

Renal Cell Carcinoma
Blood Vessels
Cytoplasm
Neoplasm Metastasis
Neoplasms
Interleukin-2
Cytokines
Therapeutics

Keywords

  • Histology
  • Immunotherapy
  • Papillary renal cell carcinoma

ASJC Scopus subject areas

  • Nephrology

Cite this

Papillary renal cell carcinoma : Clinicopathological characteristics in 40 patients. / Kosaka, Takeo; Mikami, Shuji; Miyajima, Akira; Kikuchi, Eiji; Nakagawa, Ken; Ohigashi, Takashi; Nakashima, Jun; Oya, Mototsugu.

In: Clinical and Experimental Nephrology, Vol. 12, No. 3, 06.2008, p. 195-199.

Research output: Contribution to journalArticle

Kosaka, Takeo ; Mikami, Shuji ; Miyajima, Akira ; Kikuchi, Eiji ; Nakagawa, Ken ; Ohigashi, Takashi ; Nakashima, Jun ; Oya, Mototsugu. / Papillary renal cell carcinoma : Clinicopathological characteristics in 40 patients. In: Clinical and Experimental Nephrology. 2008 ; Vol. 12, No. 3. pp. 195-199.
@article{1376abc0141346cea5c156368c4837ac,
title = "Papillary renal cell carcinoma: Clinicopathological characteristics in 40 patients",
abstract = "Background: Two different subtypes of papillary renal cell carcinoma (PRCC) have so far been identified, type-1 with small cells and pale cytoplasm and type-2 with large cells and eosinophilic cytoplasm. It has generally been accepted that type-1 tumors have favorable features in comparison with type-2 tumors, suggesting that these subtypes could be different clinicopathological entities, and, as a result, that the subtypes need to be characterized. Forty cases of PRCCs were reviewed, with special attention to the distinct clinicopathological difference and the response to cytokine therapy. Methods: Thirty-five cases of PRCC diagnosed between January 1997 and August 2007 were reviewed. PRCCs were classified according to the criteria of Delahunt and Eble. Results: Of these 40 patients, 20 and 20 were diagnosed to be type-1 and type-2 PRCCs, respectively. No lymphatic or vascular invasion or distant metastasis were observed in patients with type-1 PRCC. The nuclear grade in all type-1 PRCCs was low grade. The nuclear grade (P ≤ 0.01) and the positive rate of vascular invasion (P ≤ 0.05) was significantly higher in type-2 than in type-1 PRCCs. Distant metastasis was detected preoperatively in three patients with type-2 PRCC. One patient with metastatic type-2 PRCCs demonstrated a response to IL-2 therapy. Conclusion: PRCCs include two distinct morphological types of tumor and type-2 PRCCs tends to have unfavorable features in comparison with type-1 PRCCs. These results support the clinical basis for the need to perform morphological subtyping of PRCCs when clinically evaluating such patients.",
keywords = "Histology, Immunotherapy, Papillary renal cell carcinoma",
author = "Takeo Kosaka and Shuji Mikami and Akira Miyajima and Eiji Kikuchi and Ken Nakagawa and Takashi Ohigashi and Jun Nakashima and Mototsugu Oya",
year = "2008",
month = "6",
doi = "10.1007/s10157-008-0041-x",
language = "English",
volume = "12",
pages = "195--199",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Papillary renal cell carcinoma

T2 - Clinicopathological characteristics in 40 patients

AU - Kosaka, Takeo

AU - Mikami, Shuji

AU - Miyajima, Akira

AU - Kikuchi, Eiji

AU - Nakagawa, Ken

AU - Ohigashi, Takashi

AU - Nakashima, Jun

AU - Oya, Mototsugu

PY - 2008/6

Y1 - 2008/6

N2 - Background: Two different subtypes of papillary renal cell carcinoma (PRCC) have so far been identified, type-1 with small cells and pale cytoplasm and type-2 with large cells and eosinophilic cytoplasm. It has generally been accepted that type-1 tumors have favorable features in comparison with type-2 tumors, suggesting that these subtypes could be different clinicopathological entities, and, as a result, that the subtypes need to be characterized. Forty cases of PRCCs were reviewed, with special attention to the distinct clinicopathological difference and the response to cytokine therapy. Methods: Thirty-five cases of PRCC diagnosed between January 1997 and August 2007 were reviewed. PRCCs were classified according to the criteria of Delahunt and Eble. Results: Of these 40 patients, 20 and 20 were diagnosed to be type-1 and type-2 PRCCs, respectively. No lymphatic or vascular invasion or distant metastasis were observed in patients with type-1 PRCC. The nuclear grade in all type-1 PRCCs was low grade. The nuclear grade (P ≤ 0.01) and the positive rate of vascular invasion (P ≤ 0.05) was significantly higher in type-2 than in type-1 PRCCs. Distant metastasis was detected preoperatively in three patients with type-2 PRCC. One patient with metastatic type-2 PRCCs demonstrated a response to IL-2 therapy. Conclusion: PRCCs include two distinct morphological types of tumor and type-2 PRCCs tends to have unfavorable features in comparison with type-1 PRCCs. These results support the clinical basis for the need to perform morphological subtyping of PRCCs when clinically evaluating such patients.

AB - Background: Two different subtypes of papillary renal cell carcinoma (PRCC) have so far been identified, type-1 with small cells and pale cytoplasm and type-2 with large cells and eosinophilic cytoplasm. It has generally been accepted that type-1 tumors have favorable features in comparison with type-2 tumors, suggesting that these subtypes could be different clinicopathological entities, and, as a result, that the subtypes need to be characterized. Forty cases of PRCCs were reviewed, with special attention to the distinct clinicopathological difference and the response to cytokine therapy. Methods: Thirty-five cases of PRCC diagnosed between January 1997 and August 2007 were reviewed. PRCCs were classified according to the criteria of Delahunt and Eble. Results: Of these 40 patients, 20 and 20 were diagnosed to be type-1 and type-2 PRCCs, respectively. No lymphatic or vascular invasion or distant metastasis were observed in patients with type-1 PRCC. The nuclear grade in all type-1 PRCCs was low grade. The nuclear grade (P ≤ 0.01) and the positive rate of vascular invasion (P ≤ 0.05) was significantly higher in type-2 than in type-1 PRCCs. Distant metastasis was detected preoperatively in three patients with type-2 PRCC. One patient with metastatic type-2 PRCCs demonstrated a response to IL-2 therapy. Conclusion: PRCCs include two distinct morphological types of tumor and type-2 PRCCs tends to have unfavorable features in comparison with type-1 PRCCs. These results support the clinical basis for the need to perform morphological subtyping of PRCCs when clinically evaluating such patients.

KW - Histology

KW - Immunotherapy

KW - Papillary renal cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=44149117472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44149117472&partnerID=8YFLogxK

U2 - 10.1007/s10157-008-0041-x

DO - 10.1007/s10157-008-0041-x

M3 - Article

C2 - 18324351

AN - SCOPUS:44149117472

VL - 12

SP - 195

EP - 199

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 3

ER -