Abstract
Objectives: Perioperative nutritional management is essential for early recovery after liver surgery. The aim of this study was to assess changes in amino acid levels in serum and urine after hepatectomy. Methods: Serum samples were collected from 16 patients with hepatocellular carcinoma before and 1, 3, and 14 d after hepatectomy (S0, S1, S3, and S14, respectively). Spot urine samples were collected before and 3 d after the hepatectomy (U0 and U3). Metabolites in the serum and urine were analyzed. Results: Compared with S0, insulin levels significantly increased in the S1 and S3 samples. Valine levels significantly decreased in S1 and S14, and leucine levels significantly decreased in S14. Phenylalanine levels significantly increased in S1 and S3, and tyrosine levels significantly increased in S1. The Fischer ratio (branched-chain/aromatic amino acids) significantly decreased in S1 and S3. In multiple regression analysis, changes in serum taurine levels were related to the white blood cell count in S1 and S3, and inversely related to alanine aminotransferase levels in S14. Changes in serum glutamine levels were negatively related to C-reactive protein levels in S3. Serum glutamine levels decreased in S3 and S14, and tended to increase in U3, suggesting a deficiency of glutamate resulting from the invasive surgical procedure. Conclusions: These findings highlight the usefulness of metabolome analysis for characterizing perioperative patterns after liver resection. The observed amino acid pattern, including the reduction in Fischer ratio, underscores the need for specialized nutritional support.
| Original language | English |
|---|---|
| Pages (from-to) | 110-119 |
| Number of pages | 10 |
| Journal | Nutrition |
| Volume | 58 |
| DOIs | |
| Publication status | Published - 2019 Feb 1 |
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Keywords
- 3-Methylhistidine
- Branched-chain amino acids
- Hepatectomy
- Hepatocellular carcinoma
- Metabolomics
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy. / Kajiura, Daisuke; Yamanaka-Okumura, Hisami; Hirayama, Akiyoshi; Tatano, Hiroshi; Endo, Keiko; Honma, Mayu; Igarashi, Kaori; Shoji, Futaba; Ikeda, Satsuki; Yamaguchi, Nozomi; Katayama, Takafumi; Morine, Yuji; Imura, Satoru; Utsunomiya, Tohru; Soga, Tomoyoshi; Tomita, Masaru; Shimada, Mitsuo.
In: Nutrition, Vol. 58, 01.02.2019, p. 110-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy
AU - Kajiura, Daisuke
AU - Yamanaka-Okumura, Hisami
AU - Hirayama, Akiyoshi
AU - Tatano, Hiroshi
AU - Endo, Keiko
AU - Honma, Mayu
AU - Igarashi, Kaori
AU - Shoji, Futaba
AU - Ikeda, Satsuki
AU - Yamaguchi, Nozomi
AU - Katayama, Takafumi
AU - Morine, Yuji
AU - Imura, Satoru
AU - Utsunomiya, Tohru
AU - Soga, Tomoyoshi
AU - Tomita, Masaru
AU - Shimada, Mitsuo
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Objectives: Perioperative nutritional management is essential for early recovery after liver surgery. The aim of this study was to assess changes in amino acid levels in serum and urine after hepatectomy. Methods: Serum samples were collected from 16 patients with hepatocellular carcinoma before and 1, 3, and 14 d after hepatectomy (S0, S1, S3, and S14, respectively). Spot urine samples were collected before and 3 d after the hepatectomy (U0 and U3). Metabolites in the serum and urine were analyzed. Results: Compared with S0, insulin levels significantly increased in the S1 and S3 samples. Valine levels significantly decreased in S1 and S14, and leucine levels significantly decreased in S14. Phenylalanine levels significantly increased in S1 and S3, and tyrosine levels significantly increased in S1. The Fischer ratio (branched-chain/aromatic amino acids) significantly decreased in S1 and S3. In multiple regression analysis, changes in serum taurine levels were related to the white blood cell count in S1 and S3, and inversely related to alanine aminotransferase levels in S14. Changes in serum glutamine levels were negatively related to C-reactive protein levels in S3. Serum glutamine levels decreased in S3 and S14, and tended to increase in U3, suggesting a deficiency of glutamate resulting from the invasive surgical procedure. Conclusions: These findings highlight the usefulness of metabolome analysis for characterizing perioperative patterns after liver resection. The observed amino acid pattern, including the reduction in Fischer ratio, underscores the need for specialized nutritional support.
AB - Objectives: Perioperative nutritional management is essential for early recovery after liver surgery. The aim of this study was to assess changes in amino acid levels in serum and urine after hepatectomy. Methods: Serum samples were collected from 16 patients with hepatocellular carcinoma before and 1, 3, and 14 d after hepatectomy (S0, S1, S3, and S14, respectively). Spot urine samples were collected before and 3 d after the hepatectomy (U0 and U3). Metabolites in the serum and urine were analyzed. Results: Compared with S0, insulin levels significantly increased in the S1 and S3 samples. Valine levels significantly decreased in S1 and S14, and leucine levels significantly decreased in S14. Phenylalanine levels significantly increased in S1 and S3, and tyrosine levels significantly increased in S1. The Fischer ratio (branched-chain/aromatic amino acids) significantly decreased in S1 and S3. In multiple regression analysis, changes in serum taurine levels were related to the white blood cell count in S1 and S3, and inversely related to alanine aminotransferase levels in S14. Changes in serum glutamine levels were negatively related to C-reactive protein levels in S3. Serum glutamine levels decreased in S3 and S14, and tended to increase in U3, suggesting a deficiency of glutamate resulting from the invasive surgical procedure. Conclusions: These findings highlight the usefulness of metabolome analysis for characterizing perioperative patterns after liver resection. The observed amino acid pattern, including the reduction in Fischer ratio, underscores the need for specialized nutritional support.
KW - 3-Methylhistidine
KW - Branched-chain amino acids
KW - Hepatectomy
KW - Hepatocellular carcinoma
KW - Metabolomics
UR - http://www.scopus.com/inward/record.url?scp=85055910165&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055910165&partnerID=8YFLogxK
U2 - 10.1016/j.nut.2018.06.002
DO - 10.1016/j.nut.2018.06.002
M3 - Article
VL - 58
SP - 110
EP - 119
JO - Nutrition
JF - Nutrition
SN - 0899-9007
ER -