Peptides bound to stereoregular PMMAs

Toshiki Sawada, Hisao Matsuno, Teruhiko Matsubara, Toshinori Sato, Tatsuki Kitayama, Takeshi Serizawa

Research output: Contribution to conferencePaper

Abstract

To identify peptides with selective affinity for stereoregular isotactic poly(methyl methacrylate) (it-PMMA), the phage display selection using a heptamer random peptide library was carried out. After five rounds of biopanning, several phage clones with high specific affinity to it-PMMA were selected. As a result of DNA sequencing, nine kinds of it-PMMA binding phage clones were isolated. The binding affinity and specificity of these phage clones were quantitatively investigated by an enzyme-linked immunosorbent assay. These clones not only bound to it-PMMA greater than a phage library, but showed the specific binding to it-PMMA rather than syndiotactic and atactic PMMAs.

Original languageEnglish
Pages4867-4868
Number of pages2
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sep 202005 Sep 22

Other

Other54th SPSJ Symposium on Macromolecules
CountryJapan
CityYamagata
Period05/9/2005/9/22

Keywords

  • Peptide
  • Phage display
  • Poly(methyl methacrylate)
  • Tacticity

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Sawada, T., Matsuno, H., Matsubara, T., Sato, T., Kitayama, T., & Serizawa, T. (2005). Peptides bound to stereoregular PMMAs. 4867-4868. Paper presented at 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.