Percutaneous cryoablation of pulmonary metastases from colorectal cancer

Yoshikane Yamauchi, Yotaro Izumi, Masafumi Kawamura, Seishi Nakatsuka, Hideki Yashiro, Norimasa Tsukada, Masanori Inoue, Keisuke Asakura, Hiroaki Nomori

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: To evaluate the safety and efficacy of cryoablation for metastatic lung tumors from colorectal cancer. Methods: The procedures were performed on 24 patients (36-82 years of age, with a median age of 62; 17 male patients, 7 female patients) for 55 metastatic tumors in the lung, during 30 sessions. The procedural safety, local progression free interval, and overall survival were assessed by follow-up computed tomographic scanning performed every 3-4 months. Results: The major complications were pneumothorax, 19 sessions (63%), pleural effusion, 21 sessions (70%), transient and self-limiting hemoptysis, 13 sessions (43%) and tract seeding, 1 session (3%). The 1- and 3-year local progression free intervals were 90.8% and 59%, respectively. The 3-years local progression free intervals of tumors ≤15 mm in diameter was 79.8% and that of tumors >15 mm was 28.6% (p = 0.001; log-rank test). The 1- and 3-year overall survival rates were 91% and 59.6%, respectively. Conclusion: The results indicated that percutaneous cryoablation is a feasible treatment option. The local progression free interval was satisfactory at least for tumors that were ≤15 mm in diameter.

Original languageEnglish
Article numbere27086
JournalPLoS One
Volume6
Issue number11
DOIs
Publication statusPublished - 2011 Nov 9

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Cryosurgery
colorectal neoplasms
metastasis
Tumors
Colorectal Neoplasms
lungs
lung neoplasms
Neoplasm Metastasis
Lung
neoplasms
pneumothorax
Neoplasms
Safety
sowing
survival rate
Hemoptysis
Pneumothorax
Pleural Effusion
Survival Rate
Scanning

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Yamauchi, Y., Izumi, Y., Kawamura, M., Nakatsuka, S., Yashiro, H., Tsukada, N., ... Nomori, H. (2011). Percutaneous cryoablation of pulmonary metastases from colorectal cancer. PLoS One, 6(11), [e27086]. https://doi.org/10.1371/journal.pone.0027086

Percutaneous cryoablation of pulmonary metastases from colorectal cancer. / Yamauchi, Yoshikane; Izumi, Yotaro; Kawamura, Masafumi; Nakatsuka, Seishi; Yashiro, Hideki; Tsukada, Norimasa; Inoue, Masanori; Asakura, Keisuke; Nomori, Hiroaki.

In: PLoS One, Vol. 6, No. 11, e27086, 09.11.2011.

Research output: Contribution to journalArticle

Yamauchi, Y, Izumi, Y, Kawamura, M, Nakatsuka, S, Yashiro, H, Tsukada, N, Inoue, M, Asakura, K & Nomori, H 2011, 'Percutaneous cryoablation of pulmonary metastases from colorectal cancer', PLoS One, vol. 6, no. 11, e27086. https://doi.org/10.1371/journal.pone.0027086
Yamauchi, Yoshikane ; Izumi, Yotaro ; Kawamura, Masafumi ; Nakatsuka, Seishi ; Yashiro, Hideki ; Tsukada, Norimasa ; Inoue, Masanori ; Asakura, Keisuke ; Nomori, Hiroaki. / Percutaneous cryoablation of pulmonary metastases from colorectal cancer. In: PLoS One. 2011 ; Vol. 6, No. 11.
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