Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

Koki Fujimori; Junpei Takaki; Yukari Shigemoto-Mogami; Yuko Sekino; Takeshi Suzuki; Kaoru Sato

doi:10.1016/j.jphs.2014.09.002

Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

Koki Fujimori, Junpei Takaki, Yukari Shigemoto-Mogami, Yuko Sekino, Takeshi Suzuki, Kaoru Sato

School of Pharmacy

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

Original language	English
Pages (from-to)	145-149
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	127
Issue number	1
DOIs	https://doi.org/10.1016/j.jphs.2014.09.002
Publication status	Published - 2015 Jan

Keywords

Inflammation
L-glutamate
Paroxetine

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

Access to Document

10.1016/j.jphs.2014.09.002

Fingerprint Dive into the research topics of 'Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation'. Together they form a unique fingerprint.

Cite this

Fujimori, K., Takaki, J., Shigemoto-Mogami, Y., Sekino, Y., Suzuki, T., & Sato, K. (2015). Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation. Journal of Pharmacological Sciences, 127(1), 145-149. https://doi.org/10.1016/j.jphs.2014.09.002

@article{5334f34b40414d56911b9dac2b604899,

title = "Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation",

abstract = "The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.",

keywords = "Inflammation, L-glutamate, Paroxetine",

author = "Koki Fujimori and Junpei Takaki and Yukari Shigemoto-Mogami and Yuko Sekino and Takeshi Suzuki and Kaoru Sato",

year = "2015",

month = jan,

doi = "10.1016/j.jphs.2014.09.002",

language = "English",

volume = "127",

pages = "145--149",

journal = "Journal of Pharmacological Sciences",

issn = "1347-8613",

publisher = "Japanese Pharmacological Society",

number = "1",

}

TY - JOUR

T1 - Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

AU - Fujimori, Koki

AU - Takaki, Junpei

AU - Shigemoto-Mogami, Yukari

AU - Sekino, Yuko

AU - Suzuki, Takeshi

AU - Sato, Kaoru

PY - 2015/1

Y1 - 2015/1

N2 - The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

AB - The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

KW - Inflammation

KW - L-glutamate

KW - Paroxetine

UR - http://www.scopus.com/inward/record.url?scp=84924044793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924044793&partnerID=8YFLogxK

U2 - 10.1016/j.jphs.2014.09.002

DO - 10.1016/j.jphs.2014.09.002

M3 - Article

C2 - 25704030

AN - SCOPUS:84924044793

VL - 127

SP - 145

EP - 149

JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8613

IS - 1

ER -