Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease: The Ophelia syndrome

Toshiya Shinohara, Hideaki Kojima, Nishio Nakamura, Akihiko Ogata, Tomoko Betsuyaku, Akihiko Suzuki, Youichi Maki, Kazuo Nagashima

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

An archive autopsy case of a 50-year-old man who died of Hodgkin's lymphoma had a 4-year, 4-month history of dementia. After radiochemotherapy, the lymphoma subsided except for involvement of the spleen, but the dementia remained. Neuropathological examination revealed that the pathology was confined to the hippocampus, both hippocampi showing sclerosis without inflammation. Neurons of sector cornu ammonis (CA) 1 were completely lost whereas moderate neuron loss was also observed in sectors CA3 and 4, and the dentate gyrus. Neurons of sector CA2 were relatively well preserved and the subiculum was intact. There was no evidence of global hypoxia, or of neurodegenerative disorders with pathological changes affecting the hippocampus. Although there was a long preneoplastic history, and no inflammatory changes were found at autopsy, the present case of hippocampal sclerosis could be included in the category of paraneoplastic limbic encephalitis associated with Hodgkin's lymphoma or the Ophelia syndrome.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalNeuropathology
Volume25
Issue number4
DOIs
Publication statusPublished - 2005 Dec
Externally publishedYes

Fingerprint

Sclerosis
Hodgkin Disease
Dementia
Hippocampus
Pathology
Neurons
Autopsy
Limbic Encephalitis
Dentate Gyrus
Chemoradiotherapy
Neurodegenerative Diseases
Lymphoma
Spleen
History
Inflammation

Keywords

  • Dementia and amnesia
  • Hippocampal sclerosis
  • Hodgkin's lymphoma
  • Paraneoplastic limbic encephalitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Shinohara, T., Kojima, H., Nakamura, N., Ogata, A., Betsuyaku, T., Suzuki, A., ... Nagashima, K. (2005). Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease: The Ophelia syndrome. Neuropathology, 25(4), 353-360. https://doi.org/10.1111/j.1440-1789.2005.00622.x

Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease : The Ophelia syndrome. / Shinohara, Toshiya; Kojima, Hideaki; Nakamura, Nishio; Ogata, Akihiko; Betsuyaku, Tomoko; Suzuki, Akihiko; Maki, Youichi; Nagashima, Kazuo.

In: Neuropathology, Vol. 25, No. 4, 12.2005, p. 353-360.

Research output: Contribution to journalArticle

Shinohara, T, Kojima, H, Nakamura, N, Ogata, A, Betsuyaku, T, Suzuki, A, Maki, Y & Nagashima, K 2005, 'Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease: The Ophelia syndrome', Neuropathology, vol. 25, no. 4, pp. 353-360. https://doi.org/10.1111/j.1440-1789.2005.00622.x
Shinohara, Toshiya ; Kojima, Hideaki ; Nakamura, Nishio ; Ogata, Akihiko ; Betsuyaku, Tomoko ; Suzuki, Akihiko ; Maki, Youichi ; Nagashima, Kazuo. / Pathology of pure hippocampal sclerosis in a patient with dementia and Hodgkin's disease : The Ophelia syndrome. In: Neuropathology. 2005 ; Vol. 25, No. 4. pp. 353-360.
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