Past obesity as well as present body weight status is a risk factor for diabetic nephropathy

Shu Meguro, Yusuke Kabeya, Karin Tanaka, Toshihide Kawai, Masuomi Tomita, Takeshi Katsuki, Yoichi Oikawa, Yoshihito Atsumi, Akira Shimada, Masami Tanaka, Junichiro Irie, Yoshifumi Saisho, Hiroshi Itoh

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Abstract

Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined "current obesity" as BMI on hospitalization of 25 or more, "previous obesity" as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and "continuously lean" as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P<0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy.

Original languageEnglish
Article number590569
JournalInternational Journal of Endocrinology
Volume2013
DOIs
Publication statusPublished - 2013

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Diabetic Nephropathies
Obesity
Body Weight
Type 2 Diabetes Mellitus
Hospitalization
Diabetic Retinopathy
Diabetes Complications
Dyslipidemias
Logistic Models
Regression Analysis
Hypertension

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Past obesity as well as present body weight status is a risk factor for diabetic nephropathy. / Meguro, Shu; Kabeya, Yusuke; Tanaka, Karin; Kawai, Toshihide; Tomita, Masuomi; Katsuki, Takeshi; Oikawa, Yoichi; Atsumi, Yoshihito; Shimada, Akira; Tanaka, Masami; Irie, Junichiro; Saisho, Yoshifumi; Itoh, Hiroshi.

In: International Journal of Endocrinology, Vol. 2013, 590569, 2013.

Research output: Contribution to journalArticle

Meguro, Shu ; Kabeya, Yusuke ; Tanaka, Karin ; Kawai, Toshihide ; Tomita, Masuomi ; Katsuki, Takeshi ; Oikawa, Yoichi ; Atsumi, Yoshihito ; Shimada, Akira ; Tanaka, Masami ; Irie, Junichiro ; Saisho, Yoshifumi ; Itoh, Hiroshi. / Past obesity as well as present body weight status is a risk factor for diabetic nephropathy. In: International Journal of Endocrinology. 2013 ; Vol. 2013.
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AU - Meguro, Shu

AU - Kabeya, Yusuke

AU - Tanaka, Karin

AU - Kawai, Toshihide

AU - Tomita, Masuomi

AU - Katsuki, Takeshi

AU - Oikawa, Yoichi

AU - Atsumi, Yoshihito

AU - Shimada, Akira

AU - Tanaka, Masami

AU - Irie, Junichiro

AU - Saisho, Yoshifumi

AU - Itoh, Hiroshi

PY - 2013

Y1 - 2013

N2 - Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined "current obesity" as BMI on hospitalization of 25 or more, "previous obesity" as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and "continuously lean" as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P<0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy.

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