Persistent parvovirus B19 infection resulting in red cell aplasia after allogeneic hematopoietic stem cell transplantation

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3 Citations (Scopus)

Abstract

Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.

Original languageEnglish
JournalTransplant Infectious Disease
Volume15
Issue number6
DOIs
Publication statusPublished - 2013 Dec

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Parvoviridae Infections
Parvovirus
Hematopoietic Stem Cell Transplantation
Transplantation
Viremia
Intravenous Immunoglobulins
Immunocompromised Host
Hematopoietic Stem Cells
Multiple Myeloma
Anemia
Transplants
DNA
Infection

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Multiple myeloma
  • Parvovirus B19
  • Persistent infection
  • Red cell aplasia

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

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title = "Persistent parvovirus B19 infection resulting in red cell aplasia after allogeneic hematopoietic stem cell transplantation",
abstract = "Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.",
keywords = "Allogeneic hematopoietic stem cell transplantation, Multiple myeloma, Parvovirus B19, Persistent infection, Red cell aplasia",
author = "Yuya Koda and Takehiko Mori and Jun Kato and S. Kohashi and Taku Kikuchi and Takayuki Mitsuhashi and Mitsuru Murata and T. Uemura and M. Handa and Shinichiro Okamoto",
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T1 - Persistent parvovirus B19 infection resulting in red cell aplasia after allogeneic hematopoietic stem cell transplantation

AU - Koda, Yuya

AU - Mori, Takehiko

AU - Kato, Jun

AU - Kohashi, S.

AU - Kikuchi, Taku

AU - Mitsuhashi, Takayuki

AU - Murata, Mitsuru

AU - Uemura, T.

AU - Handa, M.

AU - Okamoto, Shinichiro

PY - 2013/12

Y1 - 2013/12

N2 - Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.

AB - Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.

KW - Allogeneic hematopoietic stem cell transplantation

KW - Multiple myeloma

KW - Parvovirus B19

KW - Persistent infection

KW - Red cell aplasia

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