Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan

Akio Koizumi, Kouji H. Harada, Bita Eslami, Yoshinori Fujimine, Noriyuki Hachiya, Iwao Hirosawa, Kayoko Inoue, Sumiko Inoue, Shigeki Koda, Yukinori Kusaka, Katsuyuki Murata, Kazuyuki Omae, Norimitsu Saito, Shinichiro Shimbo, Katsunobu Takenaka, Tatsuya Takeshita, Hidemi Todoriki, Yasuhiko Wada, Takao Watanabe, Masayuki Ikeda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective Exposure to polychlorinated biphenyls (PCBs) is considered to have culminated between 1950 and 1970 in Japan, and exposure through diet, the major exposure route, has decreased significantly over the last 10 years. The primary goal of the present study was to investigate the long-term trends and congener profiles of serum and dietary levels of PCBs using historical samples. Methods Using banked samples collected in 1980, 1995, and 2003 surveys, we determined the daily intakes and serum concentrations of 13 PCB congeners (#74, #99, #118, #138, #146, #153, #156, #163, #164, #170, #180, #182, and #187) in women. Results The total daily PCB intake [ng/day, geometric mean (geometric standard deviation)] decreased signifi- cantly from 523 (2.5) in 1980 to 63 (3.2) in 2003.

Original languageEnglish
Pages (from-to)235-246
Number of pages12
JournalEnvironmental Health and Preventive Medicine
Volume14
Issue number4
DOIs
Publication statusPublished - 2009 Jul

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Polychlorinated Biphenyls
Japan
Serum
Diet

Keywords

  • Aging
  • Congener profiles
  • Decrease in metabolism
  • Diet
  • Polychlorinated biphenyl
  • Serum

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan. / Koizumi, Akio; Harada, Kouji H.; Eslami, Bita; Fujimine, Yoshinori; Hachiya, Noriyuki; Hirosawa, Iwao; Inoue, Kayoko; Inoue, Sumiko; Koda, Shigeki; Kusaka, Yukinori; Murata, Katsuyuki; Omae, Kazuyuki; Saito, Norimitsu; Shimbo, Shinichiro; Takenaka, Katsunobu; Takeshita, Tatsuya; Todoriki, Hidemi; Wada, Yasuhiko; Watanabe, Takao; Ikeda, Masayuki.

In: Environmental Health and Preventive Medicine, Vol. 14, No. 4, 07.2009, p. 235-246.

Research output: Contribution to journalArticle

Koizumi, A, Harada, KH, Eslami, B, Fujimine, Y, Hachiya, N, Hirosawa, I, Inoue, K, Inoue, S, Koda, S, Kusaka, Y, Murata, K, Omae, K, Saito, N, Shimbo, S, Takenaka, K, Takeshita, T, Todoriki, H, Wada, Y, Watanabe, T & Ikeda, M 2009, 'Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan', Environmental Health and Preventive Medicine, vol. 14, no. 4, pp. 235-246. https://doi.org/10.1007/s12199-009-0089-6
Koizumi, Akio ; Harada, Kouji H. ; Eslami, Bita ; Fujimine, Yoshinori ; Hachiya, Noriyuki ; Hirosawa, Iwao ; Inoue, Kayoko ; Inoue, Sumiko ; Koda, Shigeki ; Kusaka, Yukinori ; Murata, Katsuyuki ; Omae, Kazuyuki ; Saito, Norimitsu ; Shimbo, Shinichiro ; Takenaka, Katsunobu ; Takeshita, Tatsuya ; Todoriki, Hidemi ; Wada, Yasuhiko ; Watanabe, Takao ; Ikeda, Masayuki. / Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan. In: Environmental Health and Preventive Medicine. 2009 ; Vol. 14, No. 4. pp. 235-246.
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