@article{5334f34b40414d56911b9dac2b604899,
title = "Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation",
abstract = "The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.",
keywords = "Inflammation, L-glutamate, Paroxetine",
author = "Koki Fujimori and Junpei Takaki and Yukari Shigemoto-Mogami and Yuko Sekino and Takeshi Suzuki and Kaoru Sato",
note = "Funding Information: This work was partly supported by a Grant-in-Aid for Young Scientists from Ministry of Education, Culture, Sports, Science, and Technology , Japan ( KAKENHI 21700422 ), the Program for Promotion of Fundamental Studies in Health Sciences of National Institute of Biomedical Innovaton (10-21), Japan, a Health and Labor Science Research Grant for Research on Risks of Chemicals, a Labor Science Research Grant for Research on New Drug Development from the MHLW, Japan, awarded to K.S., Grant-in-Aid for research from MEXT, Japan ( KAKENHI C23590113 ) awarded to T.S., and a Health and Labor Science Research Grant for Research on Publicly Essential Drugs and Medical Devices, Japan, awarded to Y.S. Publisher Copyright: {\textcopyright} 2014 Japanese Pharmacological Society.",
year = "2015",
month = jan,
doi = "10.1016/j.jphs.2014.09.002",
language = "English",
volume = "127",
pages = "145--149",
journal = "Journal of Pharmacological Sciences",
issn = "1347-8613",
publisher = "Japanese Pharmacological Society",
number = "1",
}