Performance of Gd-EOB-DTPA and superparamagnetic iron oxide particles in the detection of primary liver cancer: A comparative study by alternative free-response receiver operating characteristic analysis

Akihiro Tanimoto, Yoshinori Satoh, Yuji Yuasa, Masahiro Jinzaki, Kyoichi Hiramatsu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The performance of gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) and superparamagnetic iron oxide (SPIO) particles in detecting liver cancer was compared using alternative free-response receiver operating characteristic (AFROC) analysis, which allowed observers to indicate both the confidence level and the locations of all perceived abnormalities. Axial T1-weighted MR images (1.5 T) pre/post Gd-EOB-DTPA (25 μmol/kg) injection were obtained for 12 rats with chemically induced liver tumors (64 tumors). T2-weighted images (T2WI) were obtained pre/post SPIO (10 μmol/kg) injection for the same animal. Liver signal-to-noise ratio (SNR), tumor-liver contrast-to-noise ratio (CNR), and histopathologic sections corresponding to MR images were obtained. In AFROC, the location and the confidence level for each tumor were indicated independently on MR images by four radiologists. By plotting true-positive fraction and probability of false-positive per image, the area under the AFROC curve (A1) was estimated and statistically analyzed between each sequence. Either drug significantly improved tumor-liver CNR (P < .001) and tumor detection (diameter ≤ 6 mm; P < .05). Gd-EOB-DTPA significantly (P < .05) improved the A1 in T1WI. There was no Ai difference between T2WI + SPIO and T1WI + Gd-EOB-DTPA. Gd-EOB-DTPA-enhanced T1WI showed the same performance as SPIO-enhanced T2WI in detecting liver tumors.

Original languageEnglish
Pages (from-to)120-124
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume7
Issue number1
DOIs
Publication statusPublished - 1997 Jan 1

Keywords

  • Contrast media, gadolinium, iron, magnetic resonance
  • Diagnosis, magnetic resonance
  • Experimental, liver
  • Magnetic resonance
  • Neoplasm

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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