Permanent restoration of human skin treated with cultured epithelium grafting--wound healing by stem cell based tissue engineering--.

Hideo Oshima, Hajime Inoue, Kyouichi Matsuzaki, Masayoshi Tanabe, Norio Kumagai

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

The technique of epidermal cell culture developed by Green and colleagues made a breakthrough in the treatment of massive wounds in vivo with grown cells in vitro. In the past two decades, progress of culture methods and clinical practice have been made and now it is possible to treat extensive skin defect with large amounts of cultured epithelium. Since 1985, we have been successfully used cultured epidermis as autografts for the permanent coverage of full-thickness burn wounds or excised burn scars, giant nevi, tattoos and so on. Furthermore, cultured epidermis has been available as allografts to promote the healing of chronic skin ulcers or deep dermal burn. In this paper we describe our clinical experience of cultured epithelium grafting for the treatment of wounds and predict new trial of wound management and regeneration based on tissue engineering concept.

Original languageEnglish
Pages (from-to)118-128
Number of pages11
JournalHuman cell : official journal of Human Cell Research Society
Volume15
Issue number3
DOIs
Publication statusPublished - 2002 Sep

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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