Pemphigus

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pemphigus is a group of autoimmune bullous diseases of the skin and mucous membranes, which are characterized by IgG autoantibodies against desmogelin 3 (Dsg3) and/or Dsg1. Recent molecular biology techniques such as the phage display system allowed us to isolate monoclonal antibodies from peripheral blood of patients with pemphigus and to characterize their pathogenic activities and their epitopes on desmogleins. Through these studies, hot epitopes as well as a characteristic consensus sequence of CDR3 regions of pathogenic antibodies were identified. Concurrently, an active disease mouse model of pemphigus was developed by adoptive transfer of peripheral lymphocytes from Dsg3 -/- mice. Dsg3-specific CD4+ T cells were isolated from pemphigus model mice and, subsequently, Dsg3-specific T cell receptor (TCR) transgenic mice were generated. These studies have revealed that Dsg3-specific CD4+ T cells were able to induce, notn only antibody production with B cells and acantholysis, but also interface dermatitis. These studies have provided better understanding of pathophysiological mechanisms for pemphigus as well as deep insights for T-cell-mediated inflammatory skin diseases.

Original languageEnglish
Title of host publicationImmunology of the Skin
Subtitle of host publicationBasic and Clinical Sciences in Skin Immune Responses
PublisherSpringer Japan
Pages405-417
Number of pages13
ISBN (Electronic)9784431558552
ISBN (Print)9784431558538
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

T-cells
Epitopes
Antibodies
Skin
Dermatitis
Molecular biology
Bacteriophages
Monoclonal antibodies
Lymphocytes
Blood
Display devices
Cells

Keywords

  • Autoantibodies
  • Autoimmunity
  • Autoreactive T cells
  • Desmoglein
  • Mouse model
  • Pemphigus
  • Tolerance

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Yamagami, J., Takahashi, H., & Amagai, M. (2016). Pemphigus. In Immunology of the Skin: Basic and Clinical Sciences in Skin Immune Responses (pp. 405-417). Springer Japan. https://doi.org/10.1007/978-4-431-55855-2_25

Pemphigus. / Yamagami, Jun; Takahashi, Hayato; Amagai, Masayuki.

Immunology of the Skin: Basic and Clinical Sciences in Skin Immune Responses. Springer Japan, 2016. p. 405-417.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yamagami, J, Takahashi, H & Amagai, M 2016, Pemphigus. in Immunology of the Skin: Basic and Clinical Sciences in Skin Immune Responses. Springer Japan, pp. 405-417. https://doi.org/10.1007/978-4-431-55855-2_25
Yamagami J, Takahashi H, Amagai M. Pemphigus. In Immunology of the Skin: Basic and Clinical Sciences in Skin Immune Responses. Springer Japan. 2016. p. 405-417 https://doi.org/10.1007/978-4-431-55855-2_25
Yamagami, Jun ; Takahashi, Hayato ; Amagai, Masayuki. / Pemphigus. Immunology of the Skin: Basic and Clinical Sciences in Skin Immune Responses. Springer Japan, 2016. pp. 405-417
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