Objective Exposure to polychlorinated biphenyls (PCBs) is considered to have culminated between 1950 and 1970 in Japan, and exposure through diet, the major exposure route, has decreased significantly over the last 10 years. The primary goal of the present study was to investigate the long-term trends and congener profiles of serum and dietary levels of PCBs using historical samples. Methods Using banked samples collected in 1980, 1995, and 2003 surveys, we determined the daily intakes and serum concentrations of 13 PCB congeners (#74, #99, #118, #138, #146, #153, #156, #163, #164, #170, #180, #182, and #187) in women. Results The total daily PCB intake [ng/day, geometric mean (geometric standard deviation)] decreased signifi- cantly from 523 (2.5) in 1980 to 63 (3.2) in 2003.
- Congener profiles
- Decrease in metabolism
- Polychlorinated biphenyl
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health