Perivascular nitric oxide gradients normalize tumor vasculature

Satoshi Kashiwagi, Kosuke Tsukada, Lei Xu, Junichi Miyazaki, Sergey V. Kozin, James A. Tyrrell, William C. Sessa, Leo E. Gerweck, Rakesh K. Jain, Dai Fukumura

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.

Original languageEnglish
Pages (from-to)255-257
Number of pages3
JournalNature Medicine
Volume14
Issue number3
DOIs
Publication statusPublished - 2008 Mar
Externally publishedYes

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Tumors
Nitric Oxide
Neoplasms
Nitric Oxide Synthase Type I
Oxygenation
Heterografts
Glioma
Cells
Radiation
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kashiwagi, S., Tsukada, K., Xu, L., Miyazaki, J., Kozin, S. V., Tyrrell, J. A., ... Fukumura, D. (2008). Perivascular nitric oxide gradients normalize tumor vasculature. Nature Medicine, 14(3), 255-257. https://doi.org/10.1038/nm1730

Perivascular nitric oxide gradients normalize tumor vasculature. / Kashiwagi, Satoshi; Tsukada, Kosuke; Xu, Lei; Miyazaki, Junichi; Kozin, Sergey V.; Tyrrell, James A.; Sessa, William C.; Gerweck, Leo E.; Jain, Rakesh K.; Fukumura, Dai.

In: Nature Medicine, Vol. 14, No. 3, 03.2008, p. 255-257.

Research output: Contribution to journalArticle

Kashiwagi, S, Tsukada, K, Xu, L, Miyazaki, J, Kozin, SV, Tyrrell, JA, Sessa, WC, Gerweck, LE, Jain, RK & Fukumura, D 2008, 'Perivascular nitric oxide gradients normalize tumor vasculature', Nature Medicine, vol. 14, no. 3, pp. 255-257. https://doi.org/10.1038/nm1730
Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA et al. Perivascular nitric oxide gradients normalize tumor vasculature. Nature Medicine. 2008 Mar;14(3):255-257. https://doi.org/10.1038/nm1730
Kashiwagi, Satoshi ; Tsukada, Kosuke ; Xu, Lei ; Miyazaki, Junichi ; Kozin, Sergey V. ; Tyrrell, James A. ; Sessa, William C. ; Gerweck, Leo E. ; Jain, Rakesh K. ; Fukumura, Dai. / Perivascular nitric oxide gradients normalize tumor vasculature. In: Nature Medicine. 2008 ; Vol. 14, No. 3. pp. 255-257.
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