PEG-based nanocomposite hydrogel: Thermo-responsive sol-gel transition and degradation behavior controlled by the LA/GA ratio of PLGA-PEG-PLGA

Midori Kitagawa, Tomoki Maeda, Atsushi Hotta

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The sol-gel transition behavior and the degradation behavior of the nanocomposites consisting of laponite clay nanoparticles and poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers (laponite/PLGA-PEG-PLGA nanocomposites) were studied changing the LA/GA ratios of the PLGA blocks in the PLGA-PEG-PLGA. The thermo-responsive sol-gel transition at the physiological temperature (25–37 °C) was observed using the PLGA-PEG-PLGA with a high PEG/PLGA ratio of ∼0.8 regardless of the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). The decomposition rates of the laponite/PLGA-PEG-PLGA nanocomposites at 37 °C were regulated by adjusting the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). Specifically, ∼45% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratio of 1.1, while ∼30% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratios of 4.0 and 8.8.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalPolymer Degradation and Stability
Volume147
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Hydrogel
Hydrogels
Polyethylene glycols
Sol-gels
Nanocomposites
nanocomposites
gels
degradation
Degradation
decomposition
Decomposition
clays
glycols
copolymers
ethylene
adjusting
polyethylene glycol-poly(lactide-co-glycolide)
nanoparticles
laponite
Block copolymers

Keywords

  • Biodegradable
  • Nanocomposite
  • PLGA-PEG-PLGA
  • Thermo-responsive hydrogel

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanics of Materials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

@article{042fa61f456e401b879bb08cceef3372,
title = "PEG-based nanocomposite hydrogel: Thermo-responsive sol-gel transition and degradation behavior controlled by the LA/GA ratio of PLGA-PEG-PLGA",
abstract = "The sol-gel transition behavior and the degradation behavior of the nanocomposites consisting of laponite clay nanoparticles and poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers (laponite/PLGA-PEG-PLGA nanocomposites) were studied changing the LA/GA ratios of the PLGA blocks in the PLGA-PEG-PLGA. The thermo-responsive sol-gel transition at the physiological temperature (25–37 °C) was observed using the PLGA-PEG-PLGA with a high PEG/PLGA ratio of ∼0.8 regardless of the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). The decomposition rates of the laponite/PLGA-PEG-PLGA nanocomposites at 37 °C were regulated by adjusting the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). Specifically, ∼45{\%} of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratio of 1.1, while ∼30{\%} of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratios of 4.0 and 8.8.",
keywords = "Biodegradable, Nanocomposite, PLGA-PEG-PLGA, Thermo-responsive hydrogel",
author = "Midori Kitagawa and Tomoki Maeda and Atsushi Hotta",
year = "2018",
month = "1",
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doi = "10.1016/j.polymdegradstab.2017.11.024",
language = "English",
volume = "147",
pages = "222--228",
journal = "Polymer Degradation and Stability",
issn = "0141-3910",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - PEG-based nanocomposite hydrogel

T2 - Thermo-responsive sol-gel transition and degradation behavior controlled by the LA/GA ratio of PLGA-PEG-PLGA

AU - Kitagawa, Midori

AU - Maeda, Tomoki

AU - Hotta, Atsushi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The sol-gel transition behavior and the degradation behavior of the nanocomposites consisting of laponite clay nanoparticles and poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers (laponite/PLGA-PEG-PLGA nanocomposites) were studied changing the LA/GA ratios of the PLGA blocks in the PLGA-PEG-PLGA. The thermo-responsive sol-gel transition at the physiological temperature (25–37 °C) was observed using the PLGA-PEG-PLGA with a high PEG/PLGA ratio of ∼0.8 regardless of the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). The decomposition rates of the laponite/PLGA-PEG-PLGA nanocomposites at 37 °C were regulated by adjusting the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). Specifically, ∼45% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratio of 1.1, while ∼30% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratios of 4.0 and 8.8.

AB - The sol-gel transition behavior and the degradation behavior of the nanocomposites consisting of laponite clay nanoparticles and poly(D,L-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers (laponite/PLGA-PEG-PLGA nanocomposites) were studied changing the LA/GA ratios of the PLGA blocks in the PLGA-PEG-PLGA. The thermo-responsive sol-gel transition at the physiological temperature (25–37 °C) was observed using the PLGA-PEG-PLGA with a high PEG/PLGA ratio of ∼0.8 regardless of the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). The decomposition rates of the laponite/PLGA-PEG-PLGA nanocomposites at 37 °C were regulated by adjusting the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). Specifically, ∼45% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratio of 1.1, while ∼30% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratios of 4.0 and 8.8.

KW - Biodegradable

KW - Nanocomposite

KW - PLGA-PEG-PLGA

KW - Thermo-responsive hydrogel

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U2 - 10.1016/j.polymdegradstab.2017.11.024

DO - 10.1016/j.polymdegradstab.2017.11.024

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JO - Polymer Degradation and Stability

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