Pathological Roles of Iron in Cardiovascular Disease

Motoi Kobayashi, Tomohiro Suhara, Yuichi Baba, Nicholas K. Kawasaki, Jason K. Higa, Takashi Matsui

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Iron is an essential mineral required for a variety of vital biological functions. Despite being vital for life, iron also has potentially toxic aspects. Iron has been investigated as a risk factor for coronary artery disease (CAD), however, iron's toxicity in CAD patients still remains controversial. One possible mechanism behind the toxicity of iron is "ferroptosis", a newly described form of irondependent cell death. Ferroptosis is an iron-dependent form of regulated cell death that is distinct from apoptosis, necroptosis, and other types of cell death. Ferroptosis has been reported in ischemiareperfusion (I/R) injury and several other diseases. Recently, we reported that ferroptosis is a significant form of cell death in cardiomyocytes. Moreover, myocardial hemorrhage, a major event in the pathogenesis of heart failure, could trigger the release of free iron into cardiac muscle and is an independent predictor of adverse left ventricular remodeling after myocardial infarction. Iron deposition in the heart can now be detected with advanced imaging methods, such as T2 star (T2*) cardiac magnetic resonance imaging, which can non-invasively predict iron levels in the myocardium and detect myocardial hemorrhage, thus existing technology could be used to assess myocardial iron. We will discuss the role of iron in cardiovascular diseases and especially with regard to myocardial I/R injury.

Original languageEnglish
Pages (from-to)1068-1076
Number of pages9
JournalCurrent drug targets
Volume19
Issue number9
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Cardiovascular Diseases
Iron
Cell death
Cell Death
Toxicity
Coronary Artery Disease
Myocardium
Hemorrhage
Imaging techniques
Ventricular Remodeling
Poisons
Wounds and Injuries
Magnetic resonance
Cardiac Myocytes
Stars
Minerals
Muscle
Heart Failure
Myocardial Infarction
Magnetic Resonance Imaging

Keywords

  • ferroptosis
  • iron
  • ischemia-reperfusion injury
  • Myocardial infarction
  • reactive oxygen species.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Kobayashi, M., Suhara, T., Baba, Y., Kawasaki, N. K., Higa, J. K., & Matsui, T. (2018). Pathological Roles of Iron in Cardiovascular Disease. Current drug targets, 19(9), 1068-1076. https://doi.org/10.2174/1389450119666180605112235

Pathological Roles of Iron in Cardiovascular Disease. / Kobayashi, Motoi; Suhara, Tomohiro; Baba, Yuichi; Kawasaki, Nicholas K.; Higa, Jason K.; Matsui, Takashi.

In: Current drug targets, Vol. 19, No. 9, 01.01.2018, p. 1068-1076.

Research output: Contribution to journalArticle

Kobayashi, M, Suhara, T, Baba, Y, Kawasaki, NK, Higa, JK & Matsui, T 2018, 'Pathological Roles of Iron in Cardiovascular Disease', Current drug targets, vol. 19, no. 9, pp. 1068-1076. https://doi.org/10.2174/1389450119666180605112235
Kobayashi, Motoi ; Suhara, Tomohiro ; Baba, Yuichi ; Kawasaki, Nicholas K. ; Higa, Jason K. ; Matsui, Takashi. / Pathological Roles of Iron in Cardiovascular Disease. In: Current drug targets. 2018 ; Vol. 19, No. 9. pp. 1068-1076.
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