Abstract
Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.
| Original language | English |
|---|---|
| Journal | Transplant Infectious Disease |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2013 Dec |
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Keywords
- Allogeneic hematopoietic stem cell transplantation
- Multiple myeloma
- Parvovirus B19
- Persistent infection
- Red cell aplasia
ASJC Scopus subject areas
- Transplantation
- Infectious Diseases
Cite this
Persistent parvovirus B19 infection resulting in red cell aplasia after allogeneic hematopoietic stem cell transplantation. / Koda, Yuya; Mori, Takehiko; Kato, Jun; Kohashi, S.; Kikuchi, Taku; Mitsuhashi, Takayuki; Murata, Mitsuru; Uemura, T.; Handa, M.; Okamoto, Shinichiro.
In: Transplant Infectious Disease, Vol. 15, No. 6, 12.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Persistent parvovirus B19 infection resulting in red cell aplasia after allogeneic hematopoietic stem cell transplantation
AU - Koda, Yuya
AU - Mori, Takehiko
AU - Kato, Jun
AU - Kohashi, S.
AU - Kikuchi, Taku
AU - Mitsuhashi, Takayuki
AU - Murata, Mitsuru
AU - Uemura, T.
AU - Handa, M.
AU - Okamoto, Shinichiro
PY - 2013/12
Y1 - 2013/12
N2 - Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.
AB - Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.
KW - Allogeneic hematopoietic stem cell transplantation
KW - Multiple myeloma
KW - Parvovirus B19
KW - Persistent infection
KW - Red cell aplasia
UR - http://www.scopus.com/inward/record.url?scp=84888858811&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888858811&partnerID=8YFLogxK
U2 - 10.1111/tid.12155
DO - 10.1111/tid.12155
M3 - Article
C2 - 24134728
AN - SCOPUS:84888858811
VL - 15
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
SN - 1398-2273
IS - 6
ER -