Partition coefficients of polyphenols for phosphatidylcholine investigated by HPLC with an immobilized artificial membrane column

Yoshinori Uekusa, Yuko Takeshita, Takeshi Ishii, Tsutomu Nakayama

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The biological activity of polyphenols in vitro reflects their affinity for cell membranes and the amount of cellular incorporation. The interaction of polyphenols with phosphatidylcholine was investigated by HPLC with an immobilized artificial membrane (IAM) column. The IAM partition coefficients (KIAM) of the polyphenols, calculated by retention times, correlated well with the amounts of polyphenols incorporation into the liposomes.

Original languageEnglish
Pages (from-to)3289-3292
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number12
Publication statusPublished - 2008 Dec 1



  • HPLC
  • IAM partition coefficient (K)
  • Immobilized artificial membrane (IAM)
  • Lipid membranes
  • Polyphenol

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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