Peptidoglycan as Nod1 ligand; Fragment structures in the environment, chemical synthesis, and their innate immunostimulation

Yukari Fujimoto, Ambara Rachmat Pradipta, Naohiro Inohara, Koichi Fukase

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

This review focuses on the recent revealing of the immunostimulatory bacterial cell wall peptidoglycan (PGN) fragments as Nod1 ligands, especially a newly developed chemical synthesis of the partial structures, fragment structures in the environment and bacterial supernatant, and the immunostimulatory activities of the Nod1 ligands.

Original languageEnglish
Pages (from-to)568-579
Number of pages12
JournalNatural Product Reports
Volume29
Issue number5
DOIs
Publication statusPublished - 2012 May 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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