Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

Tomihisa Ohta; Takuro Maruyama; Minoru Nagahashi; Yasuyo Miyamoto; Shinzo Hosoi; Fumiyuki Kiuchi; Yasushi Yamazoe; Sachiko Tsukamoto

doi:10.1016/S0040-4020(02)00739-1

Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

Tomihisa Ohta, Takuro Maruyama, Minoru Nagahashi, Yasuyo Miyamoto, Shinzo Hosoi, Fumiyuki Kiuchi, Yasushi Yamazoe, Sachiko Tsukamoto

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

Original language	English
Pages (from-to)	6631-6635
Number of pages	5
Journal	Tetrahedron
Volume	58
Issue number	33
DOIs	https://doi.org/10.1016/S0040-4020(02)00739-1
Publication status	Published - 2002 Aug 12
Externally published	Yes

Keywords

Absolute stereochemistry
CYP3A4 inhibition
Furanocoumarin
Grapefruit juice
Paradisin

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4020(02)00739-1

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title = "Paradisin C: A new CYP3A4 inhibitor from grapefruit juice",

abstract = "A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.",

keywords = "Absolute stereochemistry, CYP3A4 inhibition, Furanocoumarin, Grapefruit juice, Paradisin",

author = "Tomihisa Ohta and Takuro Maruyama and Minoru Nagahashi and Yasuyo Miyamoto and Shinzo Hosoi and Fumiyuki Kiuchi and Yasushi Yamazoe and Sachiko Tsukamoto",

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language = "English",

volume = "58",

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T1 - Paradisin C

T2 - A new CYP3A4 inhibitor from grapefruit juice

AU - Ohta, Tomihisa

AU - Maruyama, Takuro

AU - Nagahashi, Minoru

AU - Miyamoto, Yasuyo

AU - Hosoi, Shinzo

AU - Kiuchi, Fumiyuki

AU - Yamazoe, Yasushi

AU - Tsukamoto, Sachiko

PY - 2002/8/12

Y1 - 2002/8/12

N2 - A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

AB - A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

KW - Absolute stereochemistry

KW - CYP3A4 inhibition

KW - Furanocoumarin

KW - Grapefruit juice

KW - Paradisin

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U2 - 10.1016/S0040-4020(02)00739-1

DO - 10.1016/S0040-4020(02)00739-1

M3 - Article

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SN - 0040-4020

VL - 58

SP - 6631

EP - 6635

JO - Tetrahedron

JF - Tetrahedron

IS - 33

ER -

Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

Abstract

Keywords

ASJC Scopus subject areas

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