TY - JOUR
T1 - Pediatric community-acquired pneumonia treated with a three-day course of tebipenem pivoxil
AU - The World's First Oral Carbapenem Study Group
AU - Sakata, Hiroshi
AU - Kuroki, Haruo
AU - Ouchi, Kazunobu
AU - Tajima, Takeshi
AU - Iwata, Satoshi
N1 - Publisher Copyright:
© 2017 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
PY - 2017/5/1
Y1 - 2017/5/1
N2 - We evaluated the efficacy and safety of a 3-day treatment regimen of tebipenem pivoxil for pediatric community-acquired pneumonia. Tebipenem pivoxil was administered to 49 patients, and its effectiveness was evaluated in 36 patients 2–4 days after initiation of treatment. Thirty-two patients were cured 7–15 days after initiation of treatment. Body temperature was significantly lower on the day following initial administration (median 38.8 to 37.0 °C, n = 33). Leukocyte counts and C-reactive protein levels were significantly reduced by Day 2–4 of treatment (median 16,100 to 7800 white blood cells/μL, and 5.6 to 1.5 mg/dL, respectively; n = 28). Six of the 49 patients had mild diarrhea. Thus, we concluded that 3-day treatment with tebipenem pivoxil was safe and efficacious for treating pediatric community-acquired pneumonia.
AB - We evaluated the efficacy and safety of a 3-day treatment regimen of tebipenem pivoxil for pediatric community-acquired pneumonia. Tebipenem pivoxil was administered to 49 patients, and its effectiveness was evaluated in 36 patients 2–4 days after initiation of treatment. Thirty-two patients were cured 7–15 days after initiation of treatment. Body temperature was significantly lower on the day following initial administration (median 38.8 to 37.0 °C, n = 33). Leukocyte counts and C-reactive protein levels were significantly reduced by Day 2–4 of treatment (median 16,100 to 7800 white blood cells/μL, and 5.6 to 1.5 mg/dL, respectively; n = 28). Six of the 49 patients had mild diarrhea. Thus, we concluded that 3-day treatment with tebipenem pivoxil was safe and efficacious for treating pediatric community-acquired pneumonia.
KW - Community-acquired pneumonia
KW - Pediatric
KW - Tebipenem pivoxil
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U2 - 10.1016/j.jiac.2017.01.009
DO - 10.1016/j.jiac.2017.01.009
M3 - Article
AN - SCOPUS:85013644017
SN - 1341-321X
VL - 23
SP - 307
EP - 311
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
IS - 5
ER -
