Peptidoglycan as Nod1 ligand; Fragment structures in the environment, chemical synthesis, and their innate immunostimulation

Yukari Fujimoto, Ambara Rachmat Pradipta, Naohiro Inohara, Koichi Fukase

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This review focuses on the recent revealing of the immunostimulatory bacterial cell wall peptidoglycan (PGN) fragments as Nod1 ligands, especially a newly developed chemical synthesis of the partial structures, fragment structures in the environment and bacterial supernatant, and the immunostimulatory activities of the Nod1 ligands.

Original languageEnglish
Pages (from-to)568-579
Number of pages12
JournalNatural Product Reports
Volume29
Issue number5
DOIs
Publication statusPublished - 2012 May
Externally publishedYes

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Peptidoglycan
Immunization
Ligands
Cell Wall
Cells

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Peptidoglycan as Nod1 ligand; Fragment structures in the environment, chemical synthesis, and their innate immunostimulation. / Fujimoto, Yukari; Pradipta, Ambara Rachmat; Inohara, Naohiro; Fukase, Koichi.

In: Natural Product Reports, Vol. 29, No. 5, 05.2012, p. 568-579.

Research output: Contribution to journalArticle

Fujimoto, Yukari ; Pradipta, Ambara Rachmat ; Inohara, Naohiro ; Fukase, Koichi. / Peptidoglycan as Nod1 ligand; Fragment structures in the environment, chemical synthesis, and their innate immunostimulation. In: Natural Product Reports. 2012 ; Vol. 29, No. 5. pp. 568-579.
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