Personalized cancer immunotherapy: Immune biomarkers and combination immunotherapy

Yutaka Kawakami, Boryana Popivanova, Sunthamala Nuchsupha, Taeko Hayakawa, Kenta Nakamura, Haruna Nagumo, Ikumi Katano, Tomonari Kinoshita, Kinya Tsubota, Hajime Kamijuku, Naoshi Kawamura, Junichiro Miyazaki, Ryosuke Satomi, Juri Sugiyama, Hiroshi Nishio, Shinobu Noji, Chie Kudo-Saito, Nobuo Tsukamoto, Toshiharu Sakurai, Tomonobu FujitaTomonori Yaguchi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer immunotherapies utilizing tumor-specific T-cell responses, immune-checkpoint blockade, and T-cell-based adoptive cell therapy, have recently shown durable responses in advanced patients with various cancers. However, there are still cancer types and patients who do not respond to these immunotherapies. Pretreatment immune status varies in cancer patients, and it correlates with prognosis after various cancer therapies including immunotherapy. The differential T-cell response is defined by positive (e.g., number of immunogenic mutated peptides derived from mainly passenger DNA mutations in cancer cells, polymorphisms of immune-related genes of patients) and negative (e.g., oncogene activation including driver DNA mutations) immune pathways along with environmental factors (e.g., intestinal microbiota, diet, smoking, infection history). These factors could be biomarkers for selection of the patients who are likely to respond to immunotherapy and furthermore could be therapeutic targets to improve efficacy of immunotherapy possibly by combination immunotherapy with interventions on multiple key regulation points in the antitumor T-cell responses. Personalized combination immunotherapy based on the evaluation of T-cell immune status is a promising strategy for cancer treatment.

Original languageEnglish
Title of host publicationImmunotherapy of Cancer
Subtitle of host publicationAn Innovative Treatment Comes of Age
PublisherSpringer Japan
Pages349-358
Number of pages10
ISBN (Electronic)9784431550310
ISBN (Print)9784431550303
DOIs
Publication statusPublished - 2016 Feb 22

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Keywords

  • Biomarkers
  • Cancer immunopathology
  • Cancer immunotherapy
  • Combination therapy
  • Personalized therapy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kawakami, Y., Popivanova, B., Nuchsupha, S., Hayakawa, T., Nakamura, K., Nagumo, H., Katano, I., Kinoshita, T., Tsubota, K., Kamijuku, H., Kawamura, N., Miyazaki, J., Satomi, R., Sugiyama, J., Nishio, H., Noji, S., Kudo-Saito, C., Tsukamoto, N., Sakurai, T., ... Yaguchi, T. (2016). Personalized cancer immunotherapy: Immune biomarkers and combination immunotherapy. In Immunotherapy of Cancer: An Innovative Treatment Comes of Age (pp. 349-358). Springer Japan. https://doi.org/10.1007/978-4-431-55031-0_24