Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable

Takanori Kanai, Yasuhiro Nemoto, Takayuki Tomita, Teruji Totsuka, Mamoru Watanabe, Toshifumi Hibi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Despite the advent of an age when "malignant" leukemia is cured by bone marrow transplantation, "benign" inflammatory bowel diseases (IBDs) are still intractable life-long diseases. Why is it that once an IBD develops it lasts a long time? We propose that, the same as in the response to vaccination, immune memory T cells that remember the disease are formed in IBDs and, perceiving them as "benign T-cell leukemia"-like lifelong pathology that hematogenously spreads throughout the body, we here propose that the bone marrow itself, which produces large amounts of the survival factor IL-7, is the reservoir for colitogenic CD4+ memory T cells responsible for the intractability of IBDs.

Original languageEnglish
Pages (from-to)926-934
Number of pages9
JournalInflammatory bowel diseases
Volume15
Issue number6
DOIs
Publication statusPublished - 2009 Jul 16

Keywords

  • Colitogenic memory CD4 T
  • IL-7
  • Inflammatory bowel disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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