Permeability and blood compatibility of nanoporous parylene film-coated polyethersulfone membrane under long-term blood diffusion

Gunawan Setia Prihandana, Hikaru Ito, Ippei Sanada, Yuya Nishinaka, Yoshihiko Kanno, Norihisa Miki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nanoporous polyethersulfone (PES) membranes are widely used in dialysis systems due to their permeability and diffusion characteristics. However, PES membranes lack blood compatibility, which influences their permeability performance when employed in blood contact devices. Parylene film was deposited on a PES membrane surface and the membrane permeability and blood compatibility were investigated by long-term blood diffusion testing. After 28 days of testing, 90% of a bare PES membrane was covered with platelets, while the parylene film coated PES membrane had improved biocompatibility with a platelet coverage of only 20-30%. The permeability of the bare PES membrane significantly declined during the first 7 days of the blood diffusion and became stable after 8 days. In contrast, the permeability of the parylene film coated PES membrane exhibited more consistent performance during the entire test. Thus, parylene film coating on PES membrane has potential for application in hemodialysis systems. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2014, 131, 40024.

Original languageEnglish
Article number40024
JournalJournal of Applied Polymer Science
Volume131
Issue number6
DOIs
Publication statusPublished - 2014 Mar 15

Keywords

  • biocompatibility
  • biomedical applications
  • coatings
  • membranes

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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