Pattern of tumor recurrence in initially nonmetastatic breast cancer patients: Distribution and frequency of metastases at unusual sites

Naoko Sanuki-Fujimoto, Atsuya Takeda, Atsushi Amemiya, Toru Ofuchi, Masato Ono, Ryo Yamagami, Jun Hatayama, Etsuo Kunieda, Naoyuki Shigematsu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BACKGROUND. Breast cancer is likely to have systemic involvement. However, to the authors' knowledge there are few reports to date regarding clinically detected patterns of metastasis, meticulously studied in regard to the natural history of breast cancer, including unusual sites of metastasis. METHODS. Patients treated for invasive breast cancer from April 1983 to May 2007 were retrospectively analyzed. Patterns of clinically apparent tumor recurrence, focusing especially on unusual metastases, were studied as well as possible risk factors for unusual metastases and their influence on survival. RESULTS. Overall, 3783 patients were eligible for the current analysis. The median duration of follow-up was 5.0 years (range, 0.6 years-20.4 years). Cumulative 5-year and 10-year survival rates were 89.7% and 81.5%, respectively. "Unusual metastasis" was defined as systemic failure with a frequency of ≤1%; in the current series; it was observed in 85 (2.2%) patients %. Of those, 70 (82%) had preceding metastasis in the usual sites. The median duration until the development of usual and unusual metastasis was 2.3 years and 3.6 years, respectively (P < .0001). Among 764 patients with distant metastasis, the 5-year cumulative overall survival rate in those with or without unusual metastasis was 53.5% and 53.4 years, respectively (P = .33). No risk factors for unusual metastasis were identified. CONCLUSIONS. This retrospective study examined the frequency of unusual metastases in a large number of Japanese patients with initially nonmetastatic breast cancer. The prognosis of patients with unusual metastases was found to be similar to that of patients with metastasis only at more usual sites.

Original languageEnglish
Pages (from-to)677-682
Number of pages6
JournalCancer
Volume113
Issue number4
DOIs
Publication statusPublished - 2008 Aug 15

Fingerprint

Breast Neoplasms
Neoplasm Metastasis
Recurrence
Neoplasms
Survival Rate
Retrospective Studies
Survival

Keywords

  • Breast cancer
  • Follow-up
  • Metastasis
  • Unusual metastasis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pattern of tumor recurrence in initially nonmetastatic breast cancer patients : Distribution and frequency of metastases at unusual sites. / Sanuki-Fujimoto, Naoko; Takeda, Atsuya; Amemiya, Atsushi; Ofuchi, Toru; Ono, Masato; Yamagami, Ryo; Hatayama, Jun; Kunieda, Etsuo; Shigematsu, Naoyuki.

In: Cancer, Vol. 113, No. 4, 15.08.2008, p. 677-682.

Research output: Contribution to journalArticle

Sanuki-Fujimoto, N, Takeda, A, Amemiya, A, Ofuchi, T, Ono, M, Yamagami, R, Hatayama, J, Kunieda, E & Shigematsu, N 2008, 'Pattern of tumor recurrence in initially nonmetastatic breast cancer patients: Distribution and frequency of metastases at unusual sites', Cancer, vol. 113, no. 4, pp. 677-682. https://doi.org/10.1002/cncr.23612
Sanuki-Fujimoto, Naoko ; Takeda, Atsuya ; Amemiya, Atsushi ; Ofuchi, Toru ; Ono, Masato ; Yamagami, Ryo ; Hatayama, Jun ; Kunieda, Etsuo ; Shigematsu, Naoyuki. / Pattern of tumor recurrence in initially nonmetastatic breast cancer patients : Distribution and frequency of metastases at unusual sites. In: Cancer. 2008 ; Vol. 113, No. 4. pp. 677-682.
@article{3e60ea2a4c9e4fdcad74fffe7a6e9123,
title = "Pattern of tumor recurrence in initially nonmetastatic breast cancer patients: Distribution and frequency of metastases at unusual sites",
abstract = "BACKGROUND. Breast cancer is likely to have systemic involvement. However, to the authors' knowledge there are few reports to date regarding clinically detected patterns of metastasis, meticulously studied in regard to the natural history of breast cancer, including unusual sites of metastasis. METHODS. Patients treated for invasive breast cancer from April 1983 to May 2007 were retrospectively analyzed. Patterns of clinically apparent tumor recurrence, focusing especially on unusual metastases, were studied as well as possible risk factors for unusual metastases and their influence on survival. RESULTS. Overall, 3783 patients were eligible for the current analysis. The median duration of follow-up was 5.0 years (range, 0.6 years-20.4 years). Cumulative 5-year and 10-year survival rates were 89.7{\%} and 81.5{\%}, respectively. {"}Unusual metastasis{"} was defined as systemic failure with a frequency of ≤1{\%}; in the current series; it was observed in 85 (2.2{\%}) patients {\%}. Of those, 70 (82{\%}) had preceding metastasis in the usual sites. The median duration until the development of usual and unusual metastasis was 2.3 years and 3.6 years, respectively (P < .0001). Among 764 patients with distant metastasis, the 5-year cumulative overall survival rate in those with or without unusual metastasis was 53.5{\%} and 53.4 years, respectively (P = .33). No risk factors for unusual metastasis were identified. CONCLUSIONS. This retrospective study examined the frequency of unusual metastases in a large number of Japanese patients with initially nonmetastatic breast cancer. The prognosis of patients with unusual metastases was found to be similar to that of patients with metastasis only at more usual sites.",
keywords = "Breast cancer, Follow-up, Metastasis, Unusual metastasis",
author = "Naoko Sanuki-Fujimoto and Atsuya Takeda and Atsushi Amemiya and Toru Ofuchi and Masato Ono and Ryo Yamagami and Jun Hatayama and Etsuo Kunieda and Naoyuki Shigematsu",
year = "2008",
month = "8",
day = "15",
doi = "10.1002/cncr.23612",
language = "English",
volume = "113",
pages = "677--682",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Pattern of tumor recurrence in initially nonmetastatic breast cancer patients

T2 - Distribution and frequency of metastases at unusual sites

AU - Sanuki-Fujimoto, Naoko

AU - Takeda, Atsuya

AU - Amemiya, Atsushi

AU - Ofuchi, Toru

AU - Ono, Masato

AU - Yamagami, Ryo

AU - Hatayama, Jun

AU - Kunieda, Etsuo

AU - Shigematsu, Naoyuki

PY - 2008/8/15

Y1 - 2008/8/15

N2 - BACKGROUND. Breast cancer is likely to have systemic involvement. However, to the authors' knowledge there are few reports to date regarding clinically detected patterns of metastasis, meticulously studied in regard to the natural history of breast cancer, including unusual sites of metastasis. METHODS. Patients treated for invasive breast cancer from April 1983 to May 2007 were retrospectively analyzed. Patterns of clinically apparent tumor recurrence, focusing especially on unusual metastases, were studied as well as possible risk factors for unusual metastases and their influence on survival. RESULTS. Overall, 3783 patients were eligible for the current analysis. The median duration of follow-up was 5.0 years (range, 0.6 years-20.4 years). Cumulative 5-year and 10-year survival rates were 89.7% and 81.5%, respectively. "Unusual metastasis" was defined as systemic failure with a frequency of ≤1%; in the current series; it was observed in 85 (2.2%) patients %. Of those, 70 (82%) had preceding metastasis in the usual sites. The median duration until the development of usual and unusual metastasis was 2.3 years and 3.6 years, respectively (P < .0001). Among 764 patients with distant metastasis, the 5-year cumulative overall survival rate in those with or without unusual metastasis was 53.5% and 53.4 years, respectively (P = .33). No risk factors for unusual metastasis were identified. CONCLUSIONS. This retrospective study examined the frequency of unusual metastases in a large number of Japanese patients with initially nonmetastatic breast cancer. The prognosis of patients with unusual metastases was found to be similar to that of patients with metastasis only at more usual sites.

AB - BACKGROUND. Breast cancer is likely to have systemic involvement. However, to the authors' knowledge there are few reports to date regarding clinically detected patterns of metastasis, meticulously studied in regard to the natural history of breast cancer, including unusual sites of metastasis. METHODS. Patients treated for invasive breast cancer from April 1983 to May 2007 were retrospectively analyzed. Patterns of clinically apparent tumor recurrence, focusing especially on unusual metastases, were studied as well as possible risk factors for unusual metastases and their influence on survival. RESULTS. Overall, 3783 patients were eligible for the current analysis. The median duration of follow-up was 5.0 years (range, 0.6 years-20.4 years). Cumulative 5-year and 10-year survival rates were 89.7% and 81.5%, respectively. "Unusual metastasis" was defined as systemic failure with a frequency of ≤1%; in the current series; it was observed in 85 (2.2%) patients %. Of those, 70 (82%) had preceding metastasis in the usual sites. The median duration until the development of usual and unusual metastasis was 2.3 years and 3.6 years, respectively (P < .0001). Among 764 patients with distant metastasis, the 5-year cumulative overall survival rate in those with or without unusual metastasis was 53.5% and 53.4 years, respectively (P = .33). No risk factors for unusual metastasis were identified. CONCLUSIONS. This retrospective study examined the frequency of unusual metastases in a large number of Japanese patients with initially nonmetastatic breast cancer. The prognosis of patients with unusual metastases was found to be similar to that of patients with metastasis only at more usual sites.

KW - Breast cancer

KW - Follow-up

KW - Metastasis

KW - Unusual metastasis

UR - http://www.scopus.com/inward/record.url?scp=50249122061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50249122061&partnerID=8YFLogxK

U2 - 10.1002/cncr.23612

DO - 10.1002/cncr.23612

M3 - Article

C2 - 18613072

AN - SCOPUS:50249122061

VL - 113

SP - 677

EP - 682

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 4

ER -