Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

Koki Fujimori, Junpei Takaki, Yukari Shigemoto-Mogami, Yuko Sekino, Takeshi Suzuki, Kaoru Sato

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

Original languageEnglish
Pages (from-to)145-149
Number of pages5
JournalJournal of Pharmacological Sciences
Volume127
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Amino Acid Transport System X-AG
Paroxetine
Glutamic Acid
Down-Regulation
Astrocytes
Antidepressive Agents
Microglia
Anti-Inflammatory Agents

Keywords

  • Inflammation
  • L-glutamate
  • Paroxetine

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation. / Fujimori, Koki; Takaki, Junpei; Shigemoto-Mogami, Yukari; Sekino, Yuko; Suzuki, Takeshi; Sato, Kaoru.

In: Journal of Pharmacological Sciences, Vol. 127, No. 1, 2015, p. 145-149.

Research output: Contribution to journalArticle

Fujimori, Koki ; Takaki, Junpei ; Shigemoto-Mogami, Yukari ; Sekino, Yuko ; Suzuki, Takeshi ; Sato, Kaoru. / Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation. In: Journal of Pharmacological Sciences. 2015 ; Vol. 127, No. 1. pp. 145-149.
@article{5334f34b40414d56911b9dac2b604899,
title = "Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation",
abstract = "The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.",
keywords = "Inflammation, L-glutamate, Paroxetine",
author = "Koki Fujimori and Junpei Takaki and Yukari Shigemoto-Mogami and Yuko Sekino and Takeshi Suzuki and Kaoru Sato",
year = "2015",
doi = "10.1016/j.jphs.2014.09.002",
language = "English",
volume = "127",
pages = "145--149",
journal = "Journal of Pharmacological Sciences",
issn = "1347-8613",
publisher = "Japanese Pharmacological Society",
number = "1",

}

TY - JOUR

T1 - Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

AU - Fujimori, Koki

AU - Takaki, Junpei

AU - Shigemoto-Mogami, Yukari

AU - Sekino, Yuko

AU - Suzuki, Takeshi

AU - Sato, Kaoru

PY - 2015

Y1 - 2015

N2 - The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

AB - The extracellular L-glutamate (L-Glu) concentration is elevated in neuroinflammation, thereby causing excitotoxicity. One of the mechanisms is down-regulation of astrocyte L-Glu transporters. Some antidepressants have anti-inflammatory effects. We therefore investigated effects of various antidepressants on the down-regulation of astrocyte L-Glu transporters in the in vitro neuroinflammation model. Among these antidepressants, only paroxetine was effective. We previously demonstrated that the down-regulation of astrocyte L-Glu transporters was caused by L-Glu released from activated microglia. We here clarified that only paroxetine inhibited L-Glu release from microglia. This is the novel action of paroxetine, which may bring advantages on the therapy of neuroinflammation.

KW - Inflammation

KW - L-glutamate

KW - Paroxetine

UR - http://www.scopus.com/inward/record.url?scp=84924044793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924044793&partnerID=8YFLogxK

U2 - 10.1016/j.jphs.2014.09.002

DO - 10.1016/j.jphs.2014.09.002

M3 - Article

C2 - 25704030

AN - SCOPUS:84924044793

VL - 127

SP - 145

EP - 149

JO - Journal of Pharmacological Sciences

JF - Journal of Pharmacological Sciences

SN - 1347-8613

IS - 1

ER -