Pemphigoid nodularis with IgA autoantibodies against the intracellular domain of desmoglein 1

Hiroshi Fujisawa, Y. Ishii, T. Tateishi, Y. Kawachi, F. Otsuka, Masayuki Amagai, A. Komai, T. Hashimoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Pemphigoid nodularis is a rare variant of bullous pemphigoid. We report a 49-year-old Japanese male with clinical and histopathological features of pemphigoid nodularis including circulating and in vivo-bound IgG antibasement membrane zone antibodies and IgA anti-intercellular antibodies. Although the precise molecular target of the IgG autoantibodies could not be determined, intriguingly, immunoblotting showed that the IgA in the patient's serum reacted with the intracellular domain of desmoglein 1, the target antigen in cases of pemphigus foliaceus. However, the IgA did not react with the extracellular domain of desmoglein 1 in sensitive enzyme-linked immunosorbent assay studies using a baculovirus system. These results suggest therefore that these IgA antibodies may possibly not be pathogenic. The mechanism for the production of different autoantibodies is unknown, but this case provides further illustration of the atypical skin immunoreactants often seen in this unusual subtype of bullous pemphigoid.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalBritish Journal of Dermatology
Volume142
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Desmoglein 1
Bullous Pemphigoid
Autoantibodies
Immunoglobulin A
Immunoglobulin G
Pemphigus
Antibodies
Baculoviridae
Immunoblotting
Anti-Idiotypic Antibodies
Enzyme-Linked Immunosorbent Assay
Antigens
Skin
Membranes
Serum

Keywords

  • Desmoglein 1
  • IgA autoantibody
  • Pemphigoid nodularis

ASJC Scopus subject areas

  • Dermatology

Cite this

Pemphigoid nodularis with IgA autoantibodies against the intracellular domain of desmoglein 1. / Fujisawa, Hiroshi; Ishii, Y.; Tateishi, T.; Kawachi, Y.; Otsuka, F.; Amagai, Masayuki; Komai, A.; Hashimoto, T.

In: British Journal of Dermatology, Vol. 142, No. 1, 2000, p. 143-147.

Research output: Contribution to journalArticle

Fujisawa, H, Ishii, Y, Tateishi, T, Kawachi, Y, Otsuka, F, Amagai, M, Komai, A & Hashimoto, T 2000, 'Pemphigoid nodularis with IgA autoantibodies against the intracellular domain of desmoglein 1', British Journal of Dermatology, vol. 142, no. 1, pp. 143-147. https://doi.org/10.1046/j.1365-2133.2000.03257.x
Fujisawa, Hiroshi ; Ishii, Y. ; Tateishi, T. ; Kawachi, Y. ; Otsuka, F. ; Amagai, Masayuki ; Komai, A. ; Hashimoto, T. / Pemphigoid nodularis with IgA autoantibodies against the intracellular domain of desmoglein 1. In: British Journal of Dermatology. 2000 ; Vol. 142, No. 1. pp. 143-147.
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AU - Tateishi, T.

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AU - Otsuka, F.

AU - Amagai, Masayuki

AU - Komai, A.

AU - Hashimoto, T.

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AB - Pemphigoid nodularis is a rare variant of bullous pemphigoid. We report a 49-year-old Japanese male with clinical and histopathological features of pemphigoid nodularis including circulating and in vivo-bound IgG antibasement membrane zone antibodies and IgA anti-intercellular antibodies. Although the precise molecular target of the IgG autoantibodies could not be determined, intriguingly, immunoblotting showed that the IgA in the patient's serum reacted with the intracellular domain of desmoglein 1, the target antigen in cases of pemphigus foliaceus. However, the IgA did not react with the extracellular domain of desmoglein 1 in sensitive enzyme-linked immunosorbent assay studies using a baculovirus system. These results suggest therefore that these IgA antibodies may possibly not be pathogenic. The mechanism for the production of different autoantibodies is unknown, but this case provides further illustration of the atypical skin immunoreactants often seen in this unusual subtype of bullous pemphigoid.

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