TY - JOUR
T1 - Periductal infiltrating type of intrahepatic cholangiocarcinoma
T2 - A rare macroscopic type without any apparent mass
AU - Uno, Masanori
AU - Shimada, Kazuaki
AU - Yamamoto, Yusuke
AU - Nara, Satoshi
AU - Esaki, Minoru
AU - Sakamoto, Yoshihiro
AU - Kosuge, Tomoo
AU - Ojima, Hidenori
N1 - Funding Information:
This study was supported by a Grant-in-Aid for cancer research from the Ministry of Health, Welfare and Labor of Japan (21-7-5). Masanori Uno and co-authors have no direct or indirect commercial and financial incentive associated with publishing the article.
PY - 2012/12
Y1 - 2012/12
N2 - Purpose: This study was undertaken to elucidate the clinicopathological characteristics and surgical outcome of the periductal infiltrating (PI) type of intrahepatic cholangiocarcinoma (ICC), which is a distinct macroscopic type of ICC arising from the second-order of the intrahepatic bile ducts without apparent invasion of the surrounding liver parenchyma. Methods: All patients with the PI type of ICC were identified from a database of patients with intrahepatic cholangiocellular carcinoma that underwent surgical resection between 1983 and 2009. The clinicopathological data of these patients were analyzed retrospectively. Results: Sixteen of 203 patients (7.9%) had the PI type of ICC. The median survival was 7.7 years with 5-year survival rate of 62.1%. The PI type of ICC showed a significantly better survival than the mass-forming (MF) type (P = 0.0293) or MF plus PI type of ICC (P = 0.0001). Microscopic examinations showed intrahepatic metastasis to be absent in all the patients with PI type ICC. The incidence of intrahepatic metastases in patients with PI type was significantly lower in comparison to that of patients with MF type (P = 0.0030) and MF plus PI type (P = 0.0533), respectively. Conclusion: Surgery could therefore provide a favorable outcome in patients with the PI type of ICC, probably due to its lower incidence of intrahepatic metastases.
AB - Purpose: This study was undertaken to elucidate the clinicopathological characteristics and surgical outcome of the periductal infiltrating (PI) type of intrahepatic cholangiocarcinoma (ICC), which is a distinct macroscopic type of ICC arising from the second-order of the intrahepatic bile ducts without apparent invasion of the surrounding liver parenchyma. Methods: All patients with the PI type of ICC were identified from a database of patients with intrahepatic cholangiocellular carcinoma that underwent surgical resection between 1983 and 2009. The clinicopathological data of these patients were analyzed retrospectively. Results: Sixteen of 203 patients (7.9%) had the PI type of ICC. The median survival was 7.7 years with 5-year survival rate of 62.1%. The PI type of ICC showed a significantly better survival than the mass-forming (MF) type (P = 0.0293) or MF plus PI type of ICC (P = 0.0001). Microscopic examinations showed intrahepatic metastasis to be absent in all the patients with PI type ICC. The incidence of intrahepatic metastases in patients with PI type was significantly lower in comparison to that of patients with MF type (P = 0.0030) and MF plus PI type (P = 0.0533), respectively. Conclusion: Surgery could therefore provide a favorable outcome in patients with the PI type of ICC, probably due to its lower incidence of intrahepatic metastases.
KW - Intrahepatic cholangiocarcinoma
KW - Macroscopic classification
KW - Mass-forming plus periductal infiltrating type
KW - Periductal infiltrating type
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U2 - 10.1007/s00595-012-0145-5
DO - 10.1007/s00595-012-0145-5
M3 - Article
C2 - 22350300
AN - SCOPUS:84877293739
SN - 0941-1291
VL - 42
SP - 1189
EP - 1194
JO - Surgery Today
JF - Surgery Today
IS - 12
ER -