Paraneoplastic anti-3-hydroxy-3-methylglutary-coenzyme a reductase antibody-positive immune-mediated necrotizing myopathy in a patient with uterine cancer

Atsushi Mizuma, Maiko Kouchi, Shizuka Netsu, Sachiko Yutani, Ruriko Kitao, Shigeaki Suzuki, Kenya Murata, Eiichiro Nagata, Shunya Takizawa

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4 Citations (Scopus)


We report the case of a 69-year-old woman with proximal limb muscle weakness, who received postoperative chemotherapy for uterine cancer. Her serum creatinine kinase level was high (10,779 mg/dL) and a muscle biopsy from her left biceps revealed various sizes of muscle fibers accompanied by necrotic and regenerating fibers. She was positive for anti-3 hydroxy-3-methylglutary-coenzyme A reductase (anti-HMGCR) antibodies, but negative for anti-signal recognition particle (anti-SRP) antibodies. She was diagnosed with immune-mediated necrotizing myopathy (IMNM) and treated with prednisolone. Our findings indicate that not only drug-induced myopathy but also paraneoplastic myopathy can be involved in the pathogenesis of IMNM.

Original languageEnglish
Pages (from-to)1915-1918
Number of pages4
JournalInternal Medicine
Issue number14
Publication statusPublished - 2017



  • Immune-mediated necrotizing myopathy
  • Paraneoplastic syndrome
  • Steroid therapy
  • Uterine cancer

ASJC Scopus subject areas

  • Internal Medicine

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