Past rifampicin dosing determines rifabutin resistance of helicobacter pylori

Shoji Suzuki, Hidekazu Suzuki, Toshihiro Nishizawa, Fumihiko Kaneko, Sumire Ootani, Hiroe Muraoka, Yoshimasa Saito, Intetsu Kobayashi, Toshifumi Hibi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Recently, the number of Helicobacter pylori isolates showing antibiotic resistance has been increasing. Rifabutin (RFB) is one of the possible candidates for H. pylori eradication. In the present study, the RFB minimum inhibitory concentrations (MICs) and the resistance-determining genes to RFB (rpoB) were examined to clarify the relationship between drug MICs, rpoB mutations, and past history of rifampicin (RFP) treatment. Methods: The MICs of RFB and rpoB mutations were examined for 48 strains with failure of H. pylori eradication in the University Hospital and 46 isolated from patients at a specialized hospital for chronic respiratory diseases without past H. pylori eradication. Past RFP treatment was also examined. Results: Eight of 94 strains showed high RFB MICs and 6 of the 8 strains showed rpoB point mutations. Although no strains showed high RFB MICs among 48 strains from the patients in the University Hospital, all 7 strains isolated from patients with past RFP treatment showed high RFB MICs (≥0.12 mg/l). Conclusion: Although RFB might be a potential candidate component of a new H. pylori eradication regimen following the first- or second-line failure, it should be used after examining a past history of RFP treatment.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalDigestion
Volume79
Issue number1
DOIs
Publication statusPublished - 2009 Mar 1

Keywords

  • Cross-resistance
  • Helicobacter pylori
  • Resistance
  • Rifabutin
  • Rifampicin

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Past rifampicin dosing determines rifabutin resistance of helicobacter pylori'. Together they form a unique fingerprint.

  • Cite this

    Suzuki, S., Suzuki, H., Nishizawa, T., Kaneko, F., Ootani, S., Muraoka, H., Saito, Y., Kobayashi, I., & Hibi, T. (2009). Past rifampicin dosing determines rifabutin resistance of helicobacter pylori. Digestion, 79(1), 1-4. https://doi.org/10.1159/000191204