TY - JOUR
T1 - Past obesity as well as present body weight status is a risk factor for diabetic nephropathy
AU - Meguro, Shu
AU - Kabeya, Yusuke
AU - Tanaka, Karin
AU - Kawai, Toshihide
AU - Tomita, Masuomi
AU - Katsuki, Takeshi
AU - Oikawa, Yoichi
AU - Atsumi, Yoshihito
AU - Shimada, Akira
AU - Tanaka, Masami
AU - Irie, Junichiro
AU - Saisho, Yoshifumi
AU - Itoh, Hiroshi
PY - 2013
Y1 - 2013
N2 - Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined "current obesity" as BMI on hospitalization of 25 or more, "previous obesity" as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and "continuously lean" as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P<0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy.
AB - Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined "current obesity" as BMI on hospitalization of 25 or more, "previous obesity" as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and "continuously lean" as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P<0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy.
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U2 - 10.1155/2013/590569
DO - 10.1155/2013/590569
M3 - Article
C2 - 24065991
AN - SCOPUS:84884231253
SN - 1687-8337
VL - 2013
JO - International Journal of Endocrinology
JF - International Journal of Endocrinology
M1 - 590569
ER -
