Periductal infiltrating type of intrahepatic cholangiocarcinoma: A rare macroscopic type without any apparent mass

Masanori Uno, Kazuaki Shimada, Yusuke Yamamoto, Satoshi Nara, Minoru Esaki, Yoshihiro Sakamoto, Tomoo Kosuge, Hidenori Ojima

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: This study was undertaken to elucidate the clinicopathological characteristics and surgical outcome of the periductal infiltrating (PI) type of intrahepatic cholangiocarcinoma (ICC), which is a distinct macroscopic type of ICC arising from the second-order of the intrahepatic bile ducts without apparent invasion of the surrounding liver parenchyma. Methods: All patients with the PI type of ICC were identified from a database of patients with intrahepatic cholangiocellular carcinoma that underwent surgical resection between 1983 and 2009. The clinicopathological data of these patients were analyzed retrospectively. Results: Sixteen of 203 patients (7.9%) had the PI type of ICC. The median survival was 7.7 years with 5-year survival rate of 62.1%. The PI type of ICC showed a significantly better survival than the mass-forming (MF) type (P = 0.0293) or MF plus PI type of ICC (P = 0.0001). Microscopic examinations showed intrahepatic metastasis to be absent in all the patients with PI type ICC. The incidence of intrahepatic metastases in patients with PI type was significantly lower in comparison to that of patients with MF type (P = 0.0030) and MF plus PI type (P = 0.0533), respectively. Conclusion: Surgery could therefore provide a favorable outcome in patients with the PI type of ICC, probably due to its lower incidence of intrahepatic metastases.

Original languageEnglish
Pages (from-to)1189-1194
Number of pages6
JournalSurgery Today
Volume42
Issue number12
DOIs
Publication statusPublished - 2012 Dec
Externally publishedYes

Fingerprint

Cholangiocarcinoma
Neoplasm Metastasis
Intrahepatic Bile Ducts
Survival
Incidence
Survival Rate
Databases
Liver

Keywords

  • Intrahepatic cholangiocarcinoma
  • Macroscopic classification
  • Mass-forming plus periductal infiltrating type
  • Periductal infiltrating type

ASJC Scopus subject areas

  • Surgery

Cite this

Periductal infiltrating type of intrahepatic cholangiocarcinoma : A rare macroscopic type without any apparent mass. / Uno, Masanori; Shimada, Kazuaki; Yamamoto, Yusuke; Nara, Satoshi; Esaki, Minoru; Sakamoto, Yoshihiro; Kosuge, Tomoo; Ojima, Hidenori.

In: Surgery Today, Vol. 42, No. 12, 12.2012, p. 1189-1194.

Research output: Contribution to journalArticle

Uno, Masanori ; Shimada, Kazuaki ; Yamamoto, Yusuke ; Nara, Satoshi ; Esaki, Minoru ; Sakamoto, Yoshihiro ; Kosuge, Tomoo ; Ojima, Hidenori. / Periductal infiltrating type of intrahepatic cholangiocarcinoma : A rare macroscopic type without any apparent mass. In: Surgery Today. 2012 ; Vol. 42, No. 12. pp. 1189-1194.
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abstract = "Purpose: This study was undertaken to elucidate the clinicopathological characteristics and surgical outcome of the periductal infiltrating (PI) type of intrahepatic cholangiocarcinoma (ICC), which is a distinct macroscopic type of ICC arising from the second-order of the intrahepatic bile ducts without apparent invasion of the surrounding liver parenchyma. Methods: All patients with the PI type of ICC were identified from a database of patients with intrahepatic cholangiocellular carcinoma that underwent surgical resection between 1983 and 2009. The clinicopathological data of these patients were analyzed retrospectively. Results: Sixteen of 203 patients (7.9{\%}) had the PI type of ICC. The median survival was 7.7 years with 5-year survival rate of 62.1{\%}. The PI type of ICC showed a significantly better survival than the mass-forming (MF) type (P = 0.0293) or MF plus PI type of ICC (P = 0.0001). Microscopic examinations showed intrahepatic metastasis to be absent in all the patients with PI type ICC. The incidence of intrahepatic metastases in patients with PI type was significantly lower in comparison to that of patients with MF type (P = 0.0030) and MF plus PI type (P = 0.0533), respectively. Conclusion: Surgery could therefore provide a favorable outcome in patients with the PI type of ICC, probably due to its lower incidence of intrahepatic metastases.",
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