Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis

Koichiro Sakaguchi, Shunsuke Furukawa, Takushige Katsura, Kyoko Yamazaki, Hideo Kawaguchi, Atsushi Maki, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The concentration changes in oxygenated haemoglobin and deoxygenated haemoglobin in the brain cortex of guinea pigs associated with brain activation are measured from the multi-spectral images of the cortical tissue. The cortical tissue is observed through a thinned skull. The wavelength dependence of the optical path length is considered in the calculation of haemoglobin concentration. The results are compared with those obtained from the multi-spectral images of the exposed cortex to evaluate the influence of the thinned skull on the measurement of the concentration changes by multispectral imaging system. Although the skull thickness affected the sensitivity of the change in reflectance due to decrease in optical path in the cortical tissue, the influence of skull on the wavelength dependence of the optical path length can be ignored when the skull thickness is approximately less than 100 μm.

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2007
PublisherOptical Society of America (OSA)
ISBN (Print)9780819467713
DOIs
Publication statusPublished - 2007
EventEuropean Conference on Biomedical Optics, ECBO 2007 - Munich, Germany
Duration: 2007 Jun 172007 Jun 17

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701

Other

OtherEuropean Conference on Biomedical Optics, ECBO 2007
CountryGermany
CityMunich
Period07/6/1707/6/17

Keywords

  • Cranial window
  • Multi-spectral imaging
  • Optical path length
  • Thinned skull

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

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