Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report

Chie Watanabe; Jun Miyata; Kotoba Esaki; Ryohei Suematsu; Tomoya Sano; Takayuki Yamamoto; Hisashi Sasaki; Yohei Maki; Yoichi Tagami; Yoshifumi Kimizuka; Yuji Fujikura; Keiichi Ito; Akihiko Kawana

doi:10.1016/j.rmcr.2020.101112

Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report

Chie Watanabe, Jun Miyata, Kotoba Esaki, Ryohei Suematsu, Tomoya Sano, Takayuki Yamamoto, Hisashi Sasaki, Yohei Maki, Yoichi Tagami, Yoshifumi Kimizuka, Yuji Fujikura, Keiichi Ito, Akihiko Kawana

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1 Citation (Scopus)

Abstract

Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demonstrated intraluminal fibrotic changes in alveolar spaces. According to these findings, we diagnosed the patient with pazopanib-induced organizing pneumonia. To best of our knowledge, this is the first report of such a case.

Original language	English
Article number	101112
Journal	Respiratory Medicine Case Reports
Volume	30
DOIs	https://doi.org/10.1016/j.rmcr.2020.101112
Publication status	Published - 2020
Externally published	Yes

Keywords

Adverse event
Drug-induced lung injury
Leiomyosarcoma
Multityrosine kinase inhibitor
Organizing pneumoniae
Pazopanib

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.rmcr.2020.101112

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title = "Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report",

abstract = "Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demonstrated intraluminal fibrotic changes in alveolar spaces. According to these findings, we diagnosed the patient with pazopanib-induced organizing pneumonia. To best of our knowledge, this is the first report of such a case.",

keywords = "Adverse event, Drug-induced lung injury, Leiomyosarcoma, Multityrosine kinase inhibitor, Organizing pneumoniae, Pazopanib",

author = "Chie Watanabe and Jun Miyata and Kotoba Esaki and Ryohei Suematsu and Tomoya Sano and Takayuki Yamamoto and Hisashi Sasaki and Yohei Maki and Yoichi Tagami and Yoshifumi Kimizuka and Yuji Fujikura and Keiichi Ito and Akihiko Kawana",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

doi = "10.1016/j.rmcr.2020.101112",

language = "English",

volume = "30",

journal = "Respiratory Medicine Case Reports",

issn = "2213-0071",

publisher = "Elsevier BV",

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T1 - Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma

T2 - A case report

AU - Watanabe, Chie

AU - Miyata, Jun

AU - Esaki, Kotoba

AU - Suematsu, Ryohei

AU - Sano, Tomoya

AU - Yamamoto, Takayuki

AU - Sasaki, Hisashi

AU - Maki, Yohei

AU - Tagami, Yoichi

AU - Kimizuka, Yoshifumi

AU - Fujikura, Yuji

AU - Ito, Keiichi

AU - Kawana, Akihiko

PY - 2020

Y1 - 2020

N2 - Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demonstrated intraluminal fibrotic changes in alveolar spaces. According to these findings, we diagnosed the patient with pazopanib-induced organizing pneumonia. To best of our knowledge, this is the first report of such a case.

AB - Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demonstrated intraluminal fibrotic changes in alveolar spaces. According to these findings, we diagnosed the patient with pazopanib-induced organizing pneumonia. To best of our knowledge, this is the first report of such a case.

KW - Adverse event

KW - Drug-induced lung injury

KW - Leiomyosarcoma

KW - Multityrosine kinase inhibitor

KW - Organizing pneumoniae

KW - Pazopanib

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DO - 10.1016/j.rmcr.2020.101112

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JO - Respiratory Medicine Case Reports

JF - Respiratory Medicine Case Reports

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ER -

Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report

Abstract

Keywords

ASJC Scopus subject areas

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