PDGFBB promotes PDGFRα-positive cell migration into artificial bone in vivo

Shigeyuki Yoshida, Ryotaro Iwasaki, Hiromasa Kawana, Yoshiteru Miyauchi, Hiroko Hoshi, Hiroya Miyamoto, Tomoaki Mori, Hiroya Kanagawa, Eri Katsuyama, Atsuhiro Fujie, Wu Hao, Tami Kobayashi, Yuiko Sato, Kana Miyamoto, Hideo Morioka, Morio Matsumoto, Kazuhiro Chiba, Yoshiaki Toyama, Taneaki Nakagawa, Takeshi Miyamoto

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Bone defects caused by traumatic bone loss or tumor dissection are now treated with auto- or allo-bone graft, and also occasionally by artificial bone transplantation, particularly in the case of large bone defects. However, artificial bones often exhibit poor affinity to host bones followed by bony union failure. Thus therapies combining artificial bones with growth factors have been sought. Here we report that platelet derived growth factor bb (PDGFBB) promotes a significant increase in migration of PDGF receptor α (PDGFRα)-positive mesenchymal stem cells/pre-osteoblastic cells into artificial bone . in vivo. Growth factors such as transforming growth factor beta (TGFβ) and hepatocyte growth factor (HGF) reportedly inhibit osteoblast differentiation; however, PDGFBB did not exhibit such inhibitory effects and in fact stimulated osteoblast differentiation . in vitro, suggesting that combining artificial bones with PDGFBB treatment could promote host cell migration into artificial bones without inhibiting osteoblastogenesis.

Original languageEnglish
Pages (from-to)785-789
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume421
Issue number4
DOIs
Publication statusPublished - 2012 May 18

Keywords

  • Artificial bone
  • Bone
  • Migration
  • Osteoblasts
  • PDGFBB

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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