Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction

Masako Murai, Hiroyuki Yoneyama, Taichi Ezaki, Makoto Suematsu, Yuya Terashima, Akihisa Harada, Hiromasa Hamada, Hitoshi Asakura, Hiromichi Ishikawa, Kouji Matsushima

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

Acute graft-versus-host disease (a-GVHD) is initiated primarily by immunologically competent cytotoxic T cells (CTLs) that express anti-host specificities. However, the host lymphoid compartment in which these precursor CTLs are initially stimulated remains unclear. Here we show that gut Peyer's patches (PPs) are required to activate anti-host CTL responses in a well characterized murine acute graft-versus-host reaction (a-GVHR) model, involving transfer of parent lymphocytes into FI hybrid recipients. The a-GVHR was prevented when recruitment of donor T cells into PP was interrupted either by disrupting the gene encoding chemokine receptor CCR5 or by blocking integrin α4β7-MAdCAM-1 (mucosal vascular addressin) interactions. Mice deficient for PPs failed to develop a-GVHD in two models of disease induction. Thus, blockade of CTL generation in PPs might offer new strategies for circumventing a-GVHD.

Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalNature Immunology
Volume4
Issue number2
DOIs
Publication statusPublished - 2003 Feb 1

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Peyer's Patches
Graft vs Host Disease
T-Lymphocytes
Transplants
T-Lymphoid Precursor Cells
Chemokine Receptors
Host Specificity
Integrins
Lymphocytes
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Murai, M., Yoneyama, H., Ezaki, T., Suematsu, M., Terashima, Y., Harada, A., ... Matsushima, K. (2003). Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nature Immunology, 4(2), 154-160. https://doi.org/10.1038/ni879

Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. / Murai, Masako; Yoneyama, Hiroyuki; Ezaki, Taichi; Suematsu, Makoto; Terashima, Yuya; Harada, Akihisa; Hamada, Hiromasa; Asakura, Hitoshi; Ishikawa, Hiromichi; Matsushima, Kouji.

In: Nature Immunology, Vol. 4, No. 2, 01.02.2003, p. 154-160.

Research output: Contribution to journalArticle

Murai, M, Yoneyama, H, Ezaki, T, Suematsu, M, Terashima, Y, Harada, A, Hamada, H, Asakura, H, Ishikawa, H & Matsushima, K 2003, 'Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction', Nature Immunology, vol. 4, no. 2, pp. 154-160. https://doi.org/10.1038/ni879
Murai M, Yoneyama H, Ezaki T, Suematsu M, Terashima Y, Harada A et al. Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nature Immunology. 2003 Feb 1;4(2):154-160. https://doi.org/10.1038/ni879
Murai, Masako ; Yoneyama, Hiroyuki ; Ezaki, Taichi ; Suematsu, Makoto ; Terashima, Yuya ; Harada, Akihisa ; Hamada, Hiromasa ; Asakura, Hitoshi ; Ishikawa, Hiromichi ; Matsushima, Kouji. / Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. In: Nature Immunology. 2003 ; Vol. 4, No. 2. pp. 154-160.
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