Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy

Daisuke Kajiura, Hisami Yamanaka-Okumura, Akiyoshi Hirayama, Hiroshi Tatano, Keiko Endo, Mayu Honma, Kaori Igarashi, Futaba Shoji, Satsuki Ikeda, Nozomi Yamaguchi, Takafumi Katayama, Yuji Morine, Satoru Imura, Tohru Utsunomiya, Tomoyoshi Soga, Masaru Tomita, Mitsuo Shimada

Research output: Contribution to journalArticle

Abstract

Objectives: Perioperative nutritional management is essential for early recovery after liver surgery. The aim of this study was to assess changes in amino acid levels in serum and urine after hepatectomy. Methods: Serum samples were collected from 16 patients with hepatocellular carcinoma before and 1, 3, and 14 d after hepatectomy (S0, S1, S3, and S14, respectively). Spot urine samples were collected before and 3 d after the hepatectomy (U0 and U3). Metabolites in the serum and urine were analyzed. Results: Compared with S0, insulin levels significantly increased in the S1 and S3 samples. Valine levels significantly decreased in S1 and S14, and leucine levels significantly decreased in S14. Phenylalanine levels significantly increased in S1 and S3, and tyrosine levels significantly increased in S1. The Fischer ratio (branched-chain/aromatic amino acids) significantly decreased in S1 and S3. In multiple regression analysis, changes in serum taurine levels were related to the white blood cell count in S1 and S3, and inversely related to alanine aminotransferase levels in S14. Changes in serum glutamine levels were negatively related to C-reactive protein levels in S3. Serum glutamine levels decreased in S3 and S14, and tended to increase in U3, suggesting a deficiency of glutamate resulting from the invasive surgical procedure. Conclusions: These findings highlight the usefulness of metabolome analysis for characterizing perioperative patterns after liver resection. The observed amino acid pattern, including the reduction in Fischer ratio, underscores the need for specialized nutritional support.

LanguageEnglish
Pages110-119
Number of pages10
JournalNutrition
Volume58
DOIs
Publication statusPublished - 2019 Feb 1

Fingerprint

Metabolome
Hepatectomy
Hepatocellular Carcinoma
Urine
Serum
Glutamine
Amino Acids
Branched Chain Amino Acids
Aromatic Amino Acids
Nutritional Support
Liver
Taurine
Valine
Alanine Transaminase
Phenylalanine
Leukocyte Count
Leucine
C-Reactive Protein
Tyrosine
Glutamic Acid

Keywords

  • 3-Methylhistidine
  • Branched-chain amino acids
  • Hepatectomy
  • Hepatocellular carcinoma
  • Metabolomics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Kajiura, D., Yamanaka-Okumura, H., Hirayama, A., Tatano, H., Endo, K., Honma, M., ... Shimada, M. (2019). Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy. Nutrition, 58, 110-119. https://doi.org/10.1016/j.nut.2018.06.002

Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy. / Kajiura, Daisuke; Yamanaka-Okumura, Hisami; Hirayama, Akiyoshi; Tatano, Hiroshi; Endo, Keiko; Honma, Mayu; Igarashi, Kaori; Shoji, Futaba; Ikeda, Satsuki; Yamaguchi, Nozomi; Katayama, Takafumi; Morine, Yuji; Imura, Satoru; Utsunomiya, Tohru; Soga, Tomoyoshi; Tomita, Masaru; Shimada, Mitsuo.

In: Nutrition, Vol. 58, 01.02.2019, p. 110-119.

Research output: Contribution to journalArticle

Kajiura, D, Yamanaka-Okumura, H, Hirayama, A, Tatano, H, Endo, K, Honma, M, Igarashi, K, Shoji, F, Ikeda, S, Yamaguchi, N, Katayama, T, Morine, Y, Imura, S, Utsunomiya, T, Soga, T, Tomita, M & Shimada, M 2019, 'Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy' Nutrition, vol. 58, pp. 110-119. https://doi.org/10.1016/j.nut.2018.06.002
Kajiura, Daisuke ; Yamanaka-Okumura, Hisami ; Hirayama, Akiyoshi ; Tatano, Hiroshi ; Endo, Keiko ; Honma, Mayu ; Igarashi, Kaori ; Shoji, Futaba ; Ikeda, Satsuki ; Yamaguchi, Nozomi ; Katayama, Takafumi ; Morine, Yuji ; Imura, Satoru ; Utsunomiya, Tohru ; Soga, Tomoyoshi ; Tomita, Masaru ; Shimada, Mitsuo. / Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy. In: Nutrition. 2019 ; Vol. 58. pp. 110-119.
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abstract = "Objectives: Perioperative nutritional management is essential for early recovery after liver surgery. The aim of this study was to assess changes in amino acid levels in serum and urine after hepatectomy. Methods: Serum samples were collected from 16 patients with hepatocellular carcinoma before and 1, 3, and 14 d after hepatectomy (S0, S1, S3, and S14, respectively). Spot urine samples were collected before and 3 d after the hepatectomy (U0 and U3). Metabolites in the serum and urine were analyzed. Results: Compared with S0, insulin levels significantly increased in the S1 and S3 samples. Valine levels significantly decreased in S1 and S14, and leucine levels significantly decreased in S14. Phenylalanine levels significantly increased in S1 and S3, and tyrosine levels significantly increased in S1. The Fischer ratio (branched-chain/aromatic amino acids) significantly decreased in S1 and S3. In multiple regression analysis, changes in serum taurine levels were related to the white blood cell count in S1 and S3, and inversely related to alanine aminotransferase levels in S14. Changes in serum glutamine levels were negatively related to C-reactive protein levels in S3. Serum glutamine levels decreased in S3 and S14, and tended to increase in U3, suggesting a deficiency of glutamate resulting from the invasive surgical procedure. Conclusions: These findings highlight the usefulness of metabolome analysis for characterizing perioperative patterns after liver resection. The observed amino acid pattern, including the reduction in Fischer ratio, underscores the need for specialized nutritional support.",
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AU - Kajiura, Daisuke

AU - Yamanaka-Okumura, Hisami

AU - Hirayama, Akiyoshi

AU - Tatano, Hiroshi

AU - Endo, Keiko

AU - Honma, Mayu

AU - Igarashi, Kaori

AU - Shoji, Futaba

AU - Ikeda, Satsuki

AU - Yamaguchi, Nozomi

AU - Katayama, Takafumi

AU - Morine, Yuji

AU - Imura, Satoru

AU - Utsunomiya, Tohru

AU - Soga, Tomoyoshi

AU - Tomita, Masaru

AU - Shimada, Mitsuo

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N2 - Objectives: Perioperative nutritional management is essential for early recovery after liver surgery. The aim of this study was to assess changes in amino acid levels in serum and urine after hepatectomy. Methods: Serum samples were collected from 16 patients with hepatocellular carcinoma before and 1, 3, and 14 d after hepatectomy (S0, S1, S3, and S14, respectively). Spot urine samples were collected before and 3 d after the hepatectomy (U0 and U3). Metabolites in the serum and urine were analyzed. Results: Compared with S0, insulin levels significantly increased in the S1 and S3 samples. Valine levels significantly decreased in S1 and S14, and leucine levels significantly decreased in S14. Phenylalanine levels significantly increased in S1 and S3, and tyrosine levels significantly increased in S1. The Fischer ratio (branched-chain/aromatic amino acids) significantly decreased in S1 and S3. In multiple regression analysis, changes in serum taurine levels were related to the white blood cell count in S1 and S3, and inversely related to alanine aminotransferase levels in S14. Changes in serum glutamine levels were negatively related to C-reactive protein levels in S3. Serum glutamine levels decreased in S3 and S14, and tended to increase in U3, suggesting a deficiency of glutamate resulting from the invasive surgical procedure. Conclusions: These findings highlight the usefulness of metabolome analysis for characterizing perioperative patterns after liver resection. The observed amino acid pattern, including the reduction in Fischer ratio, underscores the need for specialized nutritional support.

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