Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord

Tomohiro Okuda, Nobuhiro Hata, Satoshi O. Suzuki, Koji Yoshimoto, Koichi Arimura, Takeo Amemiya, Yojiro Akagi, Daisuke Kuga, Utako Oba, Yuhki Koga, Shouichi Ohga, Toru Iwaki, Koji Iihara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The 2016 edition of the World Health Organization Classification of Tumors of the Central Nervous System introduced “diffuse midline glioma H3 K27M mutant” as a new diagnostic entity. These tumors predominately affect pediatric patients and arise from midline structures such as the brainstem, thalamus and spinal cord. Here, we report a rare patient with spinal ganglioglioma carrying an H3 K27M mutation. A 10-year-old boy presented with an intramedullary tumor in the cervical spinal cord. The lesion was partially removed and histologically diagnosed as ganglioglioma. After the remnant tumor grew within 3 months after surgery, the patient underwent radiotherapy. Genetic analyses revealed an H3F3A K27M mutation but no other genetic alterations such as IDH and BRAF mutations. This case may point to pathological heterogeneity in gliomas with H3 K27M mutations.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalNeuropathology
Volume38
Issue number4
DOIs
Publication statusPublished - 2018 Aug 1
Externally publishedYes

Fingerprint

Ganglioglioma
Pediatrics
Mutation
Glioma
Central Nervous System Neoplasms
Neoplasms
Thalamus
Brain Stem
Spinal Cord
Radiotherapy
Cervical Cord

Keywords

  • BRAF V600E
  • diffuse intrinsic pontine glioma
  • H3F3A
  • IDH, K27M

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Okuda, T., Hata, N., Suzuki, S. O., Yoshimoto, K., Arimura, K., Amemiya, T., ... Iihara, K. (2018). Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord. Neuropathology, 38(4), 422-427. https://doi.org/10.1111/neup.12471

Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord. / Okuda, Tomohiro; Hata, Nobuhiro; Suzuki, Satoshi O.; Yoshimoto, Koji; Arimura, Koichi; Amemiya, Takeo; Akagi, Yojiro; Kuga, Daisuke; Oba, Utako; Koga, Yuhki; Ohga, Shouichi; Iwaki, Toru; Iihara, Koji.

In: Neuropathology, Vol. 38, No. 4, 01.08.2018, p. 422-427.

Research output: Contribution to journalArticle

Okuda, T, Hata, N, Suzuki, SO, Yoshimoto, K, Arimura, K, Amemiya, T, Akagi, Y, Kuga, D, Oba, U, Koga, Y, Ohga, S, Iwaki, T & Iihara, K 2018, 'Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord', Neuropathology, vol. 38, no. 4, pp. 422-427. https://doi.org/10.1111/neup.12471
Okuda T, Hata N, Suzuki SO, Yoshimoto K, Arimura K, Amemiya T et al. Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord. Neuropathology. 2018 Aug 1;38(4):422-427. https://doi.org/10.1111/neup.12471
Okuda, Tomohiro ; Hata, Nobuhiro ; Suzuki, Satoshi O. ; Yoshimoto, Koji ; Arimura, Koichi ; Amemiya, Takeo ; Akagi, Yojiro ; Kuga, Daisuke ; Oba, Utako ; Koga, Yuhki ; Ohga, Shouichi ; Iwaki, Toru ; Iihara, Koji. / Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord. In: Neuropathology. 2018 ; Vol. 38, No. 4. pp. 422-427.
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