Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

Tomihisa Ohta, Takuro Maruyama, Minoru Nagahashi, Yasuyo Miyamoto, Shinzo Hosoi, Fumiyuki Kiuchi, Yasushi Yamazoe, Sachiko Tsukamoto

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

Original languageEnglish
Pages (from-to)6631-6635
Number of pages5
JournalTetrahedron
Volume58
Issue number33
DOIs
Publication statusPublished - 2002 Aug 12
Externally publishedYes

Keywords

  • Absolute stereochemistry
  • CYP3A4 inhibition
  • Furanocoumarin
  • Grapefruit juice
  • Paradisin

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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