Patient age was an independent predictor of cancer-specific survival in male patients with upper tract urothelial carcinoma treated by radical nephroureterectomy

Hiroaki Kobayashi, Eiji Kikuchi, Nobuyuki Tanaka, Suguru Shirotake, Yasumasa Miyazaki, Hiroki Ide, Jun Obata, Katsura Hoshino, Kazuhiro Matsumoto, Gou Kaneko, Masayuki Hagiwara, Takeo Kosaka, Masafumi Oyama, Yosuke Nakajima, Mototsugu Oya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: We hypothesized that there may be a prognostic difference in age between the genders and evaluated the influence of gender-adjusted age on prognosis in upper tract urothelial carcinoma patients. Methods: A total of 839 patients with upper tract urothelial carcinoma from a retrospective multi-institutional cohort were included. The patients were divided into four groups consisting of males (N = 610) and females (N = 229) according to age ((i) <60 years, (ii) 60-69.9 years, (iii) 70-79.9 years and (iv) ≥ 80 years), and we evaluated the associations of patient age and gender with clinicopathological features and oncological outcomes following radical nephroureterectomy. The median follow-up duration was 34 months. Results: Disease recurrence occurred in 249 patients and 192 patients died of upper tract urothelial carcinoma. The 3-year cancer-specific survival rates were (i) 84.3%, (ii) 80.2%, (iii) 77.1% and (iv) 71.5% in the entire patient population (P = 0.001); (i) 84.5%, (ii) 81.1%, (iii) 76.8% and (iv) 69.7% in males (P = 0.010); and (i) 83.3%, (ii) 76.9%, (iii) 77.7% and (iv) 72.9% in females (P = 0.287), respectively. No significant differences between disease recurrence and age were found in the male or female population. In multivariate analysis, older age was an independent predictor of cancer-specific survival, in addition to advanced pT stage, the presence of lymphovascular invasion and lymph node involvement in males. In contrast, age was not associated with cancer-specific survival in females, while high grade, advanced pT stage, the presence of lymph node involvement and multifocal tumor were independent predictors. Conclusion: The results indicate that gender-adjusted age might be a new prognostic factor in upper tract urothelial carcinoma patients.

Original languageEnglish
Article numberhyw028
Pages (from-to)554-559
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume46
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1

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Carcinoma
Survival
Neoplasms
Lymph Nodes
Recurrence
Population
Multivariate Analysis
Survival Rate

Keywords

  • Age
  • Gender
  • Radical nephroureterectomy
  • Upper urinary tract
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Patient age was an independent predictor of cancer-specific survival in male patients with upper tract urothelial carcinoma treated by radical nephroureterectomy. / Kobayashi, Hiroaki; Kikuchi, Eiji; Tanaka, Nobuyuki; Shirotake, Suguru; Miyazaki, Yasumasa; Ide, Hiroki; Obata, Jun; Hoshino, Katsura; Matsumoto, Kazuhiro; Kaneko, Gou; Hagiwara, Masayuki; Kosaka, Takeo; Oyama, Masafumi; Nakajima, Yosuke; Oya, Mototsugu.

In: Japanese Journal of Clinical Oncology, Vol. 46, No. 6, hyw028, 01.06.2016, p. 554-559.

Research output: Contribution to journalArticle

Kobayashi, Hiroaki ; Kikuchi, Eiji ; Tanaka, Nobuyuki ; Shirotake, Suguru ; Miyazaki, Yasumasa ; Ide, Hiroki ; Obata, Jun ; Hoshino, Katsura ; Matsumoto, Kazuhiro ; Kaneko, Gou ; Hagiwara, Masayuki ; Kosaka, Takeo ; Oyama, Masafumi ; Nakajima, Yosuke ; Oya, Mototsugu. / Patient age was an independent predictor of cancer-specific survival in male patients with upper tract urothelial carcinoma treated by radical nephroureterectomy. In: Japanese Journal of Clinical Oncology. 2016 ; Vol. 46, No. 6. pp. 554-559.
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abstract = "Objective: We hypothesized that there may be a prognostic difference in age between the genders and evaluated the influence of gender-adjusted age on prognosis in upper tract urothelial carcinoma patients. Methods: A total of 839 patients with upper tract urothelial carcinoma from a retrospective multi-institutional cohort were included. The patients were divided into four groups consisting of males (N = 610) and females (N = 229) according to age ((i) <60 years, (ii) 60-69.9 years, (iii) 70-79.9 years and (iv) ≥ 80 years), and we evaluated the associations of patient age and gender with clinicopathological features and oncological outcomes following radical nephroureterectomy. The median follow-up duration was 34 months. Results: Disease recurrence occurred in 249 patients and 192 patients died of upper tract urothelial carcinoma. The 3-year cancer-specific survival rates were (i) 84.3{\%}, (ii) 80.2{\%}, (iii) 77.1{\%} and (iv) 71.5{\%} in the entire patient population (P = 0.001); (i) 84.5{\%}, (ii) 81.1{\%}, (iii) 76.8{\%} and (iv) 69.7{\%} in males (P = 0.010); and (i) 83.3{\%}, (ii) 76.9{\%}, (iii) 77.7{\%} and (iv) 72.9{\%} in females (P = 0.287), respectively. No significant differences between disease recurrence and age were found in the male or female population. In multivariate analysis, older age was an independent predictor of cancer-specific survival, in addition to advanced pT stage, the presence of lymphovascular invasion and lymph node involvement in males. In contrast, age was not associated with cancer-specific survival in females, while high grade, advanced pT stage, the presence of lymph node involvement and multifocal tumor were independent predictors. Conclusion: The results indicate that gender-adjusted age might be a new prognostic factor in upper tract urothelial carcinoma patients.",
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AU - Kobayashi, Hiroaki

AU - Kikuchi, Eiji

AU - Tanaka, Nobuyuki

AU - Shirotake, Suguru

AU - Miyazaki, Yasumasa

AU - Ide, Hiroki

AU - Obata, Jun

AU - Hoshino, Katsura

AU - Matsumoto, Kazuhiro

AU - Kaneko, Gou

AU - Hagiwara, Masayuki

AU - Kosaka, Takeo

AU - Oyama, Masafumi

AU - Nakajima, Yosuke

AU - Oya, Mototsugu

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objective: We hypothesized that there may be a prognostic difference in age between the genders and evaluated the influence of gender-adjusted age on prognosis in upper tract urothelial carcinoma patients. Methods: A total of 839 patients with upper tract urothelial carcinoma from a retrospective multi-institutional cohort were included. The patients were divided into four groups consisting of males (N = 610) and females (N = 229) according to age ((i) <60 years, (ii) 60-69.9 years, (iii) 70-79.9 years and (iv) ≥ 80 years), and we evaluated the associations of patient age and gender with clinicopathological features and oncological outcomes following radical nephroureterectomy. The median follow-up duration was 34 months. Results: Disease recurrence occurred in 249 patients and 192 patients died of upper tract urothelial carcinoma. The 3-year cancer-specific survival rates were (i) 84.3%, (ii) 80.2%, (iii) 77.1% and (iv) 71.5% in the entire patient population (P = 0.001); (i) 84.5%, (ii) 81.1%, (iii) 76.8% and (iv) 69.7% in males (P = 0.010); and (i) 83.3%, (ii) 76.9%, (iii) 77.7% and (iv) 72.9% in females (P = 0.287), respectively. No significant differences between disease recurrence and age were found in the male or female population. In multivariate analysis, older age was an independent predictor of cancer-specific survival, in addition to advanced pT stage, the presence of lymphovascular invasion and lymph node involvement in males. In contrast, age was not associated with cancer-specific survival in females, while high grade, advanced pT stage, the presence of lymph node involvement and multifocal tumor were independent predictors. Conclusion: The results indicate that gender-adjusted age might be a new prognostic factor in upper tract urothelial carcinoma patients.

AB - Objective: We hypothesized that there may be a prognostic difference in age between the genders and evaluated the influence of gender-adjusted age on prognosis in upper tract urothelial carcinoma patients. Methods: A total of 839 patients with upper tract urothelial carcinoma from a retrospective multi-institutional cohort were included. The patients were divided into four groups consisting of males (N = 610) and females (N = 229) according to age ((i) <60 years, (ii) 60-69.9 years, (iii) 70-79.9 years and (iv) ≥ 80 years), and we evaluated the associations of patient age and gender with clinicopathological features and oncological outcomes following radical nephroureterectomy. The median follow-up duration was 34 months. Results: Disease recurrence occurred in 249 patients and 192 patients died of upper tract urothelial carcinoma. The 3-year cancer-specific survival rates were (i) 84.3%, (ii) 80.2%, (iii) 77.1% and (iv) 71.5% in the entire patient population (P = 0.001); (i) 84.5%, (ii) 81.1%, (iii) 76.8% and (iv) 69.7% in males (P = 0.010); and (i) 83.3%, (ii) 76.9%, (iii) 77.7% and (iv) 72.9% in females (P = 0.287), respectively. No significant differences between disease recurrence and age were found in the male or female population. In multivariate analysis, older age was an independent predictor of cancer-specific survival, in addition to advanced pT stage, the presence of lymphovascular invasion and lymph node involvement in males. In contrast, age was not associated with cancer-specific survival in females, while high grade, advanced pT stage, the presence of lymph node involvement and multifocal tumor were independent predictors. Conclusion: The results indicate that gender-adjusted age might be a new prognostic factor in upper tract urothelial carcinoma patients.

KW - Age

KW - Gender

KW - Radical nephroureterectomy

KW - Upper urinary tract

KW - Urothelial carcinoma

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