Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis

Koichiro Sakaguchi, Shunsuke Furukawa, Takushige Katsura, Kyoko Yamazaki, Hideo Kawaguchi, Atsushi Maki, Eiji Okada

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The concentration changes in oxygenated haemoglobin and deoxygenated haemoglobin in the brain cortex of guinea pigs associated with brain activation are measured from the multi-spectral images of the cortical tissue. The cortical tissue is observed through a thinned skull. The wavelength dependence of the optical path length is considered in the calculation of haemoglobin concentration. The results are compared with those obtained from the multi-spectral images of the exposed cortex to evaluate the influence of the thinned skull on the measurement of the concentration changes by multi-spectral imaging system. Although the skull thickness affected the sensitivity of the change in reflectance due to decrease in optical path in the cortical tissue, the influence of skull on the wavelength dependence of the optical path length can be ignored when the skull thickness is approximately less than 100 μm.

    Original languageEnglish
    Title of host publicationDiffuse Optical Imaging of Tissue
    Publication statusPublished - 2007 Nov 26
    EventDiffuse Optical Imaging of Tissue - Munich, Germany
    Duration: 2007 Jun 192007 Jun 21

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume6629
    ISSN (Print)1605-7422

    Other

    OtherDiffuse Optical Imaging of Tissue
    CountryGermany
    CityMunich
    Period07/6/1907/6/21

    Keywords

    • Cranial window
    • Multi-spectral imaging
    • Optical path length
    • Thinned skull

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

    Fingerprint Dive into the research topics of 'Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis'. Together they form a unique fingerprint.

    Cite this