PCNA and Ki-67 as prognostic markers in human parathyroid carcinomas

Kaori Kameyama, Hiroshi Takami, Shinobu Umemura, Yoshiyuki R. Osamura, Nobuyuki Wada, Kiminori Sugino, Takashi Mimura, Koichi Ito

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: It is widely accepted that histological diagnosis of parathyroid tumors is established with great difficulty. Carcinomas cannot be reliably separated from adenomas by histology alone. In this study, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) and Ki-67 was determined in 10 cases of parathyroid carcinomas, labeling indices (LIs) were calculated, and the results were correlated with the clinical outcomes. Methods: Ten cases of formalin-fixed, paraffin-embedded tissue with surgically resected parathyroid carcinoma were used. Immunohistochemical staining for PCNA and Ki-67 was performed and the LIs were calculated. We also examined whether LI could become a useful marker for parathyroid carcinomas. Results: Although nine patients with minimally invasive growth without recurrence of the tumor showed a low LI for both markers, one patient with a widely invasive neoplasm, and who died, had a high LI. Conclusions: These results suggested that the LI of PCNA and Ki-67, in addition to the histological appearance, may be markers of the biological behavior of parathyroid carcinomas. However, this study was on a small scale, so it may be valuable to repeat these studies in a larger group of patients with better defined histological criteria.

Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalAnnals of Surgical Oncology
Volume7
Issue number4
Publication statusPublished - 2000 May

Fingerprint

Parathyroid Neoplasms
Proliferating Cell Nuclear Antigen
Staining and Labeling
Neoplasms
Adenoma
Paraffin
Formaldehyde
Histology
Biomarkers
Carcinoma
Recurrence
Growth

Keywords

  • Ki-67
  • Labeling index
  • Parathyroid carcinoma
  • PCNA

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Kameyama, K., Takami, H., Umemura, S., Osamura, Y. R., Wada, N., Sugino, K., ... Ito, K. (2000). PCNA and Ki-67 as prognostic markers in human parathyroid carcinomas. Annals of Surgical Oncology, 7(4), 301-305.

PCNA and Ki-67 as prognostic markers in human parathyroid carcinomas. / Kameyama, Kaori; Takami, Hiroshi; Umemura, Shinobu; Osamura, Yoshiyuki R.; Wada, Nobuyuki; Sugino, Kiminori; Mimura, Takashi; Ito, Koichi.

In: Annals of Surgical Oncology, Vol. 7, No. 4, 05.2000, p. 301-305.

Research output: Contribution to journalArticle

Kameyama, K, Takami, H, Umemura, S, Osamura, YR, Wada, N, Sugino, K, Mimura, T & Ito, K 2000, 'PCNA and Ki-67 as prognostic markers in human parathyroid carcinomas', Annals of Surgical Oncology, vol. 7, no. 4, pp. 301-305.
Kameyama K, Takami H, Umemura S, Osamura YR, Wada N, Sugino K et al. PCNA and Ki-67 as prognostic markers in human parathyroid carcinomas. Annals of Surgical Oncology. 2000 May;7(4):301-305.
Kameyama, Kaori ; Takami, Hiroshi ; Umemura, Shinobu ; Osamura, Yoshiyuki R. ; Wada, Nobuyuki ; Sugino, Kiminori ; Mimura, Takashi ; Ito, Koichi. / PCNA and Ki-67 as prognostic markers in human parathyroid carcinomas. In: Annals of Surgical Oncology. 2000 ; Vol. 7, No. 4. pp. 301-305.
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