Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion-induced excessive interleukin-6 production

Masaharu Akiyama, Masayoshi Yamaoka, Yoko Mikami-Terao, Kentaro Yokoi, Takashi Inoue, Tomomasa Hiramatsu, Shuichi Ashizuka, Jyoji Yoshizawa, Hiroaki Katagi, Masahiro Ikegami, Hiroyuki Ida, Atsuko Nakazawa, Hajime Okita, Kenji Matsumoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopathologically positive for IL-6 and Tyr705-phosphorylation of signal transducer and activator of transcription 3. The EWSR1-CREB1 fusion gene detected in the tumor leads to continuous activation of CREB1 and IL-6 production, because the promoter region of IL-6 has a CREB binding site. Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH.

Original languageEnglish
Pages (from-to)554-559
Number of pages6
JournalJournal of Pediatric Hematology/Oncology
Volume37
Issue number7
Publication statusPublished - 2015 Oct 1
Externally publishedYes

Fingerprint

Paraneoplastic Syndromes
Interleukin-6
STAT3 Transcription Factor
Gene Fusion
Chemokines
Genetic Promoter Regions
Carcinogenesis
Binding Sites
Phosphorylation
Angiomatoid Fibrous Histiocytoma
Cytokines
Serum
Neoplasms

Keywords

  • Angiomatoid fibrous histiocytoma
  • EWSR1-CREB1 fusion gene
  • Interleukin-6
  • Paraneoplastic syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Akiyama, M., Yamaoka, M., Mikami-Terao, Y., Yokoi, K., Inoue, T., Hiramatsu, T., ... Matsumoto, K. (2015). Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion-induced excessive interleukin-6 production. Journal of Pediatric Hematology/Oncology, 37(7), 554-559.

Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion-induced excessive interleukin-6 production. / Akiyama, Masaharu; Yamaoka, Masayoshi; Mikami-Terao, Yoko; Yokoi, Kentaro; Inoue, Takashi; Hiramatsu, Tomomasa; Ashizuka, Shuichi; Yoshizawa, Jyoji; Katagi, Hiroaki; Ikegami, Masahiro; Ida, Hiroyuki; Nakazawa, Atsuko; Okita, Hajime; Matsumoto, Kenji.

In: Journal of Pediatric Hematology/Oncology, Vol. 37, No. 7, 01.10.2015, p. 554-559.

Research output: Contribution to journalArticle

Akiyama, M, Yamaoka, M, Mikami-Terao, Y, Yokoi, K, Inoue, T, Hiramatsu, T, Ashizuka, S, Yoshizawa, J, Katagi, H, Ikegami, M, Ida, H, Nakazawa, A, Okita, H & Matsumoto, K 2015, 'Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion-induced excessive interleukin-6 production', Journal of Pediatric Hematology/Oncology, vol. 37, no. 7, pp. 554-559.
Akiyama, Masaharu ; Yamaoka, Masayoshi ; Mikami-Terao, Yoko ; Yokoi, Kentaro ; Inoue, Takashi ; Hiramatsu, Tomomasa ; Ashizuka, Shuichi ; Yoshizawa, Jyoji ; Katagi, Hiroaki ; Ikegami, Masahiro ; Ida, Hiroyuki ; Nakazawa, Atsuko ; Okita, Hajime ; Matsumoto, Kenji. / Paraneoplastic syndrome of angiomatoid fibrous histiocytoma may be caused by EWSR1-CREB1 fusion-induced excessive interleukin-6 production. In: Journal of Pediatric Hematology/Oncology. 2015 ; Vol. 37, No. 7. pp. 554-559.
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AB - We describe a 7-year-old girl with angiomatoid fibrous histiocytoma (AFH) presenting severe inflammatory symptoms. The cytokine/chemokine profile of serum samples before and after surgery demonstrated that interleukin (IL)-6 had decreased by the greatest percentage. The AFH cells were immunopathologically positive for IL-6 and Tyr705-phosphorylation of signal transducer and activator of transcription 3. The EWSR1-CREB1 fusion gene detected in the tumor leads to continuous activation of CREB1 and IL-6 production, because the promoter region of IL-6 has a CREB binding site. Thus, IL-6 plays pivotal roles in both paraneoplastic syndrome and the oncogenesis of AFH.

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