Pathological complete response in advanced gastric carcinoma by S-1/CDDP combination chemotherapy

Fumiki Toriumi; Shigenori Ei; Hidena Takahashi; Rei Okada; Kyohei Masai; Mikiko Mito; Naoki Ishimaru; Katsuhiko Mizuno; Kan Handa; Takahiro Yamanashi; Yoshitomo Koshida; Hidetoshi Akamatsu; Katsuhiko Motegi; Toshihide Tajima; Kiyoshi Mukai; Yutaka Shimoyama

Pathological complete response in advanced gastric carcinoma by S-1/CDDP combination chemotherapy

Fumiki Toriumi, Shigenori Ei, Hidena Takahashi, Rei Okada, Kyohei Masai, Mikiko Mito, Naoki Ishimaru, Katsuhiko Mizuno, Kan Handa, Takahiro Yamanashi, Yoshitomo Koshida, Hidetoshi Akamatsu, Katsuhiko Motegi, Toshihide Tajima, Kiyoshi Mukai, Yutaka Shimoyama

Research output: Contribution to journal › Article › peer-review

Abstract

A 59-year-old woman was referred to our hospital for a close examination and treatment of an advanced gastric carcinoma. A physical examination and CT scan showed that the right cervical and axillar lymph nodes were swelling, and a histopathological examination of the axillar lymph node revealed metastatic growth of the gastric carcinoma (Stage IV). Then, we started S-1/CDDP combination chemotherapy. S-1 (80 mg/m²/day) was orally administered for 3 weeks followed by 2 weeks of rest, and CDDP (60 mg/m²) was administered by drip on day 8. Since the distant metastases were greatly reduced after 6 courses of combination therapy, a distal gastrectomy with lymph nodes dissection (D2) was performed. Histopathological examination of the resected tissues revealed no residual cancer cells, suggesting a pathologically complete response. The clinical course after the operation went well without any complications, and the patient is alive with no evidence of recurrence 1 year after surgery. S-1/CDDP combination chemotherapy appears to be one of the effective treatments for advanced gastric carcinoma.

Original language	English
Pages (from-to)	1183-1186
Number of pages	4
Journal	Japanese Journal of Cancer and Chemotherapy
Volume	38
Issue number	7
Publication status	Published - 2011 Jul 6
Externally published	Yes

Keywords

CDDP
Gastric carcinoma
Pathological CR
S-1

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Pathological complete response in advanced gastric carcinoma by S-1/CDDP combination chemotherapy",

abstract = "A 59-year-old woman was referred to our hospital for a close examination and treatment of an advanced gastric carcinoma. A physical examination and CT scan showed that the right cervical and axillar lymph nodes were swelling, and a histopathological examination of the axillar lymph node revealed metastatic growth of the gastric carcinoma (Stage IV). Then, we started S-1/CDDP combination chemotherapy. S-1 (80 mg/m2/day) was orally administered for 3 weeks followed by 2 weeks of rest, and CDDP (60 mg/m2) was administered by drip on day 8. Since the distant metastases were greatly reduced after 6 courses of combination therapy, a distal gastrectomy with lymph nodes dissection (D2) was performed. Histopathological examination of the resected tissues revealed no residual cancer cells, suggesting a pathologically complete response. The clinical course after the operation went well without any complications, and the patient is alive with no evidence of recurrence 1 year after surgery. S-1/CDDP combination chemotherapy appears to be one of the effective treatments for advanced gastric carcinoma.",

keywords = "CDDP, Gastric carcinoma, Pathological CR, S-1",

author = "Fumiki Toriumi and Shigenori Ei and Hidena Takahashi and Rei Okada and Kyohei Masai and Mikiko Mito and Naoki Ishimaru and Katsuhiko Mizuno and Kan Handa and Takahiro Yamanashi and Yoshitomo Koshida and Hidetoshi Akamatsu and Katsuhiko Motegi and Toshihide Tajima and Kiyoshi Mukai and Yutaka Shimoyama",

year = "2011",

month = jul,

day = "6",

language = "English",

volume = "38",

pages = "1183--1186",

journal = "Japanese Journal of Cancer and Chemotherapy",

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publisher = "Japanese Journal of Cancer and Chemotherapy Publishers Inc.",

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TY - JOUR

T1 - Pathological complete response in advanced gastric carcinoma by S-1/CDDP combination chemotherapy

AU - Toriumi, Fumiki

AU - Ei, Shigenori

AU - Takahashi, Hidena

AU - Okada, Rei

AU - Masai, Kyohei

AU - Mito, Mikiko

AU - Ishimaru, Naoki

AU - Mizuno, Katsuhiko

AU - Handa, Kan

AU - Yamanashi, Takahiro

AU - Koshida, Yoshitomo

AU - Akamatsu, Hidetoshi

AU - Motegi, Katsuhiko

AU - Tajima, Toshihide

AU - Mukai, Kiyoshi

AU - Shimoyama, Yutaka

PY - 2011/7/6

Y1 - 2011/7/6

N2 - A 59-year-old woman was referred to our hospital for a close examination and treatment of an advanced gastric carcinoma. A physical examination and CT scan showed that the right cervical and axillar lymph nodes were swelling, and a histopathological examination of the axillar lymph node revealed metastatic growth of the gastric carcinoma (Stage IV). Then, we started S-1/CDDP combination chemotherapy. S-1 (80 mg/m2/day) was orally administered for 3 weeks followed by 2 weeks of rest, and CDDP (60 mg/m2) was administered by drip on day 8. Since the distant metastases were greatly reduced after 6 courses of combination therapy, a distal gastrectomy with lymph nodes dissection (D2) was performed. Histopathological examination of the resected tissues revealed no residual cancer cells, suggesting a pathologically complete response. The clinical course after the operation went well without any complications, and the patient is alive with no evidence of recurrence 1 year after surgery. S-1/CDDP combination chemotherapy appears to be one of the effective treatments for advanced gastric carcinoma.

AB - A 59-year-old woman was referred to our hospital for a close examination and treatment of an advanced gastric carcinoma. A physical examination and CT scan showed that the right cervical and axillar lymph nodes were swelling, and a histopathological examination of the axillar lymph node revealed metastatic growth of the gastric carcinoma (Stage IV). Then, we started S-1/CDDP combination chemotherapy. S-1 (80 mg/m2/day) was orally administered for 3 weeks followed by 2 weeks of rest, and CDDP (60 mg/m2) was administered by drip on day 8. Since the distant metastases were greatly reduced after 6 courses of combination therapy, a distal gastrectomy with lymph nodes dissection (D2) was performed. Histopathological examination of the resected tissues revealed no residual cancer cells, suggesting a pathologically complete response. The clinical course after the operation went well without any complications, and the patient is alive with no evidence of recurrence 1 year after surgery. S-1/CDDP combination chemotherapy appears to be one of the effective treatments for advanced gastric carcinoma.

KW - CDDP

KW - Gastric carcinoma

KW - Pathological CR

KW - S-1

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M3 - Article

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AN - SCOPUS:80052723063

SN - 0385-0684

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JO - Japanese Journal of Cancer and Chemotherapy

JF - Japanese Journal of Cancer and Chemotherapy

IS - 7

ER -

Pathological complete response in advanced gastric carcinoma by S-1/CDDP combination chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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