Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable

Takanori Kanai, Yasuhiro Nemoto, Takayuki Tomita, Teruji Totsuka, Mamoru Watanabe, Toshifumi Hibi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Despite the advent of an age when "malignant" leukemia is cured by bone marrow transplantation, "benign" inflammatory bowel diseases (IBDs) are still intractable life-long diseases. Why is it that once an IBD develops it lasts a long time? We propose that, the same as in the response to vaccination, immune memory T cells that remember the disease are formed in IBDs and, perceiving them as "benign T-cell leukemia"-like lifelong pathology that hematogenously spreads throughout the body, we here propose that the bone marrow itself, which produces large amounts of the survival factor IL-7, is the reservoir for colitogenic CD4+ memory T cells responsible for the intractability of IBDs.

Original languageEnglish
Pages (from-to)926-934
Number of pages9
JournalInflammatory Bowel Diseases
Volume15
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Inflammatory Bowel Diseases
T-Lymphocytes
T-Cell Leukemia
Interleukin-7
Bone Marrow Transplantation
Leukemia
Vaccination
Bone Marrow
Pathology

Keywords

  • Colitogenic memory CD4 T
  • IL-7
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable. / Kanai, Takanori; Nemoto, Yasuhiro; Tomita, Takayuki; Totsuka, Teruji; Watanabe, Mamoru; Hibi, Toshifumi.

In: Inflammatory Bowel Diseases, Vol. 15, No. 6, 2009, p. 926-934.

Research output: Contribution to journalArticle

Kanai, Takanori ; Nemoto, Yasuhiro ; Tomita, Takayuki ; Totsuka, Teruji ; Watanabe, Mamoru ; Hibi, Toshifumi. / Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable. In: Inflammatory Bowel Diseases. 2009 ; Vol. 15, No. 6. pp. 926-934.
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