Peptide Toxins Targeting KV Channels

Kazuki Matsumura, Mariko Yokogawa, Masanori Osawa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A number of peptide toxins isolated from animals target potassium ion (K+) channels. Many of them are particularly known to inhibit voltage-gated K+ (KV) channels and are mainly classified into pore-blocking toxins or gating-modifier toxins. Pore-blocking toxins directly bind to the ion permeation pores of KV channels, thereby physically occluding them. In contrast, gating-modifier toxins bind to the voltage-sensor domains of KV channels, modulating their voltage-dependent conformational changes. These peptide toxins are useful molecular tools in revealing the structure-function relationship of KV channels and have potential for novel treatments for diseases related to KV channels. This review focuses on the inhibition mechanism of pore-blocking and gating-modifier toxins that target KV channels.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer Science and Business Media Deutschland GmbH
Pages481-505
Number of pages25
DOIs
Publication statusPublished - 2021

Publication series

NameHandbook of Experimental Pharmacology
Volume267
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Gating-modifier toxin
  • Peptide toxin
  • Pore-blocking toxin
  • Voltage-gated potassium channel

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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