Pathologic support for limited hepatectomy in the treatment of liver metastases from colorectal cancer

J. Yamamoto, K. Sugihara, T. Kosuge, T. Takayama, K. Shimada, S. Yamasaki, Michiie Sakamoto, S. Hirohashi

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Objective: The authors determined an appropriate surgical treatment for liver metastases from colorectal cancers. Clinicopathologic features of metastatic lesions of colorectal cancers were studied. Summary Background Data: Major hepatic resection is the usual procedure for treatment of hepatic metastases from colorectal cancers. Methods: Forty consecutive patients who underwent hepatic resections were prospectively studied, for a total of 89 metastatic liver tumors. Results: Metastatic tumor often extended along Glisson's capsule, including invasion to the portal vein (9 cases), the hepatic vein (3 cases), the bile duct (16 cases), and the nerve (6 cases). The main tumor had small satellite nodules in only one patient, and there were no microscopic deposits in the parenchyma, even within 10 mm from the metastatic tumors. Fibrous pseudocapsule formation was observed in 28 patients. Discussion: The rarity of intrahepatic metastasis from metastatic tumor supports nonanatomic limited hepatic resection as the procedure of choice for metastatic colorectal cancer in the liver. The spread via Glisson's capsule should be taken into consideration for complete tumor clearance.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalAnnals of Surgery
Volume221
Issue number1
Publication statusPublished - 1995
Externally publishedYes

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Hepatectomy
Colorectal Neoplasms
Neoplasm Metastasis
Liver
Neoplasms
Capsules
Therapeutics
Hepatic Veins
Liver Neoplasms
Portal Vein
Bile Ducts

ASJC Scopus subject areas

  • Surgery

Cite this

Yamamoto, J., Sugihara, K., Kosuge, T., Takayama, T., Shimada, K., Yamasaki, S., ... Hirohashi, S. (1995). Pathologic support for limited hepatectomy in the treatment of liver metastases from colorectal cancer. Annals of Surgery, 221(1), 74-78.

Pathologic support for limited hepatectomy in the treatment of liver metastases from colorectal cancer. / Yamamoto, J.; Sugihara, K.; Kosuge, T.; Takayama, T.; Shimada, K.; Yamasaki, S.; Sakamoto, Michiie; Hirohashi, S.

In: Annals of Surgery, Vol. 221, No. 1, 1995, p. 74-78.

Research output: Contribution to journalArticle

Yamamoto, J, Sugihara, K, Kosuge, T, Takayama, T, Shimada, K, Yamasaki, S, Sakamoto, M & Hirohashi, S 1995, 'Pathologic support for limited hepatectomy in the treatment of liver metastases from colorectal cancer', Annals of Surgery, vol. 221, no. 1, pp. 74-78.
Yamamoto J, Sugihara K, Kosuge T, Takayama T, Shimada K, Yamasaki S et al. Pathologic support for limited hepatectomy in the treatment of liver metastases from colorectal cancer. Annals of Surgery. 1995;221(1):74-78.
Yamamoto, J. ; Sugihara, K. ; Kosuge, T. ; Takayama, T. ; Shimada, K. ; Yamasaki, S. ; Sakamoto, Michiie ; Hirohashi, S. / Pathologic support for limited hepatectomy in the treatment of liver metastases from colorectal cancer. In: Annals of Surgery. 1995 ; Vol. 221, No. 1. pp. 74-78.
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AU - Yamamoto, J.

AU - Sugihara, K.

AU - Kosuge, T.

AU - Takayama, T.

AU - Shimada, K.

AU - Yamasaki, S.

AU - Sakamoto, Michiie

AU - Hirohashi, S.

PY - 1995

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N2 - Objective: The authors determined an appropriate surgical treatment for liver metastases from colorectal cancers. Clinicopathologic features of metastatic lesions of colorectal cancers were studied. Summary Background Data: Major hepatic resection is the usual procedure for treatment of hepatic metastases from colorectal cancers. Methods: Forty consecutive patients who underwent hepatic resections were prospectively studied, for a total of 89 metastatic liver tumors. Results: Metastatic tumor often extended along Glisson's capsule, including invasion to the portal vein (9 cases), the hepatic vein (3 cases), the bile duct (16 cases), and the nerve (6 cases). The main tumor had small satellite nodules in only one patient, and there were no microscopic deposits in the parenchyma, even within 10 mm from the metastatic tumors. Fibrous pseudocapsule formation was observed in 28 patients. Discussion: The rarity of intrahepatic metastasis from metastatic tumor supports nonanatomic limited hepatic resection as the procedure of choice for metastatic colorectal cancer in the liver. The spread via Glisson's capsule should be taken into consideration for complete tumor clearance.

AB - Objective: The authors determined an appropriate surgical treatment for liver metastases from colorectal cancers. Clinicopathologic features of metastatic lesions of colorectal cancers were studied. Summary Background Data: Major hepatic resection is the usual procedure for treatment of hepatic metastases from colorectal cancers. Methods: Forty consecutive patients who underwent hepatic resections were prospectively studied, for a total of 89 metastatic liver tumors. Results: Metastatic tumor often extended along Glisson's capsule, including invasion to the portal vein (9 cases), the hepatic vein (3 cases), the bile duct (16 cases), and the nerve (6 cases). The main tumor had small satellite nodules in only one patient, and there were no microscopic deposits in the parenchyma, even within 10 mm from the metastatic tumors. Fibrous pseudocapsule formation was observed in 28 patients. Discussion: The rarity of intrahepatic metastasis from metastatic tumor supports nonanatomic limited hepatic resection as the procedure of choice for metastatic colorectal cancer in the liver. The spread via Glisson's capsule should be taken into consideration for complete tumor clearance.

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