Abstract
The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.
| Original language | English |
|---|---|
| Pages (from-to) | 145-149 |
| Number of pages | 5 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 127 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 |
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Keywords
- Inflammation
- L-glutamate
- Paroxetine
ASJC Scopus subject areas
- Pharmacology
- Molecular Medicine
Cite this
Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation. / Fujimori, Koki; Takaki, Junpei; Shigemoto-Mogami, Yukari; Sekino, Yuko; Suzuki, Takeshi; Sato, Kaoru.
In: Journal of Pharmacological Sciences, Vol. 127, No. 1, 2015, p. 145-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation
AU - Fujimori, Koki
AU - Takaki, Junpei
AU - Shigemoto-Mogami, Yukari
AU - Sekino, Yuko
AU - Suzuki, Takeshi
AU - Sato, Kaoru
PY - 2015
Y1 - 2015
N2 - The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.
AB - The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.
KW - Inflammation
KW - L-glutamate
KW - Paroxetine
UR - http://www.scopus.com/inward/record.url?scp=84924044793&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924044793&partnerID=8YFLogxK
U2 - 10.1016/j.jphs.2014.09.002
DO - 10.1016/j.jphs.2014.09.002
M3 - Article
C2 - 25704030
AN - SCOPUS:84924044793
VL - 127
SP - 145
EP - 149
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 1
ER -