Abstract
The immunopathological mechanism of pemphigus foliaceus acantholysis remains controversial. Previous workers have found that IgG autoantibodies are reactive with the epidermal surface and capable of blister induction. The presence of complement components in lesions also suggests their potential role in this disease. Complement participation, however, has not been clearly demonstrated. We describe a case of pemphigus foliaceus (PF) in a 58-year old woman which was confirmed by histopathological and immunopathological studies, and by ELISA assay on recombinant PF antigen. Unusual features of this case include the predominance of IgG1 anti-epithelial antibody in both the deposits and circulation, and the preferential binding of IgG and complement component 3 at the upper epidermis. We believe that this pattern of co-localized deposition suggests a location-specific, non-random complement activation.
| Original language | English |
|---|---|
| Pages (from-to) | 249-252 |
| Number of pages | 4 |
| Journal | British Journal of Dermatology |
| Volume | 136 |
| Issue number | 2 |
| Publication status | Published - 1997 |
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ASJC Scopus subject areas
- Dermatology
Cite this
Pemphigus foliaceus : Preferential binding of IgG1 and C3 at the upper epidermis. / Hernandez, C.; Amagai, Masayuki; Chan, L. S.
In: British Journal of Dermatology, Vol. 136, No. 2, 1997, p. 249-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pemphigus foliaceus
T2 - Preferential binding of IgG1 and C3 at the upper epidermis
AU - Hernandez, C.
AU - Amagai, Masayuki
AU - Chan, L. S.
PY - 1997
Y1 - 1997
N2 - The immunopathological mechanism of pemphigus foliaceus acantholysis remains controversial. Previous workers have found that IgG autoantibodies are reactive with the epidermal surface and capable of blister induction. The presence of complement components in lesions also suggests their potential role in this disease. Complement participation, however, has not been clearly demonstrated. We describe a case of pemphigus foliaceus (PF) in a 58-year old woman which was confirmed by histopathological and immunopathological studies, and by ELISA assay on recombinant PF antigen. Unusual features of this case include the predominance of IgG1 anti-epithelial antibody in both the deposits and circulation, and the preferential binding of IgG and complement component 3 at the upper epidermis. We believe that this pattern of co-localized deposition suggests a location-specific, non-random complement activation.
AB - The immunopathological mechanism of pemphigus foliaceus acantholysis remains controversial. Previous workers have found that IgG autoantibodies are reactive with the epidermal surface and capable of blister induction. The presence of complement components in lesions also suggests their potential role in this disease. Complement participation, however, has not been clearly demonstrated. We describe a case of pemphigus foliaceus (PF) in a 58-year old woman which was confirmed by histopathological and immunopathological studies, and by ELISA assay on recombinant PF antigen. Unusual features of this case include the predominance of IgG1 anti-epithelial antibody in both the deposits and circulation, and the preferential binding of IgG and complement component 3 at the upper epidermis. We believe that this pattern of co-localized deposition suggests a location-specific, non-random complement activation.
UR - http://www.scopus.com/inward/record.url?scp=0031053915&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031053915&partnerID=8YFLogxK
M3 - Article
VL - 136
SP - 249
EP - 252
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 2
ER -