Paraneoplastic pemphigus: An association with fludarabine?

C. Gooptu, T. J. Littlewood, P. Frith, C. C. Lyon, A. J. Carmichael, S. Oliwiecki, A. Macwhannell, Masayuki Amagai, T. Hashimoto, D. Dean, J. Allen, F. Wojnarowska

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Paraneoplastic pemphigus is a relatively recently described immunobullous disease with characteristic features. We report three cases of paraneoplastic pemphigus in adult men with chronic lymphocytic leukaemia arising within a week of completion of treatment with fludarabine. In all cases, withdrawal of fludarabine and treatment of the blistering was associated with marked cutaneous improvement. Fludarabine, a synthetic nucleoside analogue, which has only been available in Britain since 1994, is known to be associated with autoimmune phenomena and may have been involved in the development of paraneoplastic pemphigus in these cases.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalBritish Journal of Dermatology
Volume144
Issue number6
DOIs
Publication statusPublished - 2001

Fingerprint

Pemphigus
B-Cell Chronic Lymphocytic Leukemia
Nucleosides
Skin
Therapeutics
fludarabine

Keywords

  • Chronic lymphocytic leukaemia
  • Fludarabine
  • Paraneoplastic pemphigus

ASJC Scopus subject areas

  • Dermatology

Cite this

Gooptu, C., Littlewood, T. J., Frith, P., Lyon, C. C., Carmichael, A. J., Oliwiecki, S., ... Wojnarowska, F. (2001). Paraneoplastic pemphigus: An association with fludarabine? British Journal of Dermatology, 144(6), 1255-1261. https://doi.org/10.1046/j.1365-2133.2001.04244.x

Paraneoplastic pemphigus : An association with fludarabine? / Gooptu, C.; Littlewood, T. J.; Frith, P.; Lyon, C. C.; Carmichael, A. J.; Oliwiecki, S.; Macwhannell, A.; Amagai, Masayuki; Hashimoto, T.; Dean, D.; Allen, J.; Wojnarowska, F.

In: British Journal of Dermatology, Vol. 144, No. 6, 2001, p. 1255-1261.

Research output: Contribution to journalArticle

Gooptu, C, Littlewood, TJ, Frith, P, Lyon, CC, Carmichael, AJ, Oliwiecki, S, Macwhannell, A, Amagai, M, Hashimoto, T, Dean, D, Allen, J & Wojnarowska, F 2001, 'Paraneoplastic pemphigus: An association with fludarabine?', British Journal of Dermatology, vol. 144, no. 6, pp. 1255-1261. https://doi.org/10.1046/j.1365-2133.2001.04244.x
Gooptu C, Littlewood TJ, Frith P, Lyon CC, Carmichael AJ, Oliwiecki S et al. Paraneoplastic pemphigus: An association with fludarabine? British Journal of Dermatology. 2001;144(6):1255-1261. https://doi.org/10.1046/j.1365-2133.2001.04244.x
Gooptu, C. ; Littlewood, T. J. ; Frith, P. ; Lyon, C. C. ; Carmichael, A. J. ; Oliwiecki, S. ; Macwhannell, A. ; Amagai, Masayuki ; Hashimoto, T. ; Dean, D. ; Allen, J. ; Wojnarowska, F. / Paraneoplastic pemphigus : An association with fludarabine?. In: British Journal of Dermatology. 2001 ; Vol. 144, No. 6. pp. 1255-1261.
@article{5e0313eab3e04b9d8ad3aff668a1ca73,
title = "Paraneoplastic pemphigus: An association with fludarabine?",
abstract = "Paraneoplastic pemphigus is a relatively recently described immunobullous disease with characteristic features. We report three cases of paraneoplastic pemphigus in adult men with chronic lymphocytic leukaemia arising within a week of completion of treatment with fludarabine. In all cases, withdrawal of fludarabine and treatment of the blistering was associated with marked cutaneous improvement. Fludarabine, a synthetic nucleoside analogue, which has only been available in Britain since 1994, is known to be associated with autoimmune phenomena and may have been involved in the development of paraneoplastic pemphigus in these cases.",
keywords = "Chronic lymphocytic leukaemia, Fludarabine, Paraneoplastic pemphigus",
author = "C. Gooptu and Littlewood, {T. J.} and P. Frith and Lyon, {C. C.} and Carmichael, {A. J.} and S. Oliwiecki and A. Macwhannell and Masayuki Amagai and T. Hashimoto and D. Dean and J. Allen and F. Wojnarowska",
year = "2001",
doi = "10.1046/j.1365-2133.2001.04244.x",
language = "English",
volume = "144",
pages = "1255--1261",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Paraneoplastic pemphigus

T2 - An association with fludarabine?

AU - Gooptu, C.

AU - Littlewood, T. J.

AU - Frith, P.

AU - Lyon, C. C.

AU - Carmichael, A. J.

AU - Oliwiecki, S.

AU - Macwhannell, A.

AU - Amagai, Masayuki

AU - Hashimoto, T.

AU - Dean, D.

AU - Allen, J.

AU - Wojnarowska, F.

PY - 2001

Y1 - 2001

N2 - Paraneoplastic pemphigus is a relatively recently described immunobullous disease with characteristic features. We report three cases of paraneoplastic pemphigus in adult men with chronic lymphocytic leukaemia arising within a week of completion of treatment with fludarabine. In all cases, withdrawal of fludarabine and treatment of the blistering was associated with marked cutaneous improvement. Fludarabine, a synthetic nucleoside analogue, which has only been available in Britain since 1994, is known to be associated with autoimmune phenomena and may have been involved in the development of paraneoplastic pemphigus in these cases.

AB - Paraneoplastic pemphigus is a relatively recently described immunobullous disease with characteristic features. We report three cases of paraneoplastic pemphigus in adult men with chronic lymphocytic leukaemia arising within a week of completion of treatment with fludarabine. In all cases, withdrawal of fludarabine and treatment of the blistering was associated with marked cutaneous improvement. Fludarabine, a synthetic nucleoside analogue, which has only been available in Britain since 1994, is known to be associated with autoimmune phenomena and may have been involved in the development of paraneoplastic pemphigus in these cases.

KW - Chronic lymphocytic leukaemia

KW - Fludarabine

KW - Paraneoplastic pemphigus

UR - http://www.scopus.com/inward/record.url?scp=0035726363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035726363&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2133.2001.04244.x

DO - 10.1046/j.1365-2133.2001.04244.x

M3 - Article

C2 - 11422053

AN - SCOPUS:0035726363

VL - 144

SP - 1255

EP - 1261

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 6

ER -