Parallel fluctuation of anti-desmoglein 3 and anti-BP180 autoantibody titres in a patient with bullous pemphigoid

H. Takahashi, H. Anzai, Y. Suzuki, A. Tanikawa, M. Amagai, T. Nishikawa

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9 Citations (Scopus)

Abstract

We report a 73-year-old Japanese female who developed IgG autoantibodies against BP180 as well as desmoglein 3 (Dsg3). She showed tense blisters on the extremities without apparent mucosal involvement and a skin biopsy indicated subepidermal blisters with eosinophilic spongiosis. Her clinical and histologic features indicated the diagnosis of bullous pemphigoid while anti-Dsg3 IgG might not show an apparent pathogenic effect. Interestingly, titres of anti-Dsg3 IgG fluctuated in parallel with those of anti-BP180 IgG throughout the course with two flares. Although the exact mechanism for autoantibody production is still unknown, the close link in the production of IgG autoantibodies against two independent skin antigens suggests a shared immunoregulatory mechanism against cutaneous autoantigens.

Original languageEnglish
Pages (from-to)608-611
Number of pages4
JournalClinical and Experimental Dermatology
Volume29
Issue number6
DOIs
Publication statusPublished - 2004 Nov 1

ASJC Scopus subject areas

  • Dermatology

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