Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

Koki Fujimori, Junpei Takaki, Yukari Shigemoto-Mogami, Yuko Sekino, Takeshi Suzuki, Kaoru Sato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalJournal of Pharmacological Sciences
Volume127
Issue number1
DOIs
Publication statusPublished - 2015 Jan

Keywords

  • Inflammation
  • L-glutamate
  • Paroxetine

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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