PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker

Sayaka Yuzawa, Mitsunobu R. Kano, Takahiro Einama, Hiroshi Nishihara

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Pancreatic adenocarcinoma is a lethal disease that often develops a desmoplastic reaction in tumor stroma. In general, desmoplasia is thought to promote tumor growth. However, its molecular pathology and prognostic potential have not been fully investigated. Here, we investigate 26 cases of pancreatic ductal adenocarcinoma and examine the clinicopathological association between survival and expression levels of several molecular markers for stromal cells. These include alpha-smooth muscle actin (SMA) and platelet-derived growth factor (PDGF) receptor β (PDGFRβ). Both are markers of activated fibroblasts or pancreatic stellate cells (PSCs) that play an important role in desmoplasia. The staining patterns of both molecular markers were not uniform, so we categorized them into 3 grades (high, middle, and low) according to intensity. Interestingly, Kaplan-Meier analysis revealed that higher expression of PDGFRβ matched shorter prognosis (p = 0.0287, log-rank test) as well as lymphatic invasion and lymph node metastasis, whereas SMA did not (p = 0.6122). Our results suggest the prognostic potential of cancer stroma via PDGF-B signaling. Regulation of PDGF-B-associated signaling crosstalk between cancer cells and stroma cells, therefore, may indicate a possible therapeutic target for desmoplastic malignant tumors such as pancreatic adenocarcinoma.

Original languageEnglish
Pages (from-to)2824-2830
Number of pages7
JournalMedical Oncology
Volume29
Issue number4
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

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Platelet-Derived Growth Factor Receptors
Adenocarcinoma
Proto-Oncogene Proteins c-sis
Neoplasms
Smooth Muscle
Actins
Pancreatic Stellate Cells
Molecular Pathology
Kaplan-Meier Estimate
Stromal Cells
Fibroblasts
Lymph Nodes
Staining and Labeling
Neoplasm Metastasis
Growth

Keywords

  • Pancreatic adenocarcinoma
  • PDGFRβ
  • Prognosis
  • SMA
  • Tumor stroma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker. / Yuzawa, Sayaka; Kano, Mitsunobu R.; Einama, Takahiro; Nishihara, Hiroshi.

In: Medical Oncology, Vol. 29, No. 4, 01.12.2012, p. 2824-2830.

Research output: Contribution to journalArticle

Yuzawa, Sayaka ; Kano, Mitsunobu R. ; Einama, Takahiro ; Nishihara, Hiroshi. / PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker. In: Medical Oncology. 2012 ; Vol. 29, No. 4. pp. 2824-2830.
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