Paradisin C: A new CYP3A4 inhibitor from grapefruit juice

Tomihisa Ohta, Takuro Maruyama, Minoru Nagahashi, Yasuyo Miyamoto, Shinzo Hosoi, Fumiyuki Kiuchi, Yasushi Yamazoe, Sachiko Tsukamoto

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.

Original languageEnglish
Pages (from-to)6631-6635
Number of pages5
JournalTetrahedron
Volume58
Issue number33
DOIs
Publication statusPublished - 2002 Aug 12
Externally publishedYes

Fingerprint

Citrus paradisi
Cytochrome P-450 CYP3A
Stereochemistry
Derivatives
Cytochrome P-450 CYP3A Inhibitors
Furocoumarins
epoxybergamottin

Keywords

  • Absolute stereochemistry
  • CYP3A4 inhibition
  • Furanocoumarin
  • Grapefruit juice
  • Paradisin

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Ohta, T., Maruyama, T., Nagahashi, M., Miyamoto, Y., Hosoi, S., Kiuchi, F., ... Tsukamoto, S. (2002). Paradisin C: A new CYP3A4 inhibitor from grapefruit juice. Tetrahedron, 58(33), 6631-6635. https://doi.org/10.1016/S0040-4020(02)00739-1

Paradisin C : A new CYP3A4 inhibitor from grapefruit juice. / Ohta, Tomihisa; Maruyama, Takuro; Nagahashi, Minoru; Miyamoto, Yasuyo; Hosoi, Shinzo; Kiuchi, Fumiyuki; Yamazoe, Yasushi; Tsukamoto, Sachiko.

In: Tetrahedron, Vol. 58, No. 33, 12.08.2002, p. 6631-6635.

Research output: Contribution to journalArticle

Ohta, T, Maruyama, T, Nagahashi, M, Miyamoto, Y, Hosoi, S, Kiuchi, F, Yamazoe, Y & Tsukamoto, S 2002, 'Paradisin C: A new CYP3A4 inhibitor from grapefruit juice', Tetrahedron, vol. 58, no. 33, pp. 6631-6635. https://doi.org/10.1016/S0040-4020(02)00739-1
Ohta T, Maruyama T, Nagahashi M, Miyamoto Y, Hosoi S, Kiuchi F et al. Paradisin C: A new CYP3A4 inhibitor from grapefruit juice. Tetrahedron. 2002 Aug 12;58(33):6631-6635. https://doi.org/10.1016/S0040-4020(02)00739-1
Ohta, Tomihisa ; Maruyama, Takuro ; Nagahashi, Minoru ; Miyamoto, Yasuyo ; Hosoi, Shinzo ; Kiuchi, Fumiyuki ; Yamazoe, Yasushi ; Tsukamoto, Sachiko. / Paradisin C : A new CYP3A4 inhibitor from grapefruit juice. In: Tetrahedron. 2002 ; Vol. 58, No. 33. pp. 6631-6635.
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