TY - JOUR
T1 - Patterns of functional connectivity alterations induced by alcohol reflect somatostatin interneuron expression in the human cerebral cortex
AU - Ochi, Ryo
AU - Ueno, Fumihiko
AU - Sakuma, Mutsuki
AU - Tani, Hideaki
AU - Tsugawa, Sakiko
AU - Graff-Guerrero, Ariel
AU - Uchida, Hiroyuki
AU - Mimura, Masaru
AU - Oshima, Shunji
AU - Matsushita, Sachio
AU - Nakajima, Shinichiro
N1 - Funding Information:
This research was funded by Asahi Quality and Innovations, Ltd. We thank Ms. Sachiko Hara, Ms. Mayumi Ogawa, Ms. Minori Tsukahara, and Ms. Mitsuko Kotake at the National Hospital Organization Kurihama Medical and Addiction Center for their assistance for conducting alcohol clamp method. Also, we thank Mr. Toshihiro Hagihara and Mr. Takuya Shintani at the National Hospital Organization Kurihama Medical and Addiction Center for their support for the acquisition of MRI data.
Funding Information:
This research was funded by Asahi Quality and Innovations, Ltd. We thank Ms. Sachiko Hara, Ms. Mayumi Ogawa, Ms. Minori Tsukahara, and Ms. Mitsuko Kotake at the National Hospital Organization Kurihama Medical and Addiction Center for their assistance for conducting alcohol clamp method. Also, we thank Mr. Toshihiro Hagihara and Mr. Takuya Shintani at the National Hospital Organization Kurihama Medical and Addiction Center for their support for the acquisition of MRI data.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Acute alcohol administration affects functional connectivity, yet the underlying mechanism is unknown. Previous work suggested that a moderate dose of alcohol reduces the activity of gamma-aminobutyric acidergic (GABAergic) interneurons, thereby leading to a state of pyramidal disinhibition and hyperexcitability. The present study aims to relate alcohol-induced changes in functional connectivity to regional genetic markers of GABAergic interneurons. Healthy young adults (N = 15, 5 males) underwent resting state functional MRI scanning prior to alcohol administration, immediately and 90 min after alcohol administration. Functional connectivity density mapping was performed to quantify alcohol-induced changes in resting brain activity between conditions. Patterns of differences between conditions were related to regional genetic markers that express the primary GABAergic cortical interneuron subtypes (parvalbumin, somatostatin, and 5-hydroxytryptamine receptor 3A) obtained from the Allen Human Brain Atlas. Acute alcohol administration increased local functional connectivity density within the visual cortex, sensorimotor cortex, thalamus, striatum, and cerebellum. Patterns of alcohol-induced changes in local functional connectivity density inversely correlated with somatostatin cortical gene expression. These findings suggest that somatostatin-expressing interneurons modulate alcohol-induced changes in functional connectivity in healthy individuals.
AB - Acute alcohol administration affects functional connectivity, yet the underlying mechanism is unknown. Previous work suggested that a moderate dose of alcohol reduces the activity of gamma-aminobutyric acidergic (GABAergic) interneurons, thereby leading to a state of pyramidal disinhibition and hyperexcitability. The present study aims to relate alcohol-induced changes in functional connectivity to regional genetic markers of GABAergic interneurons. Healthy young adults (N = 15, 5 males) underwent resting state functional MRI scanning prior to alcohol administration, immediately and 90 min after alcohol administration. Functional connectivity density mapping was performed to quantify alcohol-induced changes in resting brain activity between conditions. Patterns of differences between conditions were related to regional genetic markers that express the primary GABAergic cortical interneuron subtypes (parvalbumin, somatostatin, and 5-hydroxytryptamine receptor 3A) obtained from the Allen Human Brain Atlas. Acute alcohol administration increased local functional connectivity density within the visual cortex, sensorimotor cortex, thalamus, striatum, and cerebellum. Patterns of alcohol-induced changes in local functional connectivity density inversely correlated with somatostatin cortical gene expression. These findings suggest that somatostatin-expressing interneurons modulate alcohol-induced changes in functional connectivity in healthy individuals.
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U2 - 10.1038/s41598-022-12035-5
DO - 10.1038/s41598-022-12035-5
M3 - Article
C2 - 35550587
AN - SCOPUS:85129890293
SN - 2045-2322
VL - 12
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 7896
ER -
