Paraneoplastic anti-3-hydroxy-3-methylglutary-coenzyme a reductase antibody-positive immune-mediated necrotizing myopathy in a patient with uterine cancer

Atsushi Mizuma, Maiko Kouchi, Shizuka Netsu, Sachiko Yutani, Ruriko Kitao, Shigeaki Suzuki, Kenya Murata, Eiichiro Nagata, Shunya Takizawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report the case of a 69-year-old woman with proximal limb muscle weakness, who received postoperative chemotherapy for uterine cancer. Her serum creatinine kinase level was high (10,779 mg/dL) and a muscle biopsy from her left biceps revealed various sizes of muscle fibers accompanied by necrotic and regenerating fibers. She was positive for anti-3 hydroxy-3-methylglutary-coenzyme A reductase (anti-HMGCR) antibodies, but negative for anti-signal recognition particle (anti-SRP) antibodies. She was diagnosed with immune-mediated necrotizing myopathy (IMNM) and treated with prednisolone. Our findings indicate that not only drug-induced myopathy but also paraneoplastic myopathy can be involved in the pathogenesis of IMNM.

Original languageEnglish
Pages (from-to)1915-1918
Number of pages4
JournalInternal Medicine
Volume56
Issue number14
DOIs
Publication statusPublished - 2017

Fingerprint

Uterine Neoplasms
Coenzymes
Muscular Diseases
Oxidoreductases
Antibodies
Signal Recognition Particle
Muscles
Muscle Weakness
Coenzyme A
Prednisolone
Anti-Idiotypic Antibodies
Creatinine
Phosphotransferases
Extremities
Biopsy
Drug Therapy
Serum
Pharmaceutical Preparations

Keywords

  • HMGCR
  • Immune-mediated necrotizing myopathy
  • Paraneoplastic syndrome
  • Steroid therapy
  • Uterine cancer

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Paraneoplastic anti-3-hydroxy-3-methylglutary-coenzyme a reductase antibody-positive immune-mediated necrotizing myopathy in a patient with uterine cancer. / Mizuma, Atsushi; Kouchi, Maiko; Netsu, Shizuka; Yutani, Sachiko; Kitao, Ruriko; Suzuki, Shigeaki; Murata, Kenya; Nagata, Eiichiro; Takizawa, Shunya.

In: Internal Medicine, Vol. 56, No. 14, 2017, p. 1915-1918.

Research output: Contribution to journalArticle

Mizuma, Atsushi ; Kouchi, Maiko ; Netsu, Shizuka ; Yutani, Sachiko ; Kitao, Ruriko ; Suzuki, Shigeaki ; Murata, Kenya ; Nagata, Eiichiro ; Takizawa, Shunya. / Paraneoplastic anti-3-hydroxy-3-methylglutary-coenzyme a reductase antibody-positive immune-mediated necrotizing myopathy in a patient with uterine cancer. In: Internal Medicine. 2017 ; Vol. 56, No. 14. pp. 1915-1918.
@article{e0b18c3675054604baedb0bc4e3c3eb0,
title = "Paraneoplastic anti-3-hydroxy-3-methylglutary-coenzyme a reductase antibody-positive immune-mediated necrotizing myopathy in a patient with uterine cancer",
abstract = "We report the case of a 69-year-old woman with proximal limb muscle weakness, who received postoperative chemotherapy for uterine cancer. Her serum creatinine kinase level was high (10,779 mg/dL) and a muscle biopsy from her left biceps revealed various sizes of muscle fibers accompanied by necrotic and regenerating fibers. She was positive for anti-3 hydroxy-3-methylglutary-coenzyme A reductase (anti-HMGCR) antibodies, but negative for anti-signal recognition particle (anti-SRP) antibodies. She was diagnosed with immune-mediated necrotizing myopathy (IMNM) and treated with prednisolone. Our findings indicate that not only drug-induced myopathy but also paraneoplastic myopathy can be involved in the pathogenesis of IMNM.",
keywords = "HMGCR, Immune-mediated necrotizing myopathy, Paraneoplastic syndrome, Steroid therapy, Uterine cancer",
author = "Atsushi Mizuma and Maiko Kouchi and Shizuka Netsu and Sachiko Yutani and Ruriko Kitao and Shigeaki Suzuki and Kenya Murata and Eiichiro Nagata and Shunya Takizawa",
year = "2017",
doi = "10.2169/internalmedicine.56.8134",
language = "English",
volume = "56",
pages = "1915--1918",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "14",

}

TY - JOUR

T1 - Paraneoplastic anti-3-hydroxy-3-methylglutary-coenzyme a reductase antibody-positive immune-mediated necrotizing myopathy in a patient with uterine cancer

AU - Mizuma, Atsushi

AU - Kouchi, Maiko

AU - Netsu, Shizuka

AU - Yutani, Sachiko

AU - Kitao, Ruriko

AU - Suzuki, Shigeaki

AU - Murata, Kenya

AU - Nagata, Eiichiro

AU - Takizawa, Shunya

PY - 2017

Y1 - 2017

N2 - We report the case of a 69-year-old woman with proximal limb muscle weakness, who received postoperative chemotherapy for uterine cancer. Her serum creatinine kinase level was high (10,779 mg/dL) and a muscle biopsy from her left biceps revealed various sizes of muscle fibers accompanied by necrotic and regenerating fibers. She was positive for anti-3 hydroxy-3-methylglutary-coenzyme A reductase (anti-HMGCR) antibodies, but negative for anti-signal recognition particle (anti-SRP) antibodies. She was diagnosed with immune-mediated necrotizing myopathy (IMNM) and treated with prednisolone. Our findings indicate that not only drug-induced myopathy but also paraneoplastic myopathy can be involved in the pathogenesis of IMNM.

AB - We report the case of a 69-year-old woman with proximal limb muscle weakness, who received postoperative chemotherapy for uterine cancer. Her serum creatinine kinase level was high (10,779 mg/dL) and a muscle biopsy from her left biceps revealed various sizes of muscle fibers accompanied by necrotic and regenerating fibers. She was positive for anti-3 hydroxy-3-methylglutary-coenzyme A reductase (anti-HMGCR) antibodies, but negative for anti-signal recognition particle (anti-SRP) antibodies. She was diagnosed with immune-mediated necrotizing myopathy (IMNM) and treated with prednisolone. Our findings indicate that not only drug-induced myopathy but also paraneoplastic myopathy can be involved in the pathogenesis of IMNM.

KW - HMGCR

KW - Immune-mediated necrotizing myopathy

KW - Paraneoplastic syndrome

KW - Steroid therapy

KW - Uterine cancer

UR - http://www.scopus.com/inward/record.url?scp=85024369646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024369646&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.56.8134

DO - 10.2169/internalmedicine.56.8134

M3 - Article

C2 - 28717093

AN - SCOPUS:85024369646

VL - 56

SP - 1915

EP - 1918

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 14

ER -