Permeation control by thermosensitive shell layer of submicron microspheres

Takayuki Kato, Keiji Fujimoto, Haruma Kawaguchi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Monodisperse microspheres composed of ubiquinone (UQ)-containing hydrophobic core and thermosensitive hydrogel shell were prepared by soap-free emulsion copolymerization of hydrophobic monomers and N-isopropylacrylamide (NIPAM) in the presence of UQ. Some properties such as hydrodynamic size and electrophoretic mobility of the microspheres showed unique temperature-dependence. The rate of permeation of UQ-reducing and oxidizing agents from aqueous media to the microsphere core through the poly-NIPAM shell was measured as a function of temperature. The rate decreased gradually with increasing temperature and became near zero above the lower critical solution temperature of poly-NIPAM. Thus, a poly-NIPAM shell of microspheres can be regarded as thermo-sensitive ultra-thin membrane.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalPolymer Gels and Networks
Issue number3-4
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Pharmaceutical Science
  • Polymers and Plastics


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