Abstract
Aims: To investigate possible associations between diabetic microangiopathy and genetic polymorphisms in factors relevant to arterial thrombosis. Methods: We conducted a case-control study on a total of 280 patients with Type 2 diabetes, comparing those without retinopathy or nephropathy (n = 92) and those with microangiopathies (n = 188), for the association of polymorphisms in four candidate genes, paraoxonase 1 (PON1), plasminogen activator inhibitor-1, fibrinogen, and platelet glycoprotein Ibα. Results: There were no differences between the two study groups in gender distribution, age at diagnosis of diabetes (47.9 ± 8.4 and 49.0 ± 11.4 years, respectively), or duration of diabetes (14.9 ± 4.5 and 14.5 ± 8.4 years, respectively). Among the gene polymorphisms tested, the 192Gln/Arg polymorphism of PON1 was associated with the prevalence of retinopathy [odds ratio (OR) = 3.13, 95% confidence interval (CI) = 1.42-6.89, P = 0.0046, Gin/Gin vs. Gln/Arg and Arg/Arg]. This polymorphism was also associated with nephropathy (OR = 3.01, 95% CI = 1.30-6.98, P = 0.0103). There were no differences between the three PON1 genotypes (Gln/Gln, Gln/Arg, and Arg/Arg) with regard to the present disease status. Logistic regression analysis for the adjustment of other risk factors revealed that genotypes with PON1 192Arg were an independent predictor of retinopathy. No associations were found between microangiopathies and the other polymorphisms evaluated (plasminogen activator inhibitor-1, fibrinogen, and platelet glycoprotein Ibα). Conclusions: This study suggests that the presence of the 192Arg-allele in the PON1 gene is a genetic risk factor for microangiopathy in Type 2 diabetes mellitus.
| Original language | English |
|---|---|
| Pages (from-to) | 837-844 |
| Number of pages | 8 |
| Journal | Diabetic Medicine |
| Volume | 21 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2004 Aug |
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Keywords
- Genetics
- Microangiopathy
- Paraoxonase 1
- Polymorphism
- Type 2 diabetes
ASJC Scopus subject areas
- Endocrinology
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Paraoxonase 1 192Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus. / Murata, Mitsuru; Maruyama, T.; Suzuki, Y.; Saruta, T.; Ikeda, Y.
In: Diabetic Medicine, Vol. 21, No. 8, 08.2004, p. 837-844.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Paraoxonase 1 192Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus
AU - Murata, Mitsuru
AU - Maruyama, T.
AU - Suzuki, Y.
AU - Saruta, T.
AU - Ikeda, Y.
PY - 2004/8
Y1 - 2004/8
N2 - Aims: To investigate possible associations between diabetic microangiopathy and genetic polymorphisms in factors relevant to arterial thrombosis. Methods: We conducted a case-control study on a total of 280 patients with Type 2 diabetes, comparing those without retinopathy or nephropathy (n = 92) and those with microangiopathies (n = 188), for the association of polymorphisms in four candidate genes, paraoxonase 1 (PON1), plasminogen activator inhibitor-1, fibrinogen, and platelet glycoprotein Ibα. Results: There were no differences between the two study groups in gender distribution, age at diagnosis of diabetes (47.9 ± 8.4 and 49.0 ± 11.4 years, respectively), or duration of diabetes (14.9 ± 4.5 and 14.5 ± 8.4 years, respectively). Among the gene polymorphisms tested, the 192Gln/Arg polymorphism of PON1 was associated with the prevalence of retinopathy [odds ratio (OR) = 3.13, 95% confidence interval (CI) = 1.42-6.89, P = 0.0046, Gin/Gin vs. Gln/Arg and Arg/Arg]. This polymorphism was also associated with nephropathy (OR = 3.01, 95% CI = 1.30-6.98, P = 0.0103). There were no differences between the three PON1 genotypes (Gln/Gln, Gln/Arg, and Arg/Arg) with regard to the present disease status. Logistic regression analysis for the adjustment of other risk factors revealed that genotypes with PON1 192Arg were an independent predictor of retinopathy. No associations were found between microangiopathies and the other polymorphisms evaluated (plasminogen activator inhibitor-1, fibrinogen, and platelet glycoprotein Ibα). Conclusions: This study suggests that the presence of the 192Arg-allele in the PON1 gene is a genetic risk factor for microangiopathy in Type 2 diabetes mellitus.
AB - Aims: To investigate possible associations between diabetic microangiopathy and genetic polymorphisms in factors relevant to arterial thrombosis. Methods: We conducted a case-control study on a total of 280 patients with Type 2 diabetes, comparing those without retinopathy or nephropathy (n = 92) and those with microangiopathies (n = 188), for the association of polymorphisms in four candidate genes, paraoxonase 1 (PON1), plasminogen activator inhibitor-1, fibrinogen, and platelet glycoprotein Ibα. Results: There were no differences between the two study groups in gender distribution, age at diagnosis of diabetes (47.9 ± 8.4 and 49.0 ± 11.4 years, respectively), or duration of diabetes (14.9 ± 4.5 and 14.5 ± 8.4 years, respectively). Among the gene polymorphisms tested, the 192Gln/Arg polymorphism of PON1 was associated with the prevalence of retinopathy [odds ratio (OR) = 3.13, 95% confidence interval (CI) = 1.42-6.89, P = 0.0046, Gin/Gin vs. Gln/Arg and Arg/Arg]. This polymorphism was also associated with nephropathy (OR = 3.01, 95% CI = 1.30-6.98, P = 0.0103). There were no differences between the three PON1 genotypes (Gln/Gln, Gln/Arg, and Arg/Arg) with regard to the present disease status. Logistic regression analysis for the adjustment of other risk factors revealed that genotypes with PON1 192Arg were an independent predictor of retinopathy. No associations were found between microangiopathies and the other polymorphisms evaluated (plasminogen activator inhibitor-1, fibrinogen, and platelet glycoprotein Ibα). Conclusions: This study suggests that the presence of the 192Arg-allele in the PON1 gene is a genetic risk factor for microangiopathy in Type 2 diabetes mellitus.
KW - Genetics
KW - Microangiopathy
KW - Paraoxonase 1
KW - Polymorphism
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=3843121108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3843121108&partnerID=8YFLogxK
U2 - 10.1111/j.1464-5491.2004.01252.x
DO - 10.1111/j.1464-5491.2004.01252.x
M3 - Article
C2 - 15270786
AN - SCOPUS:3843121108
VL - 21
SP - 837
EP - 844
JO - Diabetic medicine : a journal of the British Diabetic Association
JF - Diabetic medicine : a journal of the British Diabetic Association
SN - 0742-3071
IS - 8
ER -