Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women: analysis of 41 cases in Japan

Asuka Morikawa, Kazu Ueda, Kazuaki Takahashi, Masaharu Fukunaga, Mitsutoshi Iwashita, Yoichi Kobayashi, Kimihiro Takechi, Satoshi Umezawa, Fumitoshi Terauchi, Kazushige Kiguchi, Daisuke Aoki, Hiroyuki Nomura, Hiroyuki Yoshikawa, Toyomi Satoh, Toshiko Jobo, Hiroyuki Fujiwara, Yuji Takei, Seiryu Kamoi, Yasuhisa Terao, Seiji Isonishi

Research output: Contribution to journalArticle

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Abstract

Background: The aim of this study was to investigate the impact of the histological findings on the treatment of malignant ovarian tumors in pregnant women.

Methods: This is a retrospective study of 41 patients diagnosed and treated for ovarian malignancy during pregnancy between 1985 and 2010.

Results: The median age of the study group was 30 years old, ranging from 20 to 41. Thirty-eight (92 %) patients were diagnosed with stage I, and one (2 %) with each of stages II, III, and IV. Twenty-five (61 %) patients had borderline malignancy, 8 (20 %) were diagnosed with epithelial ovarian cancer, 7 (17 %) with germ cell tumor, and one with sex cord stromal tumor. All patients received primary surgery; 7 (17 %) patients had cystectomy, 32 (78 %) had unilateral salpingo-oophorectomy, and 3 (7 %) underwent hysterectomy with bilateral salpingo-oophorectomy. Thirty-one (76 %) patients delivered live newborns; 21 had borderline tumor (84 %), 2 had ovarian cancers (25 %), and 8 had non-epithelial tumor (100 %). Six cases were terminated in order to perform the standard treatment for ovarian malignancy and 2 cases aborted spontaneously.

Conclusion: In pregnant women, ovarian cancer is exceptionally less frequent compared with non-pregnant women, i.e. age-matched, statistically-corrected controls based on the Japanese annual report [8/33 (24 %) vs. control (60 %); ovarian cancer/(ovarian cancer + borderline tumor), P = 0.001]. The pregnant women with ovarian cancer chose to prioritize treatment of ovarian cancer at the sacrifice of their babies while those with borderline tumor or non-epithelial tumor were able to successfully deliver live newborns.

Original languageEnglish
Pages (from-to)1074-1079
Number of pages6
JournalInternational Journal of Clinical Oncology
Volume19
Issue number6
DOIs
Publication statusPublished - 2014 Dec 10

Fingerprint

Pregnant Women
Japan
Pathology
Ovarian Neoplasms
Neoplasms
Therapeutics
Ovariectomy
Sex Cord-Gonadal Stromal Tumors
Newborn Infant
Annual Reports
Germ Cell and Embryonal Neoplasms
Cystectomy
Hysterectomy
Retrospective Studies
Age Groups
Pregnancy

Keywords

  • Ovarian cancer
  • Pathology
  • Preganancy
  • Progesterone

ASJC Scopus subject areas

  • Oncology
  • Surgery
  • Hematology

Cite this

Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women : analysis of 41 cases in Japan. / Morikawa, Asuka; Ueda, Kazu; Takahashi, Kazuaki; Fukunaga, Masaharu; Iwashita, Mitsutoshi; Kobayashi, Yoichi; Takechi, Kimihiro; Umezawa, Satoshi; Terauchi, Fumitoshi; Kiguchi, Kazushige; Aoki, Daisuke; Nomura, Hiroyuki; Yoshikawa, Hiroyuki; Satoh, Toyomi; Jobo, Toshiko; Fujiwara, Hiroyuki; Takei, Yuji; Kamoi, Seiryu; Terao, Yasuhisa; Isonishi, Seiji.

In: International Journal of Clinical Oncology, Vol. 19, No. 6, 10.12.2014, p. 1074-1079.

Research output: Contribution to journalArticle

Morikawa, A, Ueda, K, Takahashi, K, Fukunaga, M, Iwashita, M, Kobayashi, Y, Takechi, K, Umezawa, S, Terauchi, F, Kiguchi, K, Aoki, D, Nomura, H, Yoshikawa, H, Satoh, T, Jobo, T, Fujiwara, H, Takei, Y, Kamoi, S, Terao, Y & Isonishi, S 2014, 'Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women: analysis of 41 cases in Japan', International Journal of Clinical Oncology, vol. 19, no. 6, pp. 1074-1079. https://doi.org/10.1007/s10147-014-0669-3
Morikawa, Asuka ; Ueda, Kazu ; Takahashi, Kazuaki ; Fukunaga, Masaharu ; Iwashita, Mitsutoshi ; Kobayashi, Yoichi ; Takechi, Kimihiro ; Umezawa, Satoshi ; Terauchi, Fumitoshi ; Kiguchi, Kazushige ; Aoki, Daisuke ; Nomura, Hiroyuki ; Yoshikawa, Hiroyuki ; Satoh, Toyomi ; Jobo, Toshiko ; Fujiwara, Hiroyuki ; Takei, Yuji ; Kamoi, Seiryu ; Terao, Yasuhisa ; Isonishi, Seiji. / Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women : analysis of 41 cases in Japan. In: International Journal of Clinical Oncology. 2014 ; Vol. 19, No. 6. pp. 1074-1079.
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abstract = "Background: The aim of this study was to investigate the impact of the histological findings on the treatment of malignant ovarian tumors in pregnant women.Methods: This is a retrospective study of 41 patients diagnosed and treated for ovarian malignancy during pregnancy between 1985 and 2010.Results: The median age of the study group was 30 years old, ranging from 20 to 41. Thirty-eight (92 {\%}) patients were diagnosed with stage I, and one (2 {\%}) with each of stages II, III, and IV. Twenty-five (61 {\%}) patients had borderline malignancy, 8 (20 {\%}) were diagnosed with epithelial ovarian cancer, 7 (17 {\%}) with germ cell tumor, and one with sex cord stromal tumor. All patients received primary surgery; 7 (17 {\%}) patients had cystectomy, 32 (78 {\%}) had unilateral salpingo-oophorectomy, and 3 (7 {\%}) underwent hysterectomy with bilateral salpingo-oophorectomy. Thirty-one (76 {\%}) patients delivered live newborns; 21 had borderline tumor (84 {\%}), 2 had ovarian cancers (25 {\%}), and 8 had non-epithelial tumor (100 {\%}). Six cases were terminated in order to perform the standard treatment for ovarian malignancy and 2 cases aborted spontaneously.Conclusion: In pregnant women, ovarian cancer is exceptionally less frequent compared with non-pregnant women, i.e. age-matched, statistically-corrected controls based on the Japanese annual report [8/33 (24 {\%}) vs. control (60 {\%}); ovarian cancer/(ovarian cancer + borderline tumor), P = 0.001]. The pregnant women with ovarian cancer chose to prioritize treatment of ovarian cancer at the sacrifice of their babies while those with borderline tumor or non-epithelial tumor were able to successfully deliver live newborns.",
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AU - Morikawa, Asuka

AU - Ueda, Kazu

AU - Takahashi, Kazuaki

AU - Fukunaga, Masaharu

AU - Iwashita, Mitsutoshi

AU - Kobayashi, Yoichi

AU - Takechi, Kimihiro

AU - Umezawa, Satoshi

AU - Terauchi, Fumitoshi

AU - Kiguchi, Kazushige

AU - Aoki, Daisuke

AU - Nomura, Hiroyuki

AU - Yoshikawa, Hiroyuki

AU - Satoh, Toyomi

AU - Jobo, Toshiko

AU - Fujiwara, Hiroyuki

AU - Takei, Yuji

AU - Kamoi, Seiryu

AU - Terao, Yasuhisa

AU - Isonishi, Seiji

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N2 - Background: The aim of this study was to investigate the impact of the histological findings on the treatment of malignant ovarian tumors in pregnant women.Methods: This is a retrospective study of 41 patients diagnosed and treated for ovarian malignancy during pregnancy between 1985 and 2010.Results: The median age of the study group was 30 years old, ranging from 20 to 41. Thirty-eight (92 %) patients were diagnosed with stage I, and one (2 %) with each of stages II, III, and IV. Twenty-five (61 %) patients had borderline malignancy, 8 (20 %) were diagnosed with epithelial ovarian cancer, 7 (17 %) with germ cell tumor, and one with sex cord stromal tumor. All patients received primary surgery; 7 (17 %) patients had cystectomy, 32 (78 %) had unilateral salpingo-oophorectomy, and 3 (7 %) underwent hysterectomy with bilateral salpingo-oophorectomy. Thirty-one (76 %) patients delivered live newborns; 21 had borderline tumor (84 %), 2 had ovarian cancers (25 %), and 8 had non-epithelial tumor (100 %). Six cases were terminated in order to perform the standard treatment for ovarian malignancy and 2 cases aborted spontaneously.Conclusion: In pregnant women, ovarian cancer is exceptionally less frequent compared with non-pregnant women, i.e. age-matched, statistically-corrected controls based on the Japanese annual report [8/33 (24 %) vs. control (60 %); ovarian cancer/(ovarian cancer + borderline tumor), P = 0.001]. The pregnant women with ovarian cancer chose to prioritize treatment of ovarian cancer at the sacrifice of their babies while those with borderline tumor or non-epithelial tumor were able to successfully deliver live newborns.

AB - Background: The aim of this study was to investigate the impact of the histological findings on the treatment of malignant ovarian tumors in pregnant women.Methods: This is a retrospective study of 41 patients diagnosed and treated for ovarian malignancy during pregnancy between 1985 and 2010.Results: The median age of the study group was 30 years old, ranging from 20 to 41. Thirty-eight (92 %) patients were diagnosed with stage I, and one (2 %) with each of stages II, III, and IV. Twenty-five (61 %) patients had borderline malignancy, 8 (20 %) were diagnosed with epithelial ovarian cancer, 7 (17 %) with germ cell tumor, and one with sex cord stromal tumor. All patients received primary surgery; 7 (17 %) patients had cystectomy, 32 (78 %) had unilateral salpingo-oophorectomy, and 3 (7 %) underwent hysterectomy with bilateral salpingo-oophorectomy. Thirty-one (76 %) patients delivered live newborns; 21 had borderline tumor (84 %), 2 had ovarian cancers (25 %), and 8 had non-epithelial tumor (100 %). Six cases were terminated in order to perform the standard treatment for ovarian malignancy and 2 cases aborted spontaneously.Conclusion: In pregnant women, ovarian cancer is exceptionally less frequent compared with non-pregnant women, i.e. age-matched, statistically-corrected controls based on the Japanese annual report [8/33 (24 %) vs. control (60 %); ovarian cancer/(ovarian cancer + borderline tumor), P = 0.001]. The pregnant women with ovarian cancer chose to prioritize treatment of ovarian cancer at the sacrifice of their babies while those with borderline tumor or non-epithelial tumor were able to successfully deliver live newborns.

KW - Ovarian cancer

KW - Pathology

KW - Preganancy

KW - Progesterone

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