Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis

Koichiro Sakaguchi, Shunsuke Furukawa, Takushige Katsura, Kyoko Yamazaki, Hideo Kawaguchi, Atsushi Maki, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The concentration changes in oxygenated haemoglobin and deoxygenated haemoglobin in the brain cortex of guinea pigs associated with brain activation are measured from the multi-spectral images of the cortical tissue. The cortical tissue is observed through a thinned skull. The wavelength dependence of the optical path length is considered in the calculation of haemoglobin concentration. The results are compared with those obtained from the multi-spectral images of the exposed cortex to evaluate the influence of the thinned skull on the measurement of the concentration changes by multispectral imaging system. Although the skull thickness affected the sensitivity of the change in reflectance due to decrease in optical path in the cortical tissue, the influence of skull on the wavelength dependence of the optical path length can be ignored when the skull thickness is approximately less than 100 μm.

Original languageEnglish
Title of host publicationOptics InfoBase Conference Papers
PublisherOptical Society of America
ISBN (Print)9780819467713
Publication statusPublished - 2007
EventEuropean Conference on Biomedical Optics, ECBO 2007 - Munich, Germany
Duration: 2007 Jun 172007 Jun 17

Other

OtherEuropean Conference on Biomedical Optics, ECBO 2007
CountryGermany
CityMunich
Period07/6/1707/6/17

Fingerprint

skull
Hemoglobin
hemoglobin
Tissue
Imaging techniques
optical paths
Brain
cortexes
Wavelength
brain
Imaging systems
guinea pigs
Chemical activation
wavelengths
activation
reflectance
sensitivity

Keywords

  • Cranial window
  • Multi-spectral imaging
  • Optical path length
  • Thinned skull

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

Cite this

Sakaguchi, K., Furukawa, S., Katsura, T., Yamazaki, K., Kawaguchi, H., Maki, A., & Okada, E. (2007). Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis. In Optics InfoBase Conference Papers Optical Society of America.

Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis. / Sakaguchi, Koichiro; Furukawa, Shunsuke; Katsura, Takushige; Yamazaki, Kyoko; Kawaguchi, Hideo; Maki, Atsushi; Okada, Eiji.

Optics InfoBase Conference Papers. Optical Society of America, 2007.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sakaguchi, K, Furukawa, S, Katsura, T, Yamazaki, K, Kawaguchi, H, Maki, A & Okada, E 2007, Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis. in Optics InfoBase Conference Papers. Optical Society of America, European Conference on Biomedical Optics, ECBO 2007, Munich, Germany, 07/6/17.
Sakaguchi K, Furukawa S, Katsura T, Yamazaki K, Kawaguchi H, Maki A et al. Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis. In Optics InfoBase Conference Papers. Optical Society of America. 2007
Sakaguchi, Koichiro ; Furukawa, Shunsuke ; Katsura, Takushige ; Yamazaki, Kyoko ; Kawaguchi, Hideo ; Maki, Atsushi ; Okada, Eiji. / Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis. Optics InfoBase Conference Papers. Optical Society of America, 2007.
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