Pathophysiological Roles of G-CSF

K. Ozawa, K. Watari, T. Tsuruta, S. Takahashi, H. Ogura, T. Yoshikubo, M. Nishikawa, M. Shimane, S. Okamoto, A. Tojo, K. Tani, S. Asano

Research output: Contribution to journalArticle

Abstract

G-CSF is produced by a variety of cells. In situ hybridization showed that only a small proportion of stromal cells expressed G-CSF after stimulation with LPS or IL-1. The measurement of serum G-CSF level by enzyme immunoassay provided valuable information as to the pathophysiological roles of G-CSF. In aplastic anemia, there was an inverse correlation between blood neutrophil count and serum G-CSF level. Similarly, the G-CSF level rose during the neutropenic phase of cyclic neutropenia. These findings suggest that the serum G-CSF level is regulated by a feedback mechanism. In some cases, the reduced G-CSF production by stromal cells may underlie the pathogenesis of neutropenia. On the other hand, infections and cancers sometimes caused high serum G-CSF levels in association with increased blood neutrophils, presumably reflecting reactive and aberrant production of G-CSF, respectively. Expression of G-CSF by myeloid leukemia cells may partly contribute to their abnormal growth through the autocrine mechanism.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalJournal of nutritional science and vitaminology
Volume38
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Ozawa, K., Watari, K., Tsuruta, T., Takahashi, S., Ogura, H., Yoshikubo, T., Nishikawa, M., Shimane, M., Okamoto, S., Tojo, A., Tani, K., & Asano, S. (1992). Pathophysiological Roles of G-CSF. Journal of nutritional science and vitaminology, 38, 345-348. https://doi.org/10.3177/jnsv.38.Special_345