Perinatal outcomes: Intravenous patient-controlled fentanyl versus no analgesia in labor

Kei Miyakoshi, Mamoru Tanaka, Hiroshi Morisaki, Seon Hye Kim, Yuki Hosokawa, Tadashi Matsumoto, Kazuhiro Minegishi, Yasunori Yoshimura

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: To investigate perinatal outcomes, the analgesic efficacy and maternal satisfaction in nulliparous women receiving fentanyl intravenous patient-controlled analgesia (i.v.-PCA). Material and Methods: A total of 1401 nulliparous women with a singleton pregnancy who received fentanyl i.v.-PCA (i.v.-PCA group, n = 290) or no analgesia (control group, n = 1111) in labor between 2005 and 2010 were reviewed. Fentanyl i.v.-PCA was implemented on maternal request during the first stage of labor over 35 weeks of gestation, and discontinued at full cervical dilatation. Perinatal outcomes were compared between the i.v.-PCA and the control groups. The numerical rating scale (NRS) levels during labor were also examined in the i.v.-PCA group. Additionally, parturients received fentanyl i.v.-PCA in 2010 (n = 73) were asked about overall satisfaction using a scale poor, moderate, good and excellent on postpartum day 0-3. Results: Women receiving i.v.-PCA showed significantly longer labor and more need of oxytocin augmentation, compared with the control. Cesarean section was significantly less frequent in the i.v.-PCA group compared with the control (11.0% v.s. 24.1%, respectively), with the vacuum-assisted delivery rate comparable between groups. Neonatal outcomes (i.e. Apgar score <7 at 1 min or 5 min, umbilical artery pH <7.20) were comparable between groups, irrespective of mode of delivery. Significant reduction of NRS levels was noted until 3 h after induction of i.v.-PCA, compared to the baseline. Of the women who expressed their satisfaction, 72% (48/67) exhibited 'excellent' or 'good' for pain relief by i.v.-PCA. Conclusion: Fentanyl i.v.-PCA could be a useful approach for labor pain relief in nulliparas when regional blocks are unavailable.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalJournal of Obstetrics and Gynaecology Research
Volume39
Issue number4
DOIs
Publication statusPublished - 2013 Apr

Fingerprint

Patient-Controlled Analgesia
Fentanyl
Analgesia
First Labor Stage
Mothers
Labor Pain
Pregnancy
Control Groups
Umbilical Arteries
Apgar Score
Oxytocin
Vacuum
Cesarean Section
Postpartum Period
Analgesics

Keywords

  • Cesarean section
  • Fentanyl
  • Intravenous patient-controlled analgesia
  • Labor pain relief
  • Prolonged labor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Perinatal outcomes : Intravenous patient-controlled fentanyl versus no analgesia in labor. / Miyakoshi, Kei; Tanaka, Mamoru; Morisaki, Hiroshi; Kim, Seon Hye; Hosokawa, Yuki; Matsumoto, Tadashi; Minegishi, Kazuhiro; Yoshimura, Yasunori.

In: Journal of Obstetrics and Gynaecology Research, Vol. 39, No. 4, 04.2013, p. 783-789.

Research output: Contribution to journalArticle

Miyakoshi, Kei ; Tanaka, Mamoru ; Morisaki, Hiroshi ; Kim, Seon Hye ; Hosokawa, Yuki ; Matsumoto, Tadashi ; Minegishi, Kazuhiro ; Yoshimura, Yasunori. / Perinatal outcomes : Intravenous patient-controlled fentanyl versus no analgesia in labor. In: Journal of Obstetrics and Gynaecology Research. 2013 ; Vol. 39, No. 4. pp. 783-789.
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AU - Hosokawa, Yuki

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AU - Minegishi, Kazuhiro

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N2 - Aim: To investigate perinatal outcomes, the analgesic efficacy and maternal satisfaction in nulliparous women receiving fentanyl intravenous patient-controlled analgesia (i.v.-PCA). Material and Methods: A total of 1401 nulliparous women with a singleton pregnancy who received fentanyl i.v.-PCA (i.v.-PCA group, n = 290) or no analgesia (control group, n = 1111) in labor between 2005 and 2010 were reviewed. Fentanyl i.v.-PCA was implemented on maternal request during the first stage of labor over 35 weeks of gestation, and discontinued at full cervical dilatation. Perinatal outcomes were compared between the i.v.-PCA and the control groups. The numerical rating scale (NRS) levels during labor were also examined in the i.v.-PCA group. Additionally, parturients received fentanyl i.v.-PCA in 2010 (n = 73) were asked about overall satisfaction using a scale poor, moderate, good and excellent on postpartum day 0-3. Results: Women receiving i.v.-PCA showed significantly longer labor and more need of oxytocin augmentation, compared with the control. Cesarean section was significantly less frequent in the i.v.-PCA group compared with the control (11.0% v.s. 24.1%, respectively), with the vacuum-assisted delivery rate comparable between groups. Neonatal outcomes (i.e. Apgar score <7 at 1 min or 5 min, umbilical artery pH <7.20) were comparable between groups, irrespective of mode of delivery. Significant reduction of NRS levels was noted until 3 h after induction of i.v.-PCA, compared to the baseline. Of the women who expressed their satisfaction, 72% (48/67) exhibited 'excellent' or 'good' for pain relief by i.v.-PCA. Conclusion: Fentanyl i.v.-PCA could be a useful approach for labor pain relief in nulliparas when regional blocks are unavailable.

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